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LCGC Europe-06-01-2019
LCGC Europe
The Evolution of 3D Printing
June 01, 2019
HPLC 2019: Hot Topics
32
6
This is the fifth in a series of articles exploring current topics in separation science that will be addressed at the HPLC 2019 conference in Milan, Italy, from 16–20 June.
Understanding How Dwell Volume Can Affect Selectivity in Reversed-Phase Gradient Chromatography
June 01, 2019
Cover Story
32
6
The effect of dwell volume on chromatographic selectivity can be successfully modelled using retention prediction software. Hence, the robustness of reversed-phase LC gradient methodologies, with respect to dwell volume, can be conveniently assessed.
Mixing and Mixers in Liquid Chromatography, Part 3: Solutions for Problems with Sample Diluents
June 01, 2019
LC Troubleshooting
32
6
Adding an inline mixer between the sample injector and column in a liquid chromatography (LC) system can be an effective way to resolve problems with peak shape caused by the sample diluent.
Denaturing and Native Size-Exclusion Chromatography Coupled to High-Resolution Mass Spectrometry for Detailed Characterization of Monoclonal Antibodies and Antibody–Drug Conjugates
June 01, 2019
Biopharmaceutical Perspectives
32
6
Monoclonal antibodies (mAbs) are being developed at an explosive rate and have attracted great interest from both smaller biotech firms and big pharmaceutical companies. Developing mAbs and next-generation antibody–drug conjugates (ADCs) is highly demanding in many ways. From an analytical perspective, handling mAbs and ADCs presents many new challenges. This article describes how size-exclusion chromatography (SEC) combined with high-resolution mass spectrometry (HRMS) can be applied to the detailed characterization of mAbs and ADCs.
Towards Merging Targeted and Untargeted Analysis of the Lipidome, Metabolome, and Exposome
June 01, 2019
HPLC 2019: Hot Topics
32
6
Tomas Cajka previews his keynote lecture at HPLC 2019, where he will introduce an LC−MS workflow (LIpids, Metabolites and eXposome compounds [LIMeX]) for simultaneous extraction of complex lipids, polar metabolites, and exposome compounds that combines LC–MS targeted and untargeted analysis.
Multidimensional Liquid Chromatography Approaches for Characterization of Protein Biopharmaceuticals
June 01, 2019
HPLC 2019: Hot Topics
32
6
Davy Guillarme previews his presentation at HPLC 2019 highlighting the new trends in LC×LC applied for biopharmaceutical characterization, including the hyphenation with high‑resolution mass spectrometry (HRMS) and ion mobility spectrometry (IMS).
Capillary Electrophoresis–Mass Spectrometry for Metabolomics: Extracting Chemical Information from Less
June 01, 2019
HPLC 2019: Hot Topics
32
6
Rawi Ramautar discusses capillary electrophoresis–mass spectrometry for metabolomics and previews the topic for HPLC 2019.
Making Nontargeted Liquid Chromatography–High-Resolution Mass Spectrometry Analysis Quantitative
June 01, 2019
HPLC 2019: Hot Topics
32
6
Anneli Kruve previews the topic of nontargeted liquid chromatography–high-resolution Mass spectrometry for HPLC 2019.
Perspectives in Clinical and Pharmaceutical Solid-Phase Microextraction
June 01, 2019
HPLC 2019: Hot Topics
32
6
Barbara Bojko previews the topic of solid-phase micoextraction for clinical and pharmaceutical research.
The Benefits of a Liquid-Electron Ionization Liquid Chromatography–Mass Spectrometry Interface
June 01, 2019
HPLC 2019: Hot Topics
32
6
Achille Cappiello previews the topic and the benefits of liquid-electron ionization liquid chromatography–mass spectrometry interfaces for HPLC 2019.
The 11th Encontro Nacional de Cromatografia (11ENC)
June 01, 2019
Events
32
6
The 11th Encontro Nacional de Cromatografia (11ENC) will be held 9–11 December 2019 at Hotel Aldeia dos Capuchos, Congress Centre, in Caparica, Portugal.
Solving Recovery Problems in SPE
June 01, 2019
The Essentials
32
6
A guide to solving recovery problems in solid-phase extraction (SPE)
Vol 32 No 06 LCGC Europe June 2019 Regular Issue PDF
June 01, 2019
Issue PDF
32
6
Click the title above to open the LCGC Europe June 2019 regular issue, Vol 32, No 06, in an interactive PDF format.
Hot Topics Preview: A Universal Generic (U)HPLC Reversed-Phase Gradient Method for Quality Assessments of Multiple Small Molecule Drugs
May 01, 2019
HPLC 2019: Hot Topics
32
6
Wouldn’t it be nice if a single generic high performance liquid chromatography (HPLC) method could be used for all small molecule drugs - not only for potency assays but also for ICH-compliant stability-indicating assays?