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Paper spray mass spectrometry (MS) allows for the direct analysis of pharmaceuticals, drugs of abuse, and other small molecules from blood, urine, and other biofluids (1,2).

Chromatography data systems (CDSs) have had a starring role in many regulatory citations involving falsification and fraud in analytical laboratories regulated by Good Manufacturing Practices (GMP). In this instalment of "Questions of Quality" we will examine the citations and identify the technical and procedural controls required to ensure data integrity within these systems. Although focused primarily on the pharmaceutical industry, the principles described here are applicable to all laboratories working to established quality standards.

This year's HPLC symposium was held in New Orleans, Louisiana, USA. In this review, Ron Majors covers HPLC and UHPLC column and sample preparation highlights, summarizes the awards presented, and reviews the overall liquid-phase chromatography trends.

How can resolution be determined when peak width cannot be measured?

A review of the essential elements of MS approaches to protein quantification and a critical comparison of the available options

The numerous advantages of translating gradient chromatographic methods between the differing formats of liquid chromatography (LC) have been explored and discussed.

Many problems encountered executing HPLC methods are a result of decisions made during early method development. This article discusses one critical variable in method development, the choice of stationary phase chemistry.

An investigation into some "typical" HPLC method specifications to highlight ways of critically evaluating the major and minor parameters of a method

An efficient method for forensic analysis of amphetamines and synthetic cathinones - the illicit drugs often called "bath salts" - in hair samples.

A look at what's in store for chromatographers at the Analytica China Conference. The conference and the exhibition will take place at the Shanghai New International Expo Center, Shanghai, People's Republic of China, from 24–26 September 2014.

Since the gas flow required for the separation step in gas chromatography is frequently lower than that required to optimize the detection, nitrogen is used as a make-up gas to increase the gas flow for detection.

Click the title above to open the LCGC Asia Pacific September 2014 regular issue, Vol 17, No 3, in an interactive PDF format.

Click the title above to open the LCGC Europe September 2014 regular issue, Vol 27, No 9, in an interactive PDF format.

Click the title above to open the LCGC North America September 2014 regular issue, Vol 32 No 9, in an interactive PDF format.

Click the title above to open the LCGC North America September 2014 Application Notebook, Vol 32 No s9, in an interactive PDF format.

This article reviews recent developments that aim to address the conflicting demands for higher throughput, sensitivity, and selectivity in bioanalysis applications.

Incognito attends a sushi class and ponders the plight of the analytical scientist.

A new study published in the Journal of Agricultural and Food Chemistry highlights the potential use of rosemary and oregano in the management of Type 2 diabetes mellitus (T2DM).

When a scientist needs to search through scientific literature, which is the preferred search engine? While there is quite a bit of variety in available search engines, LCGC Blogger Kevin Schug has a definite preference. Here's what it is, and why.

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