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Better detection, separation, and ionization of cannabinoids by a high pH LC/MS method method that utilizes a high performance Kinetex EVO C18 column.

Quantitative method to accurately monitor paraben levels in food and other personal care products using Novum Simplified Liquid Extraction (SLE) products in conjunction with a Kinetex EVO C18 5 μm core-shell HPLC column.

Better detection, separation, and ionization of cannabinoids by a high pH LC/MS method method that utilizes a high performance Kinetex EVO C18 column.

Quantitative method to accurately monitor paraben levels in food and other personal care products using Novum Simplified Liquid Extraction (SLE) products in conjunction with a Kinetex EVO C18 5 μm core-shell HPLC column.

Mass spectrometry (MS) is considered to be the gold standard in chemical detection due to the speed, selectivity, sensitivity, and versatility of the method. A miniaturized, linear ion trap, mass spectrometer can rapidly detect and unequivocally identify chemical targets that reduce the cost to analyze field samples and, more importantly, eliminate gaps in security because actionable information can be obtained on timescales that are relevant for security personnel

Ultra high resolution, accurate mass (UHRAM) mass spectrometry, based on the Thermo ScientificTM OrbitrapTM technology, is a powerful new approach to high throughput screening and quantitation in complex sample matrices. To learn more about how UHRAM is used in the Million Metabolome Project, an ambitious milestone for Exposome Research, LCGC talked with Dean Jones of Emory University.Click to view the associated whitepaper

A method is illustrated for the simultaneous analysis of nicotine, anabasine, and three of nicotine’s major metabolites (cotinine, nornicotine, and 3-hydroxycotinine) using the Kinetex 2.6 μm EVO C18 column.

Better identification and quantitation of low level peptides utilizing the powerful combination of unique selectivity and core-shell performance gains found with Kinetex EVO C18 core-shell columns.

Better identification and quantitation of low level peptides utilizing the powerful combination of unique selectivity and core-shell performance gains found with Kinetex EVO C18 core-shell columns.

Achieve excellent peak shape and resolution between the broad spectrum antibiotic cefaclor and its degredants using the unique selectivity and high efficiency of a Kinetex EVO C18 core-shell.

Achieve excellent peak shape and resolution between the broad spectrum antibiotic cefaclor and its degredants using the unique selectivity and high efficiency of a Kinetex EVO C18 core-shell.

Rapid and comprehensive resolution of a cold medicine API screen that can easily be implemented on HPLC and UHPLC instrumentation using a high performance core-shell Kinetex 2.6 μm EVO C18 column

Rapid and comprehensive resolution of a cold medicine API screen that can easily be implemented on HPLC and UHPLC instrumentation using a high performance core-shell Kinetex 2.6 μm EVO C18 column

A high performance, pH stable core-shell Kinetex EVO C18 column obtains narrow peak shape and extremely useful resolution for a doxylamine formulation impurity profile.

Highly sensitive and reliable screen of Benzodiazepines, Opiates, Synthetic Opioids, Amphetamines, Analgesics and Illicit Drugs

A high performance, pH stable core-shell Kinetex EVO C18 column obtains narrow peak shape and extremely useful resolution for a doxylamine formulation impurity profile.

Enjoy the unique Kinetex EVO C18 selectivity now in 1.7µm and 2.6µm particle sizes for your UHPLC work. This extremely versatile core-shell phase offers the high performance you crave, a unique all-purpose selectivity, and ruggedness you can depend on.

Enjoy the unique Kinetex EVO C18 selectivity now in 1.7µm and 2.6µm particle sizes for your UHPLC work. This extremely versatile core-shell phase offers the high performance you crave, a unique all-purpose selectivity, and ruggedness you can depend on.

Highly sensitive and reliable screen of Benzodiazepines, Opiates, Synthetic Opioids, Amphetamines, Analgesics and Illicit Drugs

Click the title above to open The Column June 05, 2015 Europe & Asia issue, Volume 11, Number 10, in an interactive PDF format.

Click the title above to open The Column June 05, 2015 North American issue, Volume 11, Number 10, in an interactive PDF format.

Click the title above to open the LCGC Europe June 2015 Recent Developments in HPLC and UHPLC Supplement, Vol 28, No s6, in an interactive PDF format.

Environmental sample analysis by large-volume injection (LVI) in combination with liquid chromatography–tandem mass spectrometry (LC–MS-MS) is described for polar and nonpolar analytes in both aqueous samples and organic extracts.

Unexpected results from calibration standards create confusion in a clinical liquid chromatography (LC) method.

Readers’ questions regarding problems related to internal standard calibration of liquid chromatography methods are addressed.

This instalment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery. It describes the use of reversed-phase liquid chromatography (LC) and supercritical fluid chromatography (SFC) for purifying diverse samples in a centralized laboratory setting. A case study is used to illustrate the principles and rationales for selecting operating parameters for these applications. This is the first instalment of four articles on “Separation Science in Drug Development” to describe the modern practice of separation science in supporting small-molecule drug discovery and development.