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Click the title above to open the LCGC Europe 2014 regular issue, Vol 27 No , in an interactive PDF format.

Click the title above to open the LCGC North America January 2014 regular issue, Vol 32 No 1, in an interactive PDF format.

The head of the Chinese Academy of Sciences Interdisciplinary Research Center on Biology and Chemistry (Beijing, China), Junying Yuan, has received an Agilent Thought Leader Award. Agilent Technologies (California, USA) has given the award in recognition of Yuan?s scientific contributions to cellular biology and the understanding of neurodegenerative diseases.

Waters Corporation (Massachusetts, USA) has announced that Chief Financial Officer John Ornell intends to move to a reduced workload and resign from 1 February 2014. Ornell will continue to work for the company in an advisory capacity on a part-time basis. Eugene G. Cassis, currently Corporate Vice President of Worldwide Business Development and Investor Relations, will serve as the company?s interim Chief Financial Officer from 1 February 2014.

The head of the Chinese Academy of Sciences Interdisciplinary Research Center on Biology and Chemistry (Beijing, China), Junying Yuan, has received an Agilent Thought Leader Award. Agilent Technologies (California, USA) has given the award in recognition of Yuan?s scientific contributions to cellular biology and the understanding of neurodegenerative diseases.

There has been much focus within the industry of late on ways of improving the way in which HPLC method development is carried out - which has led to a more widespread adoption of modelling and optimisation software combined with dedicated method development platforms from the major instrument vendors.

Waters Corporation (Massachusetts, USA) has announced that Chief Financial Officer John Ornell intends to move to a reduced workload and resign from 1 February 2014. Ornell will continue to work for the company in an advisory capacity on a part-time basis. Eugene G. Cassis, currently Corporate Vice President of Worldwide Business Development and Investor Relations, will serve as the company?s interim Chief Financial Officer from 1 February 2014.

Click here to view the full European E-newsletter from December 19.

Click here to view the full European E-newsletter from December 19.

Proteins, monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are powerful therapeutic agents. Because of their high molecular complexity, however, biopharmaceuticals may be quite sensitive to changes in the manufacturing processes that can lead to considerable micro-heterogeneity. As a result, a panel of separation techniques based on both liquid chromatography and electrophoresis has been used for their characterization and comparability studies. In terms of detection, mass spectrometry (MS) plays a pivotal role in the structural elucidation of biopharmaceuticals, because it offers an additional degree of separation by mass/charge ratio, greatly facilitating the characterization of variants. This two-part web seminar will discuss possibilities and limitations of chromatographic techniques and mass spectrometry detection for the physico-chemical characterization of biopharmaceutical compounds. Part II will focus on mass spectrometry techniques for the physico-chemical characterization of mAbs and related compounds. Classical MS analysis comprising intact mAb mass measurements, LC-MS analyses in reducing conditions or after deglycosylation treatment, and peptide mapping will be presented. The focus will be on enzymatic treatments that generate mAb fragments of smaller size that are more readily analyzable by MS techniques. In this presentation, some new trends in MS including native MS and ion mobility?MS (IM-MS) approaches will be also discussed. Finally, the benefits of high resolution native MS analysis will be explained.

Proteins, monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are powerful therapeutic agents. Because of their high molecular complexity, however, biopharmaceuticals may be quite sensitive to changes in the manufacturing processes that can lead to considerable micro-heterogeneity. As a result, a panel of separation techniques based on both liquid chromatography and electrophoresis has been used for their characterization and comparability studies. In terms of detection, mass spectrometry (MS) plays a pivotal role in the structural elucidation of biopharmaceuticals, because it offers an additional degree of separation by mass/charge ratio, greatly facilitating the characterization of variants. This two-part web seminar will discuss possibilities and limitations of chromatographic techniques and mass spectrometry detection for the physico-chemical characterization of biopharmaceutical compounds. Part I will focus on chromatographic techniques used for the physico-chemical characterization of biopharmaceutical compounds. Historically, ion exchange chromatography (IEX) and size exclusion chromatography (SEC) were the reference techniques. In this presentation, some new trends in IEX and SEC will be explained. However, because reversed-phase liquid chromatography is naturally more compatible with MS, the talk will focus on the potential of state-of-the-art UHPLC instruments and reversed-phase LC columns (sub-2?m wide-pore porous particles or core-shell particles) for biopharmaceutical characterization.

Click here to view the complete E-Separation Solutions newsletter from December 17, 2013.

Editors Series' : Integrating On-Line Sample Preparation and HPLC Separations with Triple Quadrupole Mass Spectrometry for Ultratrace Quantitative Analysis of Small Molecules from Complex Matrices

LCGC Pittcon 2014 product Review-Product2

Residues of chili pepper (Capsicum) have been found on pottery dating back 2000 years in southern Mexico, according to a study published in PLOS ONE.1 The New World Archeological Foundation (NWAF) first excavated the pottery (thought to date from 400 BCE–300 CE) from Chiapa de Corzo between 1955 and 1963.

Click here to view the complete E-Separation Solutions newsletter from December 12, 2013.

Flow injection analysis (FIA) is a powerful technique for quantitative analysis, especially in conjunction with mass spectrometry (MS) detection. Kevin Schug discusses how FIA can be combined with MS using electrospray ionization and describes how the technique can be used for analytes such as binding constant determination, multipoint instrument response calibrations, and removing the dependence of measured analyze concentrations on matrix effects.

Fully automated Dried Blood Spot (DBS) Extraction System for MS. On-card IS application module for extraction efficiencies and matrix effect correction. Wash station for minimized carry-over effects.

Residues of chili pepper (Capsicum) have been found on pottery dating back 2000 years in southern Mexico, according to a study published in PLOS ONE.1 The New World Archeological Foundation (NWAF) first excavated the pottery (thought to date from 400 BCE?300 CE) from Chiapa de Corzo between 1955 and 1963.

Biotage (Uppsala, Sweden) has opened a new manufacturing unit in Ystrad Mynach, South Wales, with the support of the Welsh Government. As part of the expansion at the South Wales site, an instrument-manufacturing unit has been moved from Boston, USA. Thanks to a grant from the Welsh Government, the company secured the use of a 825 square metre facility near to their existing premises and converted the area into a manufacturing line and offices.

Click here to view the full European E-newsletter from December 12.

A selective review of companies who launched products in 2013.

The variance in the toxic effects of designer cannabis drugs marketed throughout Europe and the USA as "K2" or "Spice" could be the result of stereoselective metabolism of enantiomers by lung and liver enzymes, according to a study published in Analytical Chemistry.

Scientists at Sandia National Laboratories are thinking smaller in the development of detectors for military use - from the detection of explosives and chemical weapons to humans. Scientist Ron Manginell from the laboratories spoke to The Column about the on-going research in this area.

The ancient Egyptians embalmed meat mummies as an afterlife snack in the same way as their dead, according to the findings of a gas chromatography–mass spectrometry (GC–MS) analysis.

This article describes the analysis of fluorescently labelled N-glycans released from proteins by liquid chromatography–mass spectrometry (LC–MS).

Shoulders in gel permeation/size-exclusion chromatograms (GPC/SEC) can be a result of sample characteristics or down to the wrong choice of columns or column combinations. Proper selection helps to measure true results.