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Using a fixed length-variant of the kinetic plot method, it is illustrated how an analysis that is performed near the optimal flow-rate of a given commercial column can, in many cases, be performed between 50–200% faster by switching to a longer column and operating it at a higher pressure - at least, if the available instrument pressure admits so. The present article aims to show that short columns are not always the best choice to get the fastest separation.

Various modes of capillary electrochromatography (CEC) for the separation of enantiomers on immobilized cyclodextrin derivatives are described. The following techniques have been used: (i) open-tubular electrochromatography (o-CEC), (ii) packed electrochromatography (p-CEC) and (iii) monolithic electrochromatography (rod-CEC). Three different strategies to prepare enantioselective cyclodextrin-coated chiral monoliths are described. The advantages and disadvantages of the various methods are outlined.

Markes International has enhanced its online shop, increasing the number of products offered to include the majority of the thermal desorption (TD) instrument spares, accessories and consumables found in its new catalogue.

Hichrom will be sponsoring a series of HPLC workshops led by world-renowned HPLC trainers including John Dolan, Mel Euerby and Tom Jupille. The workshops are running throughout 2009 at sites across the UK including Reading, Manchester and London.

Markes International has enhanced its online shop, increasing the number of products offered to include the majority of the thermal desorption (TD) instrument spares, accessories and consumables found in its new catalogue.

Hichrom will be sponsoring a series of HPLC workshops led by world-renowned HPLC trainers including John Dolan, Mel Euerby and Tom Jupille. The workshops are running throughout 2009 at sites across the UK including Reading, Manchester and London.

Waters reported fourth quarter 2008 sales of $418 million, a decrease of 4% from sales of $437 million in the fourth quarter of 2007. In the quarter, the effects of foreign currency translation were responsible for the reduced sales growth rate.

Proxeon has announced that it will join 12 other partners in a research consortium, PROSPECTS (PROteomics SPECification in Time and Space). The collaborators come from leading proteomics laboratories and companies.

A rapid and sensitive method for the determination of ropinirole in human plasma has been developed. The method achieves a S/N of over 100:1 at the required LLOQ of 0.005 ng/mL.

Joining us for this discussion are Troy Purvis and Chad Ostrander of Hitachi High Technologies America; Thomas J. Waeghe of MAC-MOD Analytical; Dr. Roy Eksteen of Tosoh Bioscience, LLC.; and Thomas E. Beesley of Sigma-Aldrich/Supelco.

The 23rd International Forum for Process Analytical Technology (IFPAC-09) will be held at the Baltimore Marriott Waterfront Hotel, located within Baltimore's Inner Harbor, from January 25 through January 28, 2009.

The fourth European Award for Plasma Spectrochemistry is to be awarded to Dr Annemie Bogaerts, professor of physical chemistry at the University of Antwerp, Belgium.

Varian, Inc. has published an application note entitled Enhanced ELSD Sensitivity of Parabens using Sub-Ambient Evaporation. Parabens are widely used as food additives, in personal care products and pharmaceutical formulations. They are relatively volatile but can easily be detected by the Varian ELSD. By manipulating the operating conditions, the Varian ELSD detects semi-volatile parabens, thus conserving sample integrity and providing maximum sensitivity. This application note shows that the innovative design of the Varian ELSD represents the next generation of ELSD technology, providing optimum performance across a diverse range of HPLC applications.

Dionex has entered into an agreement with Caliper Life Sciences to purchase Caliper's AutoTrace line of products...

Top news items in the chromatography field.

Additional upcoming events in the chromatography field.

Incorporating metabolite profiling for absorption, distribution, metabolism, and excretion (ADME) properties early in the drug discovery process has resulted in an increase in drug success in development by reducing failure rates due to poor pharmacokinetic properties (1).

Upcoming educational events in the chromatography field.

Additional education events in the chromatography field.

Italian researchers in Rome (Universita Cattolica and Consiglio Nazionale delle Ricerche) and Cagliari (Universita di Cagliari) have used reversed-phase high performance liquid chromatography with electrospray ionization mass spectrometry to analyze naturally occurring salivary peptides from subjects with autism and compare the profiles with those obtained from age-matched control subjects.

Researchers from Sun Yat-sen University and South China Normal University (both in Guangzhou, China) developed a sample preparation method for extracting the beta-blockers propranolol, atenolol, pindolol, and alprenolol from human plasma and urine samples.

David Ericson and Michal Lipson of Cornell University (Ithaca, New York) have a designed an optofluidic system that uses the pressure of light to move and manipulate biological molecules.

Bruker Corp (Billerica, Massachusetts) has developed a homeland security division, Bruker Detection, and a benchtop instrument for the detection of traces of explosives or drugs.

Researchers from Stockholm University (Stockholm, Sweden) and Nankai University (Tianjin, China) used a serial mixed-mode cation-exchange and anion-exchange solid-phase extraction (SPE) method to extract 15 basic, neutral, and acidic pharmaceutical compounds from wastewater.

The Pittsburgh Conference (Pittsburgh, Pennsylvania) announced that the topic of its 20th annual James L. Waters symposium will be near-infrared spectroscopy.

A research group from the University of Tehran (Tehran, Iran) used dispersive liquid?liquid microextraction coupled with gas chromatography to determine compounds in rose water, which is the hydrosol portion of the distillate of rose petals.