All News

Chiral Technologies Europe (Illkirch Cedex, France), a wholly owned subsidiary of DAICEL Chemical Industries, announced the acquisition of ChromTech Ltd. (Congleton, UK).

Scientists from the Swedish University of Agricultural Sciences (Uppsala, Sweden) and the University of Tabriz (Tabriz, Iran) developed a single-step solid-phase extraction (SPE) method to completely separate sterol oxidation products in food lipids.

Researchers from Universidad de Santiago de Compostela (Santiago de Compostela, Spain) developed a dispersive liquid-liquid microextraction sample preparation method to determine the antibacterial agent triclosan and its environmental transformation product methyl triclosan in water samples.

Polysaccharide-based chiral stationary phases (CSP) are widely used due to their wide chiral recognition ability. Several cellulose and amylose derivatives are extremely effective in the separation of a wide range of compounds of interest in the pharmaceutical industry.1 This work demonstrates the different chiral recognition capabilities of CSPs based on cellulose tris(3-chloro-4-methylphenylcarbamate) and cellulose tris(3,5-dimethylphenylcarbamate). Over 180 racemates of pharmaceutical interest were analysed on these two phases in normal (NP), polar-organic (PO) and reversed phase (RP) separation modes. Numerous examples including important classes of drug compounds as well as statistical data prove that cellulose tris(3-chloro-4 methylphenylcarbamate) offers a good alternative to the commonly used cellulose tris(3,5-dimethylphenylcarbamate) in the separation of difficult racemic mixtures.

Waters Corporation claims that by replacing traditional high performance liquid chromatography (HPLC) with its ACQUITY UltraPerformance LC (UPLC), acetonitrile consumption could be reduced by at least 70% without compromising productivity and performance.

Collaboration between MIP Technologies AB and sanofi-aventis has been announced, with the aim of developing molecularly imprinted polymers (MIPs) for the analysis of pharmacologically active peptides from plasma samples.

Hypercrosslinked polystyrene-type (solid-phase extraction) SPE materials exhibit a unique ability to enter pi-interactions with aromatic, heterocyclic and unsaturated compounds. This property permits selective extraction and pre-concentration of the above classes of species from non-polar media and fatty matrices. The principle has been exploited for developing analytical protocols to determine polar furan derivatives in mineral transformer oil, polyaromatic hydrocarbons (PAHs) in smoked fish and for the fractionation of polychlorinated aromatic compounds in environmental matrices.

This month E-Separations Solutions' Technology Forum looks at the topic of sample preparation and the trends and issues surrounding it. Joining us for this discussion are Tom Hall of Fluid Management Systems; Luke Roenneburg of Gilson, Inc.; and Ron Majors of Agilent Technologies.

Our work focuses on the synthesis of branched (functionalized) polydienes via a facile two-step synthesis. Despite the numerous strategies developed for the preparation of branched polymers in recent years, there is still a limited number of simple synthetic strategies based on common vinyl monomers.

Researchers from the University of the Basque Country (Bilbao, Spain) have compared two extraction techniques as preparation methods for analyzing organic pollutants polycyclic aromatic hydrocarbons, polychlorinated biphenyls, phthalate esters, nonylphenols, polybrominated biphenyls, and polybrominated diphenyl ethers in water samples.

Researchers from Bucknell University (Lewisburg, Pennsylvania) used electrophoretically mediated microanalysis in a capillary tube to perform a Jaffe reaction between creatinine and picrate.

Researchers from the Swedish University of Agricultural Sciences (Uppsala, Sweden) and the University of Tabriz (Tabriz, Iran) developed a solid-phase extraction method to separate sterol oxidation products in food lipids for analysis by gas chromatography (GC) and GC?mass spectrometry.

Metrohm UK (Buckingham, UK) has developed a method for analyzing samples of beer and intermediates for anions and cations ? alkali and alkaline earth metals ? using ion chromatography and voltammetry.

Scientists at the National Institute of Standards and Technology (NIST, Gaithersburg, Maryland) have developed a multiplexed capillary electrophoresis system and technique for high-throughput separations.

Bruker Daltonics (Billerica, Massachusetts) has released a method for the detection and quantification of melamine and cyanuric acid that can be used by food safety laboratories.

Waters Corporation (Milford, Massachusetts) has been named one of the Top Places to Work in Massachusetts as the result of an employee-based survey from The Boston Globe.

Pressure Biosciences, Inc. (South Easton, Massachusetts) has entered into an exclusive patent license agreement with the Battelle Memorial Institute (Columbus, Ohio.

The answer to the following reader question about degassing mobile phase solvents was supplied by LCGC?s ?LC Troubleshooting? columnist John Dolan.

The purpose of this application note is to demonstrate the use of the Oasis® HLB SPE Disk, with the Horizon Technology SPE-DEX® 4790 Extractor System.

Polysaccharide-based chiral stationary phases (CSP) are widely used due to their wide chiral recognition ability. Several cellulose and amylose derivatives are extremely effective in the separation of a wide range of compounds of interest in the pharmaceutical industry (1).

Varian, Inc. has published an application note entitled Enhanced ELSD Sensitivity of Parabens using Sub-Ambient Evaporation. Parabens are widely used as food additives, in personal care products and pharmaceutical formulations.

"Green HPLC" - A Status Review Björn-Thoralf Erxleben Comprehensive Two-Dimensional Gas Chromatography for Achieving Nitrogen Speciation in Middle Distillates F. Adam, F. Bertoncini, N. Lahoutifard, A.Addinall, D. Thiébaut, M.-C. Hennion and Marion Courtiade A Dissolved/Particulate Baseline Study of Polyaromatic Hydrocarbons in Particulate-Laden Water Friederich Werres and Robert S. Johnson News Tolerable levels for daily intake of melamine, a GPC/SEC training course, a company acquisition and a patent license agreement are featured this month. Incognito Overcoming the Acetonitrile Crunch... Follwing a decrease in the global production of acetonitrile, Incognito considers the alternatives for those using this as a solvent in important HPLC separations. Market Trends and Analysis Market Profile: Dissolution Testing Glenn Cudiamat

Upcoming short courses in the chromatography field.

Upcoming events in the chromatography field.

LCGC Europe June 2008 BPA Statement

LA Finalist - Novotny

I regularly receive e-mails from readers with a wide variety of questions. Some of these blossom into full-blown columns, but many are answered with just a short response. As I cleaned out my inbox recently, I chose a few of these to share. There is no central theme this month, but hopefully you will pick up some useful information from these topics related to practical operation of the liquid chromatography (LC) system.

LA Finalist - Wyatt