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Agilent (Palo Alto, California) recently announced plans to open a new training center in Shanghai, China.

In this initial instalment, several MS technologies and strategies currently being applied to characterize drug candidates in early stage development are presented.

The authors outline the ways in which forced degradation is used to develop a stability-indicating method and examine some of the method development and validation parameters critical to its success.

Agilent (Palo Alto, California) recently announced plans to open a new training center in Shanghai, China.

Reversed-phase high performance liquid chromatography (HPLC) is one of the most utilized forms of chromatography (1). The C8 and C18 stationary phases are the most widely used for reversed-phase HPLC. However, analysts occasionally encounter difficult separations for which selectivity, ruggedness, or reproducibility are not obtained easily using traditional C8 and C18 phases. These separations might require the use of novel or selective phases that interact with analytes in a manner different than C8 or C18 phases (2). These types of stationary phases separate compounds based upon selective stationary phase interactions such as steric recognition charge transfer or ?–? interactions (3). One class of selective or novel phases that have been used for a variety of separations are fluorinated phases (4). These fluorinated phases have provided an alternative and complementary separation for many analytes performed on C8 or C18 columns. Fluorinated phases can provide different elution orders, leading to..

LECO Corporation. For more information, visit the company's website at www.leco.com.

Waters Corporation. For more information, visit the company's website at www.waters.com.

2004 Author-Subject Index

Phenomenex, Inc. For more information, visit the company's website at www.phenomenex.com.

Wyatt Technology Corporation. For more information, visit the company's website at www.wyatt.com.

Gilson, Inc. For more information, visit the company's website at www.gilson.com.

Pickering Laboratories, Inc. For more information, visit the company's website at www.pickeringlabs.com.

Varian, Inc. For more information, visit the company's website at www.varianinc.com.

Analytical Sales and Services, Inc. For more information, visit the company's website at www.analytical-sales.com.

Alcott Chromatography, Inc. For more information, visit the company's website at www.alcottchromatography.com.

Waters Corporation. For more information, visit the company's website at www.waters.com.

Polymer Laboratories, Ltd. For more information, visit the company's website at www.polymerlabs.com.

Dionex Corporation. For more information, visit the company's website at www.dionex.com.

Spark Holland B.V. For more information, visit the company's website at www.spark.nl.

Alltech Associates, Inc. For more information, visit the company's website at www.alltechWEB.com.

Biochrom Ltd. For more information, visit the company's website at www.biochrom.co.uk.

BIONISIS. For more information, visit the company's website at www.bionisis.com.

Hamilton Company. For more information, visit the company's website at www.hamiltoncompany.com.

Advanced Chemistry Development. For more information, visit the company's website at www.acdlabs.com.

Hitachi High Technologies America. For more information, visit the company's website at www.hitachi-hta/lshome.com.

Kin-Tek Laboratories, Inc. For more information, visit the company's website at www.kin-tek.com.

Gilson, Inc. For more information, visit the company's website at www.gilson.com.

Shimadzu Scientific Instruments, Inc. For more information, visit the company's website at www.shimadzu.com.