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In this episode, “LC Column Hardware Evolution and its Role in Sustainability” brought to you by Advanced Materials Technology, Brett Paull Ph.D., Director of the ARC Training Centre for Hyphenated Analytical Separation technologies (HyTECH) at the University of Tasmania discusses the relationship of HPLC column technology and sustainability at the laboratory level.

Mistakes in the QC lab come in many forms: forgotten samples, incorrect solvent levels, or not verifying correct system performance. These mistakes can lead to repeated procedures and possibly time-consuming investigations, compromising lab productivity and efficiency. When combined, the Alliance iS HPLC System and Empower Software version 3.8.0 provide several new features designed to reduce errors and improve productivity in QC labs. Join Neil Lander and Denise Heyburn as they provide an overview of the top three advanced capabilities unlocked by combining the intuitively simple Alliance iS HPLC System with the latest version of Empower Software.

Pharmaceutical science has used the same slow analytical quality testing techniques for more than 40 years. Dr. Fred Regnier, CTO of Novilytic and one of the world’s top analytical chemists, explains how a new method is being utilized to expedite the molecular analysis of antibodies and to eliminate sample prep and mass spectrometry.

MALS detection coupled with AEX chromatography can aid in the characterization of AAVs.

Joseph Glajch, Ph.D., shares his expert perspective on the future of LC bio separations, hinting at the exciting possibilities that lie ahead for this transformative field.

James Edwards, an Application Scientist and Chromatographer at Porvair Sciences, discusses the challenges and advancements in solid-phase extraction (SPE) as a sample preparation technique for chromatography.

Polymers are gaining more attention in many new fields such as pharmaceutical applications. However, optimizing the final properties of the polymers associated with these new application areas is challenging for chemists and analysts. Polymer architecture plays a crucial role to optimize the end use or process-related properties. Size exclusion chromatography in combination with advanced detectors such as light scattering, viscometer, and refractive index is a powerful tool for the comprehensive characterization of macromolecules with various architectures. In this podcast, Dr. Subin Damodaran will explain how to understand the structural properties of a polymer by providing their molecular sizes such as radius of gyration (Rg ) and hydrodynamic radius (Rh), and intrinsic viscosity.

Quantitative measurement of biotherapeutic and clinically important biomarker proteins using LC-MS/MS has seen great development in the last 15 years. Stable Isotope Labelled Internal Standards are a cornerstone of accurate quantitation and there are several options ranging from signature peptides to “winged” longer peptides or full 13C and/or 15N labelled proteins to choose from. In this video Kevin Ray, Kwasi Mawunyega and Anders Fridstrom will discuss pros and cons with different SIL IS approaches as well as similarities and differences between biopharmaceutical bioanalysis and biomarkers for disease research & diagnosis.

Moderator Joshua Hayden of Norton Healthcare discusses mass spectrometry with Stefani Thomas of the University of Minnesota.

Moderator Joshua Hayden of Norton Healthcare discusses mass spectrometry with Fred Strathmen of Mobil Lion Systems and Heather Stieglitz of The Ohio State University Wexner Medical Center.

Precisely characterize polymers by using advanced detection and analytical techniques.

A successful strategy for speeding the product-development cycle without impairing innovation or quality.

Practical advice for successfully balancing safety, eco-friendliness, performance, and productivity during chromatography assessments.