April 30th 2024
Scientists from the Chinese Academy of Inspection and Quarantine recently published a review on how green solvents can further the evolution of microextraction techniques.
Analysis of Boronic Compounds as Potential Mutagenic Impurities in Drug Substances By GC–MS
December 1st 2021This novel gas chromatography (GC)–MS approach enables analysis of the suspected mutagens bis(pinacolato)diboron (BPD) and tetrahydroxydiboron (BBA) found at low-levels in certain intermediates and active pharmaceutical ingredients (APIs), even in the presence of boron from other sources.
The LCGC Blog: ACS SCSC: What We Do and Who We Are
November 30th 2021In this month’s blog, we provide information about the Subdivision on Chromatography and Separations Chemistry (SCSC) of the Analytical Division of the American Chemical Society (ACS), sharing our main goals and introducing our newly appointed executive board members.
The LCGC Blog: Polymers, Macromolecules, and Nanomaterials in the Separation Science Curriculum
August 2nd 2021In 2015, the American Chemical Society’s Committee on Professional Training added a requirement to the ACS degree certification program that undergraduates learn about macromolecules, supramolecular aggregates, and nanomaterials (MSN). This requirement can be met by a specialized course in these topics, but many programs are also choosing the distribute these topics across the curriculum.
Decomposing animal tissue releases volatile organic compounds (VOCs), of interest in forensic science. We describe the use of GC×GC–qMS/FID retrofitted with a reverse fill/flush (RFF) flow modulator for analyzing these VOCs in a tropical climate.
Identification of Microplastics in Environmental Monitoring Using Pyrolysis–GC–MS Analysis
April 7th 2021Pyrolysis–gas chromatography–mass spectrometry has advantages for the analysis of environmental microplastic samples compared to other leading analytical methods, including spectroscopic techniques.
Flying High with Sensitivity and Selectivity:- GC–MS to GC–MS/MS
February 1st 2021Mass spectrometry (MS) is the most powerful detector available for gas chromatography (GC). This article reviews the fundamentals of MS/MS and how they relate to MS as a detector for GC, then examines scenarios where use of GC–MS/MS can solve complex problems.
Detecting Biomarkers in Breath using GC–MS
July 7th 2020Biomarker studies using exhaled breath are rapidly emerging as a technique for early disease detection and precision medicine. By offering a completely non-invasive experience for patients as an alternative to painful biopsy procedures. A new approach has the potential to enhance patient compliance, while making clinical workflows simpler. Exhaled breath analysis, however, requires a highly sensitive analytical technique capable of accurately measuring the broad range of volatiles present in breath. In this article, we present a proof-of-concept study to demonstrate a reliable and sensitive method to detect analytes in breath samples. Using high‑resolution accurate mass (HRAM) mass spectrometry (MS), the method validates how low- and high-abundance biomarkers can be quantified from exhaled breath.
Beat the Heat: Cold Injections in Gas Chromatography
July 1st 2020In gas chromatography, heating the sample in the inlet can lead to sample losses and loss of quantitative reproducibility, but these problems can be avoided using cold sample introduction. This article describes various types of cold injection and how they can benefit the analyst.
Achieving Highly Sensitive Dioxin Analysis with Novel GC–MS Methods
January 20th 2020PCDDs, PCDFs, and PCBs are toxic compounds categorized as POPs and are ubiquitous throughout the world. Detecting trace levels of PCDD and PCDF is important to monitor food supplies and to ensure industrial emissions meet regulatory standards. In line with the ongoing innovation in dioxin analysis technology, the US EPA is currently evaluating a new method-APGC–MS/MS-for PCDD and PCDF confirmatory analysis. Joe Romano and Douglas Stevens from Waters Corporation discuss the benefits of this new method.
Diagnosing Cancer Using Cerumen and HSGC–MS
November 6th 2019The Column spoke to Nelson Roberto Antoniosi Filho, a professor at the Chemistry Institute of the Federal University of Goiás (UFG), in Goiânia, Brazil, about his development of a gas chromatography–mass spectrometry (GC–MS) method for cancer diagnosis using cerumen.