GC–MS

QuEChERS has been updated to suit modern instrumentation. Now also “efficient and robust,” QuEChERSER is a “mega-method” that covers a wider polarity range.

This novel gas chromatography (GC)–MS approach enables analysis of the suspected mutagens bis(pinacolato)diboron (BPD) and tetrahydroxydiboron (BBA) found at low-levels in certain intermediates and active pharmaceutical ingredients (APIs), even in the presence of boron from other sources.

In this month’s blog, we provide information about the Subdivision on Chromatography and Separations Chemistry (SCSC) of the Analytical Division of the American Chemical Society (ACS), sharing our main goals and introducing our newly appointed executive board members.

This study illustrates the importance of column selection during GC method development.

In 2015, the American Chemical Society’s Committee on Professional Training added a requirement to the ACS degree certification program that undergraduates learn about macromolecules, supramolecular aggregates, and nanomaterials (MSN). This requirement can be met by a specialized course in these topics, but many programs are also choosing the distribute these topics across the curriculum.

HS-SPME-GC–MS was combined with OPLS-DA data analysis to tentatively identify eight chemical markers to differentiate the geographical origins of cigar leaf samples.

Decomposing animal tissue releases volatile organic compounds (VOCs), of interest in forensic science. We describe the use of GC×GC–qMS/FID retrofitted with a reverse fill/flush (RFF) flow modulator for analyzing these VOCs in a tropical climate.

Pyrolysis–gas chromatography–mass spectrometry has advantages for the analysis of environmental microplastic samples compared to other leading analytical methods, including spectroscopic techniques.

This article looks at the benefits of combining dynamic headspace sampling (DHS) with capillary GC–TOF-MS as a tool for untargeted analysis of aroma compounds in food and beverages. Applications for the analysis of strawberry yoghurt, chocolate, and red wine are described.

“GC Connections” presents the column’s annual review of new developments in the field of gas chromatography seen at Pittcon and other venues in the past 12 months.

A novel analysis technique has been developed for the determination of microplastics (MPs) in complex environmental samples using thermal extraction desorption gas chromatography–mass spectrometry (TED-GC–MS).

Mass spectrometry (MS) is the most powerful detector available for gas chromatography (GC). This article reviews the fundamentals of MS/MS and how they relate to MS as a detector for GC, then examines scenarios where use of GC–MS/MS can solve complex problems.

By moving from GC–MS to GC–MS/MS, you can have both universal and selective detection along with low detection limits. Here’s how it works.

Laura McGregor, Stefan Koschinski, and Elinor Hughes, SepSolve Analytical Assessing aroma profiles with high-capacity sorptive extraction combined with GC×GC–TOF-MS and powerful data mining software.

The Column spoke to Martin Giera of Leiden University Medical Center about his innovative research using GC–MS in bioanalysis applications.

A supported liquid extraction (SLE) and fast gas chromatography–tandem mass spectroscopy (GC–MS/MS) method, used in multiple reaction monitoring (MRM) mode, was developed for the analysis of semivolatile organic compounds (SVOCs) in environmental samples, according to the updated EPA Methods 625.1 and 8270E. This method requires minimal sample handling and yields significant throughput and productivity gains in the laboratory.

An introduction to this special issue by our guest editor.

A comprehensive monitoring protocol has been developed using GC–MS/ECD in selective ion monitoring (SIM) mode, with injection performed by solid-phase microextraction (SPME) and headspace (HS). This single system has been configured to analyze for all taste and odor (T&O) compounds in Standard Method 2170, with minimal changing of columns, injectors, or SPME fibers between methods.

A panel discussion on the latest advances and future developments in gas chromatography mass spectrometry (GC–MS).

In the present research, similar chromatography fingerprints were obtained using finely-tuned cryogenic-modulation (CM) and flow-modulation (FM) comprehensive two-dimensional gas chromatography–mass spectrometry (GC×GC–MS) experimental conditions.

Biomarker studies using exhaled breath are rapidly emerging as a technique for early disease detection and precision medicine. By offering a completely non-invasive experience for patients as an alternative to painful biopsy procedures. A new approach has the potential to enhance patient compliance, while making clinical workflows simpler. Exhaled breath analysis, however, requires a highly sensitive analytical technique capable of accurately measuring the broad range of volatiles present in breath. In this article, we present a proof-of-concept study to demonstrate a reliable and sensitive method to detect analytes in breath samples. Using high‑resolution accurate mass (HRAM) mass spectrometry (MS), the method validates how low- and high-abundance biomarkers can be quantified from exhaled breath.

In gas chromatography, heating the sample in the inlet can lead to sample losses and loss of quantitative reproducibility, but these problems can be avoided using cold sample introduction. This article describes various types of cold injection and how they can benefit the analyst.

PCDDs, PCDFs, and PCBs are toxic compounds categorized as POPs and are ubiquitous throughout the world. Detecting trace levels of PCDD and PCDF is important to monitor food supplies and to ensure industrial emissions meet regulatory standards. In line with the ongoing innovation in dioxin analysis technology, the US EPA is currently evaluating a new method-APGC–MS/MS-for PCDD and PCDF confirmatory analysis. Joe Romano and Douglas Stevens from Waters Corporation discuss the benefits of this new method.

The Column spoke to Nelson Roberto Antoniosi Filho, a professor at the Chemistry Institute of the Federal University of Goiás (UFG), in Goiânia, Brazil, about his development of a gas chromatography–mass spectrometry (GC–MS) method for cancer diagnosis using cerumen.

In this study, the intentional incorporation of an air bubble into a solvent droplet is proposed for fully automated bubble-in-drop microextraction–gas chromatography–mass spectrometric (BID-GC–MS) analysis of selected organochlorine pesticides as model analytes.