November 24th 2023
Scientists recently used laser desorption ionization mass spectrometry (LDI-MS) to detect toxic alkaloids in traditional Chinese medicines (TCM).
November 23rd 2023
A group of scientists recently analyzed the metabolomics of individual cells using a pneumatically assisted (PA) nanospray desorption electrospray ionization (nano-DESI) probe of their own creation.
November 13th 2023
A group of scientists created a minireview of the versatile nature of ion mobility–mass spectrometry (IM–MS), and how the technique can be used in different scenarios.
November 10th 2023
A group of scientists from the Luxembourg Institute of Science and Technology (LIST) tested different methods of using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) to analyze human skin cells.
November 2nd 2023
Scientists from the University of Maryland have created a system to analyze changes in a brain’s chief circadian pacemaker.
Thermo Fisher Scientific Releases New Ion Chromatography System
The new technology can be used by analytical scientists working in a variety of industries including food and beverage, oil and gas, and more.
The Effect of Amino Acids on Protein Stability During Electrothermal Supercharging
Scientists from Western Michigan University tested how amino acids can affect protein stability during electrothermal supercharging.
MALDI-MS and SIMS Combined to Detect Ovarian Cancer
Scientists from Washington and Connecticut have created a new system to detect epithelial ovarian cancer (EOC).
AIU–IM–MS Unlocks Precision in Assessing Therapeutic Antibody Stability
Researchers in Tianjin, China, have employed all ion unfolding–ion mobility–mass spectrometry (AIU–IM–MS) to enhance the differentiation of therapeutic polyclonal antibodies, offering insights into improvements in conformational stability and advantages in cost-effectiveness.
Molecular Dynamics-Based Model Enhances Ion-Neutral Collision Simulations in Mass Spectrometry
A molecular dynamics trajectory approach was shown by a research team to improve ion mobility predictions with deviations of mere percentage points from experimental values.
Portable and Field‑Deployable Liquid Chromatography for Environmental Studies
Liquid chromatography (LC) is a platform technology amenable to portable and “at-site” or deployable applications. This has awoken end-users to new possibilities and potential cost savings and process improvements.
Gas Chromatography Reveals Clues to Martian Amino Acids: A Step Towards Understanding the Red Planet's Potential for Life
Researchers from the University of Poitiers and CNES have developed a groundbreaking gas chromatography method, detailed in the journal Chemosensors, which enables the detection of amino acid-like compounds on Mars, offering a vital tool in the quest for extraterrestrial life.
Event Preview: ISSS 2023
The 27th International Symposium on Separation Sciences (ISSS 2023) will be held 24–27 September 2023 in Cluj-Napoca, Romania. Here’s a sneak preview of what attendees can look forwards to.
Scientists Test New Method for Combatting Antimicrobial Resistance
Researchers from the University of Washington have begun testing a new system to fight antimicrobial resistance by combining liquid chromatography (LC) with ion mobility (IM) separation.
Highlights from the 51st International Symposium on High Performance Liquid Phase Separations and Related Techniques
This instalment of “Column Watch” presents many of the highlighted topics and trends observed at this exceptionally well-run symposium.
Reflecting on Ion Chromatography and Urine Analysis
To further understand what role ion chromatography (IC) plays in urine analysis, scientists investigated urine pretreatment techniques and how IC systems are designed and developed to measure various chemicals.
GC Connections: Basic Care and Feeding of Your Detector
This instalment explores the challenges involved in detecting the effluent from a capillary gas chromatographic column and summarizes the many detector options.
New European PFAS Thresholds Put Focus on Analysis of ‘Unknown’ Chemicals
Bjorn Berendsen of Wageningen University & Research said at NACRW 2023 that among more than 6,000 suspected per- and polyfluoroalkyl substances (PFAS), detailed information is known about relatively few.
Advancing Gas Chromatography: Exploring the Power of Silver(I) Ion-Based Stationary Phases for Olefin/Paraffin Separation
Researchers compare the separation efficiency of olefins and paraffins using stationary phases containing silver(I) ions in ionic liquid (IL) and polymeric ionic liquid (PIL) matrices for gas chromatography techniques.
Breakthrough Method for Peptide Purity Analysis: Gas Chromatography–Isotope Dilution Infrared Spectrometry Takes Center Stage
Researchers have introduced a novel primary method utilizing gas chromatography–isotope dilution infrared spectrometry (GC–IDIR) for accurate peptide purity analysis.
Automatic z-Axis Correction Improves Mass Spectrometry Imaging of Uneven Surfaces
A new method for automatic z-axis correction during mass spectrometry imaging of uneven surfaces has been developed, allowing for accurate molecular analysis of complex samples. This advancement enhances the reliability and reproducibility of mass spectrometry imaging, enabling researchers to visualize the spatial distribution of molecules in challenging samples with uneven topographies.
Department of Energy Scientists Use Mass Spectrometry to Identify Unknown Compounds
Scientists from the Pacific Northwest National Laboratory are using high-resolution ion mobility spectrometry-mass spectrometry to identify unknown compounds.
Breakthrough Imaging Technique Reveals Acetaminophen Distribution in Kidneys with Unprecedented Precision
New research using matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) has revealed the distinct distributions of acetaminophen and its metabolite in the kidneys at an unprecedented resolution of 10 μm. The study, conducted by Mitsutoshi Setou and his team from Hamamatsu University School of Medicine in Japan, provides valuable insights into drug distribution and metabolism, enhancing our understanding of the pharmacokinetics and potential nephrotoxicity of acetaminophen.
New Findings Shed Light on Formation and Analysis of Doubly Charged Lipid-Metal Ion Complexes
Researchers have discovered that phospholipids form doubly charged lipid-metal ion complexes during electrospray ionization (ESI), providing valuable insights into the analysis of phospholipid structures.
New Method Enables Accurate Analysis of Aminoglycoside Antibiotic Residues in Aquatic Products
Researchers have developed an ultrahigh-pressure liquid chromatography (UHPLC)—tandem mass spectrometry (MS/MS) method for the simultaneous determination of 10 aminoglycoside antibiotics in aquatic products.
The Role of LC–MS/MS to Assess Chemical Exposure
At HPLC 2023, Erin Baker held a lecture on how using liquid chromatography and mass spectrometry together can help scientists further understand diseases that can arise from chemical exposure.
Successful Analysis of Protein Biopharmaceuticals Using Ultra-Short Columns
Davy Guillarme of the University of Geneva said in a talk at HPLC 2023 that short columns have shown promise, but ultrahigh-performance liquid chromatography (UHPLC) instrumentation is not yet optimized to realize their benefits.
Automated Material Discovery With LC–MS
At HPLC 2023, Hyukju Kwon hosted a lecture on the roles LC–MS and artificial intelligence can have in autonomous material discovery.
New Study Reveals Promising Biomarkers for Rapid Breast Cancer Diagnosis Using Mass Spectrometry Imaging
Researchers have discovered diacylglycerols as potent biomarkers for the rapid diagnosis of breast cancer, using mass spectrometry imaging. This breakthrough study offers new possibilities for improved intraoperative assessment and personalized treatment strategies.
Breakthrough MDLC–MS Method Enhances Characterization of Therapeutic Antibody Charge Variants
Scientists have developed a breakthrough MDLC–MS method for in-depth characterization of charge variants in therapeutic antibodies. The innovative approach enables the detection and evaluation of rare charge variants, facilitating improved safety and efficacy in antibody development.
Unveiling Metabolite Interference for Reliable LC–MS Targeted Metabolomics Analysis
New research emphasize the importance of identifying metabolite interference in LC–MS targeted metabolomics analysis to ensure accurate results. The study highlights the need for thorough investigation and resolution of metabolite interferences for reliable metabolite measurement in targeted metabolomics.
LC–MS With Chemical Isotope Labeling Provides Sensitive Analysis of Central Carbon Metabolism Intermediates
A simultaneous, single-run analysis was sought for metabolites of the central carbon metabolism pathway, which is closely related to the occurrence and development of most diseases in humans.
Breakthrough Method Enables Comprehensive Analysis of Secondary Formation Markers in Ambient Organic Aerosols
New method enables comprehensive analysis of secondary formation markers in ambient organic aerosols, providing valuable insights into atmospheric pollutants using HPLC–ESI-TOF-MS.
Efficient Sample Preparation and High-Capacity Columns for Successful Food and Beverage Analysis
Overcoming the challenges of food and beverage analysis with ion chromatography (IC).
June 2023 News in Brief
Agilent and Metrohm join forces, and Waters Corporation completes acquisition
of Wyatt Technology.
2 Commerce Drive Cranbury, NJ 08512