Liquid Chromatography (LC/HPLC)

Researchers used metabolomics analysis to measure different harvest times during the whole growing period of ligustri lucidi fructus (LLF), a traditional Chinese medicinal herb.

Scientists from Egypt have developed a green reversed-phase high-performance liquid chromatography (RP-HPLC) method to determine the amounts of methionine and paracetamol in different mixtures.

To combat fraudulent sales of low-aged ginseng disguised as high-aged ginseng, scientists from Shanghai University of Traditional Chinese Medicine created machine learning models to predict the ages of ginseng samples.

An efficient solvent system screening approach that streamlines fractionation of compounds with similar UV absorption eliminates the need for individual partition coefficient calculations, and coupled with preparative HPLC purification, led to the isolation of seven c-glycosyl flavonoids and an amino acid from barley seedlings.

Scientists from Zhejiang, China recently conducted experiments meant to properly characterize sucrose ester isomers from tobacco samples.

Scientists from Ames National Laboratory in Ames, Iowa recently analyzed silver(I) and copper(I) ions to understand the environmental factors when they are altered.

This article presents a multimodal approach for students with severe visual impairment or blindness, to encourage them to learn more about chromatographic processes.

Troubleshooting continues to evolve constantly, changing how we overcome issues such as chemical causes of peak tailing.

Gas chromatography can be used in combination with molecular spectroscopy to provide structural and quantitative information on a variety of sample types.

We provide a high-level overview of Current Good Manufacturing Practice (cGMP) regulations and their impact on the analytical chemist in the pharmaceutical industry.

A team of scientists from Nanjing, China, have created a low-cost efficient online derivatization high-performance liquid chromatography (HPLC)-ultraviolet (UV) detector system, which they used to detect mono- and oligo-saccharides.

Researchers from Vrije Universiteit Brussel and Sapienza Università di Roma shed light on the characteristics of mass transfer paths in liquid chromatography.

Among the chlorinated byproducts of water disinfection within the fresh-cut industry, haloacetic acids (HAAs) are known to pose a consumer health risk if they remain present in the treated product.

The α-glucosidase inhibitors (AGIs) were isolated from extracts of Agrimonia pilosa Ledeb (APL), which is a perennial herb used in traditional Chinese medicine (TCM).

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A novel lenvatinib stability-indicating method, developed through a quality by design (QbD) approach and embracing principles of green chemistry, offers a robust solution for ensuring the drug's stability under various conditions.

Researchers have developed a meticulous method for analyzing impurities in a product used for early treatment of breast cancer in premenopausal and perimenopausal women, shedding light on the product’s degradation pathways.

Researchers have developed a method for the simultaneous determination of betulinic acid, oleanolic acid, and ursolic acid in jujube extract, utilizing high performance liquid chromatography with ultraviolet detection (HPLC–UV) coupled with multilayer perceptron networks, offering a more efficient alternative to classical HPLC techniques.

Three different metrics were used experimentally, based on measurements of both NIST Standard Reference Material (SRM) 1950 and data obtained from murine kidney tissue.

Researchers at two US colleges have utilized ion mobility spectrometry–mass spectrometry (IMS-MS) to analyze nonenzymatic posttranslational modifications and peptide cleavages in a single peptide system, revealing insights into critical biomarkers for age-related diseases.

FDA scientists have expanded the number of analytes in their analytical method for per- and polyfluoroalkyl substances (PFAS), partly in response to updated guidance out of the European Union (EU) on method parameters and limits of quantification (LOQs).

Valérie Pichon's review in Analytical and Bioanalytical Chemistry delves into sophisticated liquid chromatography techniques for detecting albumin adducts, vital biomarkers in retrospective mustard agent exposure monitoring, offering a broader window of detection than urine-based methods.

A comprehensive analytical approach utilizing online two-dimensional liquid chromatography coupled with hybrid linear ion trap orbital trap mass spectrometry, has enabled the in-depth analysis of Huangqi Guizhi Wuwu decoction, identifying 170 chemical constituents and offering insights into its complex chemical composition and potential therapeutic properties.

Researchers have developed a highly sensitive and cost-effective HPLC-UV method for simultaneously detecting 36 D/L-amino acids in foods, opening new avenues for food quality control and shedding light on the significance of D-amino acids in nature.

Liquid chromatography (LC) is a platform technology amenable to portable and “at-site” or deployable applications. This has awoken end-users to new possibilities and potential cost savings and process improvements.