Liquid Chromatography (LC/HPLC)

Scientists from Chongqing University Cancer Hospital recently developed a new system for analyzing the potential impact of retention time (RT) prediction on targeted LC–MS-based lipidomics.

Brivaracetam has been approved for prescription use in the last decade for treatment of patients experiencing focal, or partial, seizures.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from Florida State University used Marfey’s reagent and reversed-phase liquid chromatography–tandem mass spectrometry (LC–MS/MS) to analyze D-amino acids.

In this installment, we apply the concepts developed in last month’s installment by demonstrating how they can be used to help troubleshoot problems in LC involving pressure and flow.

This article covers liquid chromatography columns and accessories commercially released after Pittcon 2023 through the 2024 conference.

Recent advances in coating techniques and improved polymers employed as gas chromatographic stationary phases have resulted in commercializing low phase ratio capillary column technology with respectable chromatographic efficiency and inertness.

Researchers propose a suite of batch effect removal neural networks in large liquid chromatography-mass spectrometry experiments to maximize sample classification performance between conditions.

U.S. Environmental Protection Agency (EPA) Method 1633 signifies a pivotal shift in per- and polyfluoroalkyl substance (PFAS) determination, extending beyond drinking water.

Yelena Sapozhnikova from the United States Department of Agriculture spoke to The Column about her innovative research investigating PFAS in plastic food storage bags using targeted and non-targeted liquid chromatography–tandem mass spectrometry.

Michelle Colgrave of Edith Cowan University and Australia’s national science agency is the recipient of the 2024 Harvey W. Wiley Award.

French scientists recently created a new analytical method for quantifying micropollutants in different species of gammarids.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from Hangzhou Medical College recently recorded the effectiveness of novel quality control strategies for the determination of vitamin D using liquid chromatography–tandem mass spectrometry (LC–MS/MS).

HRIM-MS has shown unique capabilities when used to analyze cyclic peptide therapeutics, and enhances the analysis of biopharmaceuticals by efficiently filtering out interfering compounds for direct analysis within a complex mixture. These findings demonstrate the technique's utility and versatility.

An examination of how chromatography could be used to solve the water crisis in the American southwest.

Scientists from China Pharmaceutical University developed a liquid chromatography-tandem mass spectrometry (LC–MS/MS)-based method for determining the presence of anti-colorectal cancer drugs in human plasma.

In this edition of "The LCGC Blog," Jonathan Shackman discusses the differences between chromatographers and chromatography users, as well as advancements that have made chromatography a more accessible field.

Scientists from the Chinese Academy of Inspection and Quarantine recently published a review on how green solvents can further the evolution of microextraction techniques.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.

Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.

The serum/plasma estradiol is useful for diagnosis, pathology, and therapeutic efficacy monitoring of estrogen-dependent diseases, according to the authors.

Scientists from Anhui University of Chinese Medicine in Hefei, China recently investigated the mechanisms behind what makes huachansu tablets, a type of traditional Chinese medicine (TCM), effective against liver cancer.

On the occasion of Earth Day, University of Wisconsin-Madison graduate student and chemist Katelyn Michael speaks with LCGC about the methods she has been using to attempt to degrade known PFAS.