Liquid Chromatography (LC/HPLC)

Sara E. Kern and her team of the U.S. Food and Drug Administration (FDA) tested different analysis methods for rapidly screening for poppy seeds in food samples.

A session focusing on important developments in high-throughput analysis in the pharmaceutical sector using LC–MS kicked off Monday morning at Pittcon 2024.

Alyssa Sanchez of Florida International University presented her research on profiling the decomposition of heroin from South America, Mexico, Southwest and Southeast Asia.

Lidia Montero and Miguel Herrero from the Institute of Food Science Research in Spain discuss the evolving role of comprehensive two-dimensional liquid chromatography (LC×LC) and multi-second dimension LC×LC (multi-2D LC×LC) in food analysis.

The 18th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology will take place from 28–31 May 2024 in Leuven, Belgium.

Researchers from Nanjing University of Chinese Medicine leveraged ultrahigh-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) and network pharmacology to identify potential quality markers of three processed Qingpi products and elucidate their mechanism in liver disease treatment.

Researchers employed advanced chromatography and mass spectrometry techniques to unravel the chemical components and metabolites of Lingbao Huxin Dan, pinpointing its therapeutic potential for cardiovascular ailments.

A recent study examined using liquid chromatography methods for determining analytes in antioxidative molecules.

Wolfgang F. Lindner and Martina Catani are the winners of the 17th annual LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, respectively. These awards honor the work of talented separation scientists at different stages in their career. The award winners will be honored in March in an oral symposium at the Pittcon 2024 conference in San Diego, California.

High performance anion-exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD) is a potential method of choice for the analysis of carbohydrates.

In this installment, I illustrate the impact of different gradient delay volumes when transferring a method between instruments and discuss some strategies that can be used to mitigate these challenges.

Scientists in Mexico developed a new method for detecting herbicides in agricultural soil, being based on techniques like 9-fluorenylmethyl chloroformate (FMOC-Cl) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).

Weronika Hewelt-Belka, an assistant professor at Gdańsk University of Technology in Poland, answers questions about her research analyzing GM3 gangliosides in human milk, elucidating their molecular distribution and dynamic changes throughout lactation.

High performance liquid chromatography (HPLC) was paired with both diode array and fluorescence detection (DAD and FLD, respectively) to measure Edam cheese for its total and acid-soluble whey content.

This study of the perennial herb also known as madimak (or Indian knotgrass) aimed to simultaneously determine phenolic compounds to gain more insights into their antioxidant or antimicrobial capabilities.

A recent study from the Shangdong Academy of Chinese Medicine examined chicory using a novel UHPLC–HRMS technique and rats as the test subject.

Herbert Knauer founded his namesake laboratory equipment company with his wife Roswitha in Berlin in 1962.

Scientists from Utah and Ireland recently created a liquid chromatography–mass spectrometry (LC–MS) analytical method capable of detecting phototoxins in essential oils.

Researchers from Italy, Spain, and Turkey employed online high performance liquid chromatography (HPLC) to analyze various extracts of Leonurus cardiaca, revealing potent antioxidant properties and promising antibiofilm activity.

LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.

A review of advances in mRNA analysis using LC and LC–MS.

Scientists in Xi’an, China have created a novel system for the analysis of cell membranes, based around haloalkane dehalogenase protein tag (HALO)-tag technology. Their research was published in Talanta.

This experiment introduced a deep eutectic solvent developed in conjunction with a pH-induced phase transition combined with high performance liquid chromatography (HPLC) for efficient trace determination of bisphenol A (BPA) in water samples.

In this LCGC Blog, the author explores stationary phases that incorporate permanent or induced charges within, or alongside, hydrophobic alkyl silica type bonded ligands.

In addition, the company gained nearly 400 square meters of office space thanks to the renovation of a building adjacent to its Berlin headquarters.

Scientists from Hunan University of Chinese Medicine and Zhengzhou University in Zhengzhou, China recently created a new system for extracting catecholamines (CAs) in urine samples.

Researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College categorize the cardioprotective effects and other characteristics of flavonoids from the species commonly known as Chinese rosewood.

This research introduces a novel chromatographic method for the simultaneous determination of bisoprolol fumarate, carvedilol, and furosemide in both their pure and pharmaceutical dosage forms, offering a cost-effective, time-saving solution for routine drug quality control analysis.