Liquid Chromatography (LC/HPLC)

An overview of different approaches for the qualitative and quantitative analysis of polysorbates.

On a fundamental level, equilibrium and diffusion define chemical separations.

Understanding separation principles is the key to success. Here's why.

A new report from Meticulous Research attributes the growth to the development of antibody-based therapeutics and biosimilars.

Plant growth regulators (PGRs) have significant effects on plant physiological processes, but the complex matrices of plants, along with polarity and instability issues inherent with PGRs, complicate trace analysis of these compounds.

Sauce-flavor or sauce-aroma baijiu, one variant of a popular Chinese liquor, is treated with a fermentation starter called daqu, giving the concoction a unique taste profile, and scientists want more information about how it can inform the manufacturing of higher-quality baijiu.

During the North American Chemical Residue Workshop, scientists discussed predicting liquid chromatographic retention times to identify contaminants.

Researchers have developed a polybutylene terephthalate-based stationary phase for ion-pair-free reversed-phase liquid chromatography.

Among the compounds of concern found in the samples were nicotine-related alkaloids, psychoactive cannabinoids, and chemicals that promoted inflammation of the respiratory system.

While both branched-chain fatty acids (BCFAs) and straight-chain fatty acids (SCFAs) were analyzed, the profiling of BCFAs was considered especially important for future metabolomics and lipidomics studies.

High-throughput proteomic research has been hampered by the limited peak capacity of one-dimensional liquid chromatography (1D-LC) separation performance.

A study conducted by researchers at Rowan University explores column selection in compact capillary liquid chromatography (LC) systems.

The two-dimensional liquid chromatography (2D-LC) separations were supplemented by the use of capillary-channeled polymer (C-CP) fiber columns.

Researchers have developed a trapping mode two-dimensional liquid chromatography (2D-LC) workflow for the enrichment and quantification of low-level impurities in pharmaceutical development, offering a promising approach for enhancing impurity monitoring in the pharmaceutical industry.

A water-resistant, highly adsorptive molecularly imprinted polymer was developed to address the issues of unstable adsorption performance and high organic solvent consumption in traditional materials.

A research team has developed a new method for the online measurement of tetraethyllead (TEL) in aqueous samples. The approach utilizes magnetism-enhanced in-tube solid phase microextraction (ME/IT-SPME) coupled with high performance liquid chromatography (HPLC) and diode array detection (DAD).

Authentication of popular ginseng-based products has been difficult and has caused confusion in quality control between traditional Chinese medicine (TCM) and Chinese patent medicine (CPM).

A research team has investigated the impact of hydrophilic/lipophilic balance (HLB) on the porogenic properties of non-ionic surfactants for chromatographic separation.

Researchers have recalibrated polyparameter linear free energy relationships (PP-LFERs) for low-density polyethylene (LDPE) passive samplers. By utilizing a robust regression method and reliable partition coefficients and solute descriptors, the recalibrated models exhibited improved predictive performance, accurately estimating LDPE-water and LDPE-air partition coefficients across a wide range of compounds.

Although closantel (CLO) is well-regarded as a curative antiparasitic drug, even low doses have been found to cause serious side effects in the human retina and central nervous system.

OECD-compliant amino acid derivative assay (ADRA) testing and method transfer to UHPLC conditions is presented.

Forsythiae fructus is a traditional Chinese medicinal herb that has been used to treat various ailments such as inflammation, fever, and infections.

LCGC was on the ground at HPLC 2023.

Examining the role that LC–MS/MS plays in metabolomics, and metabolomics’ growing importance in the field of disease biology.

This article details a recent experiment that demonstrates how nonspecific interactions can be prevented by using metal-free or low adsorption flow paths.