Application Notes: General

A point-of-care LC system that is compact, reliable, and easy to use. The Axcend Focus LC is efficient, allowing for informed decisions at the time of need.

Repeatable analyses of API dissolution. An Extra Strength Excedrin® analgesic tablet was dissolved in a 200 mL solution (97% water; 3% ACN; and <0.1% TFA).

Portable HPLC to detect and separate 5 cannabinoids present in 50 mg of a hemp-variant of cannabis flowers and 12 additional cannabinoids present in a Restek standard.

Lipid-based nanoparticles (LNPs) are effective non-viral vectors for delivering messenger RNA products (mRNA), most notably used for vaccine production against the recent SARS-CoV-2 pandemic. In this executive summary, you will discover a robust and high-throughput kit-based analysis of nucleic acids extracted from different mRNA-LNP samples.

Mobile phase pH is a powerful tool for separating neutral forms of amines or other organic bases. See how Hamilton used PRP-C18 to separate six basic drug compounds.

A method for determining 16 PAHs in soil matrices using the Extreva Ase system, the Trace 1310 Gas Chromatograph, and the ISQ 7000 single quadrupole mass spectrometer.

This application note demonstrates a quick temperature ramp technique to improve the focusing of VOCs without using a secondary focusing trap.

Method for the determination of 16 PAHs in soil matrices using the EXTREVA ASE system and TRACE 1310 Gas Chromatograph and ISQ 7000 Single Quadrupole Mass Spectrometer

When detecting and analyzing PFAS, the greatest hurdles lie in the various matrices in which PFAS are found. Custom methods and extensive expertise help to solve these issues.

When detecting and analyzing PFAS, the greatest hurdles lie in the various matrices in which PFAS are found. Custom methods and extensive expertise help to solve these issues.

Learn how the non-targeted analysis of total fluorine can be done using Metrohm combustion ion chromatography.

Although the majority of benzodiazepines metabolize to a single compound, oxazepam, other metabolites can be detected by liquid chromatography.

In this study, a generic, 5-min linear gradient was used to separate six basic drug compounds on a short (50 mm) PRP-C18 column.

The Raffinose Family of Oligosaccharides (RFO) is comprised of low molecular weight non-reducing sugars. Analysis of these compounds is not easily done unless using HC-75.

Paclitaxel originates from the Pacific Yew tree. The isolation of paclitaxel from its major impurities is shown with the use of Hamilton’s PRP-1 (5 µm) HPLC column.

The fast simple method developed by Hamilton Company using the PRP-C18 column allows for simple, efficient identification of the whole vitamin series (K2, K3, and K4).

A Hamilton PRP-C18 (5 μm) HPLC column was used for purification of three oligonucleotides. Analysis of a 21-mer, 22-mer, and 23-mer of similar structure was evaluated.

The new Ascentis® Express PFAS HPLC and delay columns allow the highly efficient separation of 33 PFAS compounds in 5 minutes with reduced background contamination.

The presented methods are suitable for the quantification of THC and THCA (and other cannabinoids) in Cannabis sativa and to check THC-free cannabis for compliance.

This application note introduces a simple targeted extraction method for the analysis of nine nitazene compounds from urine and blood using the Clean Screen® DAU column.