Application Notes: General

Protein analysis plays a large role in the production of foods, pet foods, and even pharmaceutical medicines. But first, the amino acids in the protein must be broken down.

Peptide therapeutics are held to high regulatory standards. Discover Prep was used to hydrolyze the amino acids of a peptide in only 15 minutes, instead of 24 hours.

In this study, SPME Arrow sample preparation was tested for the analysis of furan and alkylfurans in baby formula and coffee samples.

Classical protocol of amino acid hydrolysis needs up to 24 h of reaction time. Using the Discover Prep, the same level of acid and base hydrolysis was achieved in minutes.

This application note describes a 2D-LC workflow for Protein A purification of mAbs, followed by online reduction and MS analysis of mAb subunits.

The determination of boiling range distribution of middle distillates and lubricating base oils by GC, with initial IBP of 100°C and FBP of below 750°C.

A separation of parabens is performed on a HALO 90 Å LPH-C18 column under low pH (pH 1) and high temperature conditions compared to a standard C18 SPP column.

A low pH compatible, 90 Å, superficially porous particle C18 phase is introduced as an addition to the chromatographer’s toolbox.

The natural products of the cannabis plant can number up to 100, but the scientific community is concerned with a smaller portion of around 10 to 20 compounds.

A HALO® LPH-C18 column is used to separate a mixture of 18 cannabinoids, showing fast results and high resolution within critical pairs.

SEC-MALS quantifies biophysical attributes of mRNA, including molar mass, percent aggregates, Rg, and Rh, and how they are affected by formulation and storage.

This app note outlines a highly efficient method for the simultaneous analysis of free and sulfated steroids from urine, plasma, and blood utilizing SPE and LC-MS/MS.

In this study, SPME Arrow sample preparation was tested for the analysis of furan and alkylfurans in baby formula and coffee samples.

Learn the importance of light scattering detection to determine the true molecular weight distribution of a poly(glutamic acid)-based copolymer for drug-delivery.

FAME and cis/trans FAME composition of three omega-3 supplements have been analyzed using two diferent columns, a 100% polyethylene glycol and a 100% biscyanopropyl.

Dioxins refer to polychlorinated dibenzo-p-dioxins and related compounds polychlorinated dibenzofurans. These two groups of compounds are among the most toxic chemicals.

GC-TQMS of pesticides is a routine application. The SCION 8900 TQMS with the 8500 GC can perform rapid multiplex screening of pesticides without losing sensitivity.

Crude oils consist of hundreds of hydrocarbon compounds in which the boiling point distribution of these crude oils is an important parameter in the petroleum industry.

This application note describes the automation of the isolation of 10 perfluorinated compounds (PFCs) from tap water prior to their analysis by LC–MS.

The fast identification of tocopherols is important for various applications including free radical scavenging for human health and food stuff preservation.

Go ahead, take the stress out of your LC method transfer journey with our free master guide. Features a compilation of proven techniques to help you succeed.

Learn how to transfer your LC methods the right way. A short case study with helpful guidance on how to transfer compendial methods, without needing revalidation.