Application Notes: General

ProPac 3R SAX columns will provide high resolution, robust performance and unrivalled lot-to-lot reproducibility needed for these applications.

Thermo Scientific ProPac 3R SCX columns provide excellent separation of mAb and associated charge variants using a salt gradient to give high-resolution, robust performance and excellent reproducibility

Thermo Scientific ProPac 3R SCX columns, combined with Thermo Scientific CX-1 pH gradient buffers, provide fast, reproducible, and ultra-high resolution for monoclonal antibodies and associated charge variants.

Nine structurally diverse, strongly basic drug compounds are resolved in less than 2 minutes using a high pH mobile phase and a fast acetonitrile gradient.

Chemically resistant resin bed allows for a wide base of mobile phase choices with excellent anion separation

This focuses on the identification of polyphenolic catechin compounds for health and industrial quantification and quality control of tea products.

The isolation of the diterpenoid, paclitaxel, from its major impurities is shown with the use of Hamilton’s PRP-1 (5 µm) HPLC column.

A reversed-phase HPLC method was developed for separation of five steroid hormones with partition coefficients ranging from 1.47 (cortisone) to 4.5 (pregnenolone).

In this study, a generic, 5-min linear gradient was used to separate six basic drug compounds on a short (50 mm) PRP-C18 column.

The identification benzodiazepine metabolites can be highly valuable in detecting abuse. Metabolites of oxazepam are found containing both hydroxyl and glucuronides.

This application note describes how Dow AgroSciences created efficiency in method development by incorporating method development software into their best practices.

Outlines an extraction procedure and an optional fluorenylmethyloxycarbonyl chloride derivatization step to allow for the analysis of glyphosate on a C18 column.

Improved and universal subunits LC–MS analysis of multiple classes of monoclonal antibodies using in-line electrochemical reduction  

Daicel Chiral Technologies' unique HPLC and SFC chiral stationary phases are capable of separating the most challenging compounds, like the atropisomers of Sotorasib.

Smart-ramped pyrolysis-GC–MS analysis of forensic samples such as paint, adhesive tape, and mascara gives maximum info in a single run without method development.

Smart-ramped pyrolysis-GC–MS analysis of nylon material in consumer products, food packaging, and clothing generates info in one run without method development.

Smart-ramped pyrolysis-GC–MS analysis of (meth)acrylates in consumer products, caulk, and nail hardener gives maximum info in a single run without method development.

Solvent-free extraction by passive sampling using TF-SPME and HSSE, and by active pumped sampling onto sorbent tubes, are compared for TD-GC–MS analysis of volatiles.

Olfactory detection of sensory-active compounds guides GC–MS analysis for efficient flavour assessment of foodstuffs and their plant-based replacement products.

Solvent-free extraction and analyte concentration using TF-SPME and SBSE are optimized for TD-GC–MS determination of flavour compounds in hard seltzer beverages.

This study demonstrates the use of pyrolysis-(GC¬–)MS to generate simulated TGA-MS data for polymers. The mode of operation is also referred to as evolved gas analysis.

Smart-ramped pyrolysis-GC¬–MS analysis of microplastics in water filtration residue gives maximum info in one run. Examples are runoff, grey-, pond-, and bottled water.

A micro-scale chamber method performs DNPH derivatization and Tenax TA sorption for analysis of formaldehyde and carbonyl compounds by LC–UV, and VOCs by GC–MS.

This application note shows that a single column to be used for the analysis of a wide range of molecular sizes, from intact proteins and monoclonal antibodies to digested peptides.

This application note describes the benefits of automated gravimetric liquid dispensing compared to traditional manual stock solution preparation in a volumetric flask.

This application note examines a group of UHPLC columns and their analytical conditions using synthesized miRNA samples.