Application Notes: General

This application note presents a side-by-side comparison of the AdvanceBio and GlycoWorks kits for the preparation and analysis of released N-glycans.

Tyrosine Kinase Inhibitors (TKIs) are a class of small molecule drugs used to alter cell growth pathways for the treatment of cancer. Specifically, Sunitinib, a TKI on the market, is available to treat a variety of cancers including pancreatic cancer. Here we create a method to support the therapeutic drug monitoring of Sunitinib and its active metabolite.

Four phosphopeptides are analyzed using a bioinert coated YMC-Accura Triart C18 column, providing high intensities, recoveries, and great peak shapes.

Detecting over 120 pollutants including pesticides, PAHs, PCBs, phthalates and adipates, this method can prove useful in environmental crises involving water pollution.

Analysis of trace per- and polyfluorinated organic vapours in air using cryogen-free thermal desorption and gas chromatography–mass spectrometry

This application note examines a group of UHPLC columns and their analytical conditions using synthesized miRNA samples.

This application note describes online monitoring of a chemical reaction that produces a byproduct, and presents a fully automated sampling workflow.

This application note shows that a single column to be used for the analysis of a wide range of molecular sizes, from intact proteins and monoclonal antibodies to digested peptides.

Here, we introduce HPLC columns with wider pores designed to analyze the characterization of the first-dimensional structure of peptides in reverse phase condition.

Application of C18, 1.6 µm UHPLC columns in the analysis of insulin with strong and weak ion pairing agents to see how they increase the height of the insulin peak.

Find out how the Alliance iS HPLC System makes method migration more straightforward with usability features that limit analyst error and improve system reliability.

Pharma QC labs face growing demands to do more with less. With capabilities developed specifically for the QC lab, the Alliance iS HPLC System will quickly become your favorite ally.

This application note introduces the usefulness of wide pore columns, targeting large macromolecules.

Learn how to generate quality data that meets the regulatory requirements of the U.S. Pharmacopeia Chapter <621> with the Alliance iS HPLC System.

This application note introduces application data obtained by using FlexFire SEC Columns that have adopted newly developed superior silica.

This application note covers high-resolution oligonucleotide analysis using a wide pore (WP) C18 1.6 µm UHPLC column.

See how the Alliance iS HPLC System’s tool-free fittings and improved wash function can eliminate volumetric carryover and reduce adsorptive carryover, respectively.

This app note demonstrates the excellent performance of mediterranea sea18 for MMA, MCA, and HCyr quantification by LC–MS for second tier tests in newborn screening.

Hydrogen is the perfect molecule for gas chromatography, especially for the replacement of the expensive Helium.

Peptide analysis in the GI tract shows links to endocrine, cardiac, and nervous systems. See how Hamilton Company isolates GPCR binding peptides with its PRP-3 column.

To address the Helium shortage GC laboratories have begun looking at possible replacement gases and new approaches to help obtain the carrier gases needed to continue their work. One of the most promising options is using the use of gas generators to provide a steady supply of hydrogen gas as a replacement for helium. Although some concerns—and some myths—persist about using hydrogen, it offers multiple benefits and advantages over helium, notably particularly when a gas generator replaces high-pressure gas cylinders.

Helium is running out, the worldwide demand is exceeding current production levels. Learn how Hydrogen could be your perfect replacement for Helium.

Find out how the Alliance iS HPLC System makes method migration more straightforward with usability features that limit analyst error and improve system reliability.

See how the Alliance iS HPLC System’s tool-free fittings and improved wash function can eliminate volumetric carryover and reduce adsorptive carryover, respectively.

Beverage producers need to ensure the purity of carbon dioxide (CO₂) gas used to manufacture their products for consistent quality. They need a system that can both determine absolute purity and identify trace impurities at low levels. Industry-standard UV fluorescence analyzers are prone to maintenance issues causing extended downtime. This note demonstrates how a fully integrated solution – the Thermo Scientific™ MAX-Bev™ CO₂ Purity Monitoring System – provides the robust, reliable solution that beverage producers need. The system is engineered for demanding process environments and allows users to measure absolute purity along with trace impurities in CO₂ down to single-digit parts-per-billion (ppb).