March 2022 | LCGC North America

But Why Doesn’t It Get Better? Kinetic Plots for Liquid Chromatography, Part III: Pulling It All Together

March 01, 2022

Column: LC Troubleshooting

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With kinetic plots, you can make better-informed column choices. Here’s how.

Quick Polar Pesticides (QuPPe): Learning from and Expanding on the Work of Others

March 01, 2022

Column: Sample Prep Perspectives

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The QuPPe method expands on QuEChERS to tackle highly polar compounds.

Split/Splitless Inlets in Gas Chromatography: What’s Up with All Those Different Glass Inlet Liners?

March 01, 2022

Column: GC Connections

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The glass inlet liner is one of the most important, yet least understood and most often ignored, components of a gas chromatographic experiment.

Charge Detection Mass Spectrometry: What’s the “Big” Deal?

March 01, 2022

Column: Focus on Biopharmaceutical Analysis

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Charge detection mass spectrometry (CDMS) is a useful tool to characterize larger, more complex biopharmaceuticals like bispecific antibodies and ADCs.

Critical Evaluation of Chromatography Methods: Essential Detective Skills

March 01, 2022

Columns

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A little preparation eases the challenges of new methods—and increases the fun.

Enter the Matrix: Improving the Interpretation of Separations Data Using Chemometrics in Analytical Investigations

March 01, 2022

Featured Article

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Examples from food science illustrate the usefulness of chemometrics techniques like pattern recognition, regression, and classification.

A Suitable Therapeutic Drug Monitoring Method for Amoxicillin in Plasma by High Performance Liquid Chromatography–UV (HPLC–UV) in Neonates

March 01, 2022

Peer-Reviewed Article

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This simple, rapid, and accurate HPLC-UV method can facilitate routine therapeutic drug monitoring in neonates.