Advances in (U)HPLC | LCGC Supplements

Evaluation of Kinetic Performance of Reversed-Phase Columns for Protein Separations by Gradient Kinetic Plots

May 02, 2023

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This article compares the performance of wide-pore silica monolithic, sub-2µm FPP, and SPP columns, addresses the question of whether 1000 Å or 400 Å SPP columns are more suitable for reversed-phase LC-type protein separations, and presents a kinetic performance comparison of different columns.

Micro-Pillar Array Column Separations for Proteomics of Liver Organoids

May 02, 2023

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A micro-pillar array format for mapping the proteome of human stem cell-derived liver organoids using timsTOF–MS is presented.

Evaluation of PGC Stationary Phases Under High-Temperature LC Conditions for the Analysis of Parabens in Food Samples

May 02, 2023

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This article highlights an advantage of porous graphitic carbon columns, that is their resistance at high temperatures, for the analysis of parabens in foodstuffs.

From the Guest Editor: Advances in (U)HPLC

May 02, 2023

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An introduction from guest editor, Gert Desmet from Vrije Universiteit Brussel, Belgium

When van Deemter Goes Upside Down in Chiral Chromatography

May 02, 2023

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The occurrence of convex-upward van Deemter curves is rare but not unusual in chiral liquid chromatography. In this work, this behaviour, experimentally observed for the more retained enantiomer of a chiral sulfoxide on a polysaccharide-based CSP, is explained.

Exploring Biopharmaceutical Analysis with Compact Capillary Liquid Chromatography Instrumentation

May 01, 2023

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A recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.