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Subcritical water chromatography (SBWC) is seen as an increasingly enticing prospect to replace high performance liquid chromatography (HPLC) in industrial settings because of its low costs and environmental impact. Yu Yang of East Carolina University, in Greenville, North Carolina, USA, has conducted research into this process for two decades. He recently spoke to Lewis Botcherby of The Column about his work, why companies should consider SBWC, and its role in pharmaceutical analysis.

Trajan Scientific and Medical (Melbourne, Australia) has announced the acquisition of LEAP Technologies Inc. (Carrboro, North Carolina, USA).

An Advanced Grant worth 2.5 million Euros has been awarded to Peter Schoenmakers of the University of Amsterdam (UvA) to develop new high-performance separation technology.

This year, LCGC is pleased to honour Debby Mangelings as the winner of the 2016 Emerging Leader in Chromatography Award. Mangelings received her award on Monday 7 March during an oral symposium at Pittcon 2016 in Atlanta, Georgia, USA.

Researchers from Heilongjiang University of Chinese Medicine, China, have used ultrahigh-performance liquid chromatography coupled to mass spectrometry and metabolomics to investigate the metabolic networks of Alzheimer’s disease, identifying potential biomarkers and biochemical mechanisms.

The literature on reversed-phase liquid chromatography (LC) of proteins is reasonably well developed, but not taught in the college classroom much. Kevin Schug therefore wants to focus on a stoichiometric displacement model for reversed-phase LC of proteins and why it is particularly insightful from a practical perspective.

This is the first of a four-part series of articles exploring current topics in separation science that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June.

The 40th International Symposium in Capillary Chromatography (ISCC) and 13th GC×GC Symposium will be held at the Palazzo dei Congressi, in Riva del Garda, Italy, from 29 May–3 June 2016.

Click the title above to open The Column April 25, 2016 North American issue, Volume 12, Number 7, in an interactive PDF format.

Analytica 2016 Tuesday Morning Sessions

Analytica 2016 Tuesday Afternoon Sessions

Analytica 2016 Wednesday Morning Sessions

Analytica 2016 Wednesday Afternoon Sessions

Magnetic nanoparticles (m-NPs) are becoming important in analytical chemistry as sorbents in dispersive solid-phase extraction (d-SPE) because they simplify the extraction process and save time as a result of their isolation from the sample matrix by an external magnetic field. Many synthetic processes have been developed to fabricate these nanomaterials and an additional coating step is usually included at the end of the synthesis to improve their stability and to avoid the formation of agglomerates. A wide variety of coatings have been used for this purpose to improve selectivity. This manuscript provides an overview of the different synthesis methods, coatings, and applications of m-NPs as sorbents in d-SPE.

Recent progress in supercritical fluid chromatography (SFC) instrumentation has led to renewed interest in the technique as a powerful tool for chiral and achiral separations of pharmaceutical molecules, for both analytical and preparative purposes. The “green” aspect of the technique and low running costs make SFC technology particularly attractive for preparative chromatography because it considerably reduces the consumption of organic solvents. These factors led to a revised strategy for purification and to a general interest in evaluating possible extensions for the application of packed SFC (pSFC). The results of this extensive evaluation have led to the establishment of SFC platforms for preparative achiral purifications as a standard practice, alongside its use for preparative chiral separations.

What should you do if your retention times drop from one injection to the next? A systematic approach to troubleshooting can help to quickly identify the problem source.

The 40th International Symposium in Capillary Chromatography (ISCC) and 13th GC×GC Symposium will be held at the Palazzo dei Congressi, in Riva del Garda, Italy, from 29 May–3 June 2016.

Our annual review of new liquid chromatography (LC) columns and accessories introduced at Pittcon and throughout the previous year.

Analytica 2016 Thursday Morning Sessions

Analytica 2016 Thursday Afternoon Sessions

A team of researchers from the State Laboratory of Chemo/Biosensing and Chemometrics in China has developed a novel high performance liquid chromatography-diode array detection (HPLC-DAD) method for the identification of six synthetic colours in five beverages.

Jean-Luc Veuthey and Alexandre Grand-Guillaume-Perrenoud reveal the latest developments in supercritical fluid chromatography (SFC) that are bringing the technique back to the limelight.

I often get asked about the other important aspects of “screening” in HPLC, which include the mobile phase composition, gradient parameters and flow rate – so that’s the theme of this installment.

Experienced gel permeation chromatography/size-exclusion chromatography (GPC/SEC) users know that equilibration of the columns takes much longer than the time needed by the pump to produce a constant flow. An analysis in this phase would clearly yield different results from those achieved after complete equilibration of GPC/SEC columns. Furthermore, false but constant flow rates affect the molar masses derived from a GPC/SEC calibration curve. An internal flow marker can help to increase reproducibility and accuracy of GPC/SEC results.

A glimpse of what can be expected at Analytica 2016.

Trajan Scientific (Melbourne, Australia), which develops medical devices as well as analytical systems such as gas and liquid chromatography columns and sample preparation systems, has acquired the business of LEAP Technologies (Carrboro, North Carolina).

A team of researchers has developed a high‑throughput analysis method for 192 diverse pesticides and 51 environmental contaminants in cattle, swine, and poultry meats. The team used a combination of low-pressure gas chromatography coupled to tandem mass spectrometry (LP)GC–MS–MS and ultrahigh-pressure liquid chromatography coupled to tandem MS in the analysis.

Researchers from the Joint Research Centre of the European Commission have published a case study detailing the characterization of new psychoactive substances using gas chromatography–mass spectrometry, nuclear magnetic resonance, high‑resolution tandem mass-spectrometry, and Raman spectroscopy.