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A look at the inspirations and future plans of a leading young scientist.

Detecting impurities in any chemical reaction is becoming increasingly important to detect those present at low levels (for example, 0.5%).

Click the title above to open the LCGC Europe May 2016 regular issue, Vol 29, No 5, in an interactive PDF format.

Click the title above to open the LCGC North America May 2016 regular issue, Vol 34 No 5, in an interactive PDF format.

Click the title above to open the May 2016 issue of Current Trends in Mass Spectrometry, Volume 14, Number 2, in an interactive PDF format.

Ted Szczerba, Technical Director of Chromatography and SFC Separations at Regis Technologies, overviews incorporating Supercritical Fluid Chromatography (SFC) into his separations lab. With over 30 years experience working with chiral compounds and over 10 years running SFC, he assesses the value of the technique versus the drawbacks of what is available in the field today. Learn about a typical screening day and this industry veteran's advice on what is needed for an effective separations process.

Your current contract laboratory and instrument provider may be familiar and comfortable, but, maintaining the status quo doesn’t lead to greater rewards. In fact, it often involves putting up with less-than-desired results. Join us in this executive summary to hear how Ajinomoto Althea develops unsurpassed solutions for biopharma companies, and how a team at Thermo Fisher Scientific has challenged the status quo to deliver uncompromised UHPLC.

Subcritical water chromatography (SBWC) is seen as an increasingly enticing prospect to replace high performance liquid chromatography (HPLC) in industrial settings because of its low costs and environmental impact. Yu Yang of East Carolina University, in Greenville, North Carolina, USA, has conducted research into this process for two decades. He recently spoke to Lewis Botcherby of The Column about his work, why companies should consider SBWC, and its role in pharmaceutical analysis.

Trajan Scientific and Medical (Melbourne, Australia) has announced the acquisition of LEAP Technologies Inc. (Carrboro, North Carolina, USA).

An Advanced Grant worth 2.5 million Euros has been awarded to Peter Schoenmakers of the University of Amsterdam (UvA) to develop new high-performance separation technology.

This year, LCGC is pleased to honour Debby Mangelings as the winner of the 2016 Emerging Leader in Chromatography Award. Mangelings received her award on Monday 7 March during an oral symposium at Pittcon 2016 in Atlanta, Georgia, USA.

Researchers from Heilongjiang University of Chinese Medicine, China, have used ultrahigh-performance liquid chromatography coupled to mass spectrometry and metabolomics to investigate the metabolic networks of Alzheimer’s disease, identifying potential biomarkers and biochemical mechanisms.

The literature on reversed-phase liquid chromatography (LC) of proteins is reasonably well developed, but not taught in the college classroom much. Kevin Schug therefore wants to focus on a stoichiometric displacement model for reversed-phase LC of proteins and why it is particularly insightful from a practical perspective.

This is the first of a four-part series of articles exploring current topics in separation science that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June.

The 40th International Symposium in Capillary Chromatography (ISCC) and 13th GC×GC Symposium will be held at the Palazzo dei Congressi, in Riva del Garda, Italy, from 29 May–3 June 2016.

Click the title above to open The Column April 25, 2016 North American issue, Volume 12, Number 7, in an interactive PDF format.

Click the title above to open The Column April 24, 2016 Europe & Asia issue, Volume 12, Number 7, in an interactive PDF format.

Analytica 2016 Tuesday Morning Sessions

Analytica 2016 Tuesday Afternoon Sessions

Analytica 2016 Wednesday Morning Sessions

Analytica 2016 Wednesday Afternoon Sessions

Magnetic nanoparticles (m-NPs) are becoming important in analytical chemistry as sorbents in dispersive solid-phase extraction (d-SPE) because they simplify the extraction process and save time as a result of their isolation from the sample matrix by an external magnetic field. Many synthetic processes have been developed to fabricate these nanomaterials and an additional coating step is usually included at the end of the synthesis to improve their stability and to avoid the formation of agglomerates. A wide variety of coatings have been used for this purpose to improve selectivity. This manuscript provides an overview of the different synthesis methods, coatings, and applications of m-NPs as sorbents in d-SPE.

Recent progress in supercritical fluid chromatography (SFC) instrumentation has led to renewed interest in the technique as a powerful tool for chiral and achiral separations of pharmaceutical molecules, for both analytical and preparative purposes. The “green” aspect of the technique and low running costs make SFC technology particularly attractive for preparative chromatography because it considerably reduces the consumption of organic solvents. These factors led to a revised strategy for purification and to a general interest in evaluating possible extensions for the application of packed SFC (pSFC). The results of this extensive evaluation have led to the establishment of SFC platforms for preparative achiral purifications as a standard practice, alongside its use for preparative chiral separations.

What should you do if your retention times drop from one injection to the next? A systematic approach to troubleshooting can help to quickly identify the problem source.

The 40th International Symposium in Capillary Chromatography (ISCC) and 13th GC×GC Symposium will be held at the Palazzo dei Congressi, in Riva del Garda, Italy, from 29 May–3 June 2016.

Our annual review of new liquid chromatography (LC) columns and accessories introduced at Pittcon and throughout the previous year.