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Keith Bartle, Emeritus Professor of Physical Chemistry and Visiting Professor in the Energy Centre of the University of Leeds, UK, has been a creative catalyst in a wide range of chromatographic collaborations stretching from the analysis of methane in air to printing inks. He spoke to Caroline West from the University of Orléans, in Orléans, France, about his career in chromatography and his proudest scientific achievements in separation science, including his research in supercritical fluid chromatography (SFC), gas chromatography (GC), and “the unified chromatograph”.

A reader’s problem of a method that fails the repeatability requirement of the system suitability test serves as an example of how to approach liquid chromatography (LC) method troubleshooting.

The 23rd International Symposium on Separation Sciences (ISSS 2017) will be held from 19–22 September 2017 at the Vienna University of Technology, located in the heart of the historic Vienna city centre in Austria.

Interest in chromatography using hydrophilic interaction liquid chromatography (HILIC) has continued to build in recent years. Adoption of the technique has been slowed by experiences of poor reproducibility. In particular, reequilibration times in HILIC have been reported as being exceptionally long as compared to reversed-phase chromatography. In this study, reequilibration times in HILIC for both aqueous–organic gradients and buffer gradients are systematically explored. The results not only promise to improve method development practices, but also provide insight into HILIC retention mechanisms across mechanistically differing polar stationary phases.

Opiate abuse is drastically on the rise in the United States. In addition to traditional naturally occurring opiate compounds, forensic toxicologists also need to be able to rapidly identify synthetic opioid-like drugs. A rapid, three-step solid-phase extraction (SPE) procedure for the identification and quantification of fentanyl and its major urinary metabolite norfentanyl, in addition to four “designer” compounds, U-47700, W-18, W-15, and furanyl fentanyl, is presented here. As a result of the rapid use and abuse of fentanyl in medical and recreational settings, respectively, it is important to develop a method that can accurately extract this Schedule II drug from any other novel compounds that may be present.

Researchers investigating paper mill effluents and their impact on surface waters in Slovenia have identified endocrine disrupting compounds (EDCs) and their mutagenic and genotoxic properties using gas chromatography–mass spectrometry (GC–MS).

The vast majority of macromolecules exhibit a molar mass distribution that is often described by the polydispersity index (PDI). This Tips & Tricks instalment offers practical advice to consider when analyzing macromolecules using liquid chromatography (LC).

The degree and strength of self-association are critical quality attributes for insulin and its analogues. In this article we present the label-free determination of these quantities using composition-gradient multi-angle light scattering (CG-MALS), enabling the formulation of engineered insulin optimized for stability and efficacy.

A preview of the 8th International Symposium on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM-8).

Selected highlights of innovative chromatography products.

This article looks at the practical benefits of microflow liquid chromatography–mass spectrometry (LC–MS) in bioanalysis applications.

Click the title above to open the LCGC Europe December 2016 regular issue, Vol 29, No 12, in an interactive PDF format.

Click the title above to open the LCGC North America December 2016 regular issue, Vol 34 No 12, in an interactive PDF format.

Click the title above to open The Column November 23, 2016 Europe & Asia issue, Volume 12, Number 21, in an interactive PDF format.

Click the title above to open The Column November 23, 2016 North American issue, Volume 12, Number 21, in an interactive PDF format.

This article looks at the practical benefits of microflow liquid chromatography–mass spectrometry (LC–MS) in bioanalysis applications.

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Research on nasal spray formulation has yielded an improved in vitro analytical test method utilizing thin layer chromatography (TLC). The research used simulated nasal mucus with varying properties and a TLC apparatus to assess the dripping behaviour of nasal formulations to improve the nasal spray development process.Nasal Spray Evaluation Using Thin Layer Chromatography

Rudolf Krska of the University of Natural Resources and Life Sciences (BOKU), in Vienna, Austria, has been awarded the biennial B.R.A.I.N award at the Biomin scientific conference held in Vancouver, Canada.