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Identifying Post-Translational Modifications in Monoclonal Antibodies Analyzing post-translational modifications-such as glycosylation, oxidation, and deamidation-at different levels can reveal different types of information.

Liposomes are often used as nanocarriers to encapsulate in their cores hydrophobic or highly toxic drugs, and deliver these drugs safely to target tissue. During drug nanocarrier research and development as well as production quality control, it is of great importance to monitor liposome size distributions accurately while also verifying drug encapsulation. FFF-MALS-DLS, consisting of field-flow fractionation (FFF) combined with multi-angle light scattering (MALS) and dynamic light scattering (DLS), is a powerful tool for characterizing the size, concentration, and structure of large nanoparticle ensembles.

This application note describes a combined approach of analytical method development and method transfer by direct emulation of different target HPLC systems.

Modern therapeutic antibody formats, such as bispecific antibodies (bsAbs), are on the rise. Bispecific antibodies are artificial proteins that recognize two different epitopes and can simultaneously bind to two different types of antigen. They can be used to redirect T cells to tumour cells, block two different signalling pathways simultaneously, dually target different disease mediators, and deliver payloads to targeted sites.

The 15th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-15) will be held at Cardiff City Hall, Cardiff, United Kingdom, from 24–26 January 2018.

ChromSoc’s Advances in Gas Chromatography meeting will take place at The Heath Business and Technical Park, Runcorn, Cheshire, UK, on 18 October 2017.

Click the title above to open the LCGC Asia Pacific September 2018 regular issue, Vol 20, No 3, in an interactive PDF format.

Click the title above to open the LCGC Europe September 2017 regular issue, Vol 30, No 9, in an interactive PDF format.

As the fall semester starts, I begin my 13th year as a chemistry professor. Let me get right to the point-if you do not love this job, you will hate it!

A method to determine the quality of olive oil has been developed using a novel atmospheric pressure chemical ionization (APCI) source in combination with gas chromatography (GC) coupled to hybrid quadrupole time-of-flight mass spectrometry (QTOF-MS) and a metabolomics strategy.

VUV Analytics has announced Hans-Gerd Janssen and his laboratory at the University of Amsterdam, The Netherlands, as the recipient of their academic grant.

Gary J. Patti is the recipient of the 2017 Agilent Early Career Professor Award.

Researchers from the Université de Strasbourg, France, have developed a method to discover cocoa bean origin by analyzing chocolate polyphenols using high performance liquid chromatography–diode array detection–mass spectrometry.

This proof-of-principle study shows that dynamic headspace sampling with thermal desorption–gas chromatography–time‑of-flight mass spectrometry (TD–GC–TOF-MS) analysis can be used to investigate the complex aroma profiles released from flavoured cookies. Key flavour compounds in chocolate-chip, peanut, and orange-cream cookies are highlighted, and the effect of raising the headspace extraction temperature is examined.

A rapid and sensitive ultrahigh-pressure liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) method was developed to simultaneously determine six plant growth regulators in bean sprouts with a simple preparation. Analyte extraction from samples was effectively performed using liquid–liquid extraction (LLE) by acetonitrile. Chromatographic separation was conducted on a C18 reversed-phase column with gradient elution. The analytes were detected by tandem quadrupole MS after negative electrospray ionization by multiple reaction monitoring. The developed method was validated by testing method specificity, matrix effect, sensitivity, linearity, accuracy, and precision.

A preview of RAFA 2017, which will be held 7–10 November 2017 in Prague, Czech Republic.

Click the title above to open The Column August 22, 2017 Europe & Asia issue, Volume 13, Number 12, in an interactive PDF format.

Click the title above to open The Column August 22, 2017 North American issue, Volume 13, Number 12, in an interactive PDF format.

Peak Scientific has celebrated 20 years since its foundation.

Ram Sasisekharan has received the 2017 Agilent Thought Leader Award in recognition of his contributions in the field of biologics characterization.

Thermo Fisher Scientific Inc. and SRI International have announced they will be collaborating to enhance small molecule research.

Researchers from ANSES have investigated the human health risks related to the consumption of foodstuffs produced on sites polluted by munitions from the First World War using GC–MS, HPLC–ICP-MS, and UHPLC–MS.

Combinations of detectors are often used in gel permeation chromatography/size-exclusion chromatography (GPC/SEC) to measure absolute molar masses or chemical compositions as a function of elution volume. Such multidetector setups require the correction of the delay volume between the detectors for correct data processing. This instalment of Tips & Tricks explains more.