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In 2009 I wrote an article on the emerging field “Bio Chromatography,” which for a small molecule analyst such as myself, perfectly described the situation. I realize that the separation of biomolecules had been happening for many years, but the expansion and development of protein based therapeutics from that point onwards has seen an avalanche of developments in instrumentation, sample preparation, and column technologies the like of which I have not seen in my 30 year career.

The recent introduction of high resolution, accurate mass (HRAM) OrbitrapTM technology coupled to GC brings a new level of performance and flexibility in full scan acquisition and more. Comparable sensitivity and selectivity of triple quadrupole GC-MS/MS, but with broad scope, and the capability for simultaneous targeted and non-targeted analysis of pesticides at low ng/g concentrations, in complex sample types. In this Q & A, Paul Silcock discusses the story so far, around the use of Orbitrap GC-MS for quantitative and qualitative multi-residue analysis of pesticides.

Gas chromatography (GC) is a powerful technique for environmental analysis. The articles in this new e-book look at both the technique and its application, providing essential information about GC fundamentals as well as an example of how the technique can be used in new ways in environmental analysis.

Compared to the magnitude of unconventional oil and gas development activity that has been performed by industry, the amount of research to assess its potential environmental impact has been miniscule. Can the process have a deleterious impact if not well managed? Can it be performed in a responsible manner?

This is the second in a four-part series of articles exploring topics that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June.

The 40th International Symposium on Capillary Chromatography (ISCC) and 13th GC×GC Symposium will be held at the Palazzo dei Congressi, in Riva del Garda, Italy, from 29 May–3 June 2016.

Spark Holland B.V.and Axel Semrau have announced an expansion of their existing distribution deal to include Switzerland and Austria.

Researchers from Colorado State University have demonstrated the viability of exploratory metabolomics and HILIC–MS in identifying biomarkers associated with dengue virus (DENV) infections, such as dengue fever, dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS).

In this Q&A, we will talk to Dr. Arthur Fitchett, Director of Sales Training at Thermo Fisher Scientific. We will discuss recent advances in ion chromatography technology, what they mean for different types of IC analyses, and how they can improve results in your laboratory.

Click the title above to open The Column May 06, 2016 Europe & Asia issue, Volume 12, Number 8, in an interactive PDF format.

Click the title above to open The Column May 06, 2016 North American issue, Volume 12, Number 8, in an interactive PDF format.

Using supercritical CO2

LCGC magazine is pleased to announce the addition of Deirdre Cabooter to the editorial advisory boards of LCGC North America and LCGC Europe.

This new e-book considers what functions and features should be available in an ideal chromatography data system (CDS) for use in a regulated analytical laboratory.

Click the title above to open the LCGC Europe May 2016 Recent Developments in LC Column Technology Supplement, Vol 29, No s5, in an interactive PDF format.

Whole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were carried out using volumetric absorptive microsampling (VAMS), a novel blood collection device that allows the sampling of a known blood volume independently from hematocrit. The composition of the extraction medium was optimized using an experimental design to get the most intense signal of hepcidin, considering different organic solvents and acidic additives.

A commentary on maintaining and growing technical competencies and the effort that is required.

The SFC conference tackled theory, economics, scale-up, and more.

A look at the inspirations and future plans of a leading young scientist.

Detecting impurities in any chemical reaction is becoming increasingly important to detect those present at low levels (for example, 0.5%).

Click the title above to open the LCGC Europe May 2016 regular issue, Vol 29, No 5, in an interactive PDF format.

Click the title above to open the LCGC North America May 2016 regular issue, Vol 34 No 5, in an interactive PDF format.

Click the title above to open the May 2016 issue of Current Trends in Mass Spectrometry, Volume 14, Number 2, in an interactive PDF format.

Ted Szczerba, Technical Director of Chromatography and SFC Separations at Regis Technologies, overviews incorporating Supercritical Fluid Chromatography (SFC) into his separations lab. With over 30 years experience working with chiral compounds and over 10 years running SFC, he assesses the value of the technique versus the drawbacks of what is available in the field today. Learn about a typical screening day and this industry veteran's advice on what is needed for an effective separations process.

Your current contract laboratory and instrument provider may be familiar and comfortable, but, maintaining the status quo doesn’t lead to greater rewards. In fact, it often involves putting up with less-than-desired results. Join us in this executive summary to hear how Ajinomoto Althea develops unsurpassed solutions for biopharma companies, and how a team at Thermo Fisher Scientific has challenged the status quo to deliver uncompromised UHPLC.