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Monoclonal antibody (mAb) treatment is among the most effective method of diagnosis and treatment of a broad range of diseases, including autoimmune disorders, cardiovascular diseases, infectious diseases, cancer, and inflammation. There is an extensive development pipeline for protein and mAb therapeutics, emphasizing the need for innovative and efficient analytical tools that result in faster analysis times. This article explores the use of supermacroporous particles for the analysis of mAbs.

To mark the Chromatographic Society’s 60th birthday, The Column interviewed the current President of The Chromatographic Society, Dr. Paul Ferguson, and Associate Principal Scientist for Separation Science at AstraZeneca, Macclesfield, UK, on the past, present, and future of the Chromatographic Society - and separation science.

Click the title above to open The Column May 24, 2016 Europe & Asia issue, Volume 12, Number 9, in an interactive PDF format.

Click the title above to open The Column May 24, 2016 North American issue, Volume 12, Number 9, in an interactive PDF format.

The increased use of electronic data and computerized systems has introduced new challenges to maintaining data integrity. With regulated companies under increased scrutiny by regulatory authorities, companies need to ensure they have a thorough understanding of their regulated systems and how to assess them for gaps. Waters will provide insight on the current focus for data integrity with specific examples of how to monitor Waters Empower data. We will also provide additional tools and services that can help prepare for internal and external audits.

Researchers from the USA have developed a simple and derivatization-free gas chromatography (GC) method for the quantitative analysis of oleic acid and related fatty acids.

Understanding how liquid chromatography pumps operate can help streamline solving pump problems.

Branching is one of the parameters chemists can adjust to produce polymer materials with optimized physical properties. Chromatography and advanced detection can help to characterize branched molecules. This instalment of Tips & Tricks explains more.

A brief introduction of the article presented in this supplement.

When selecting the optimum phase for SEC separations, several key column parameters must be considered carefully.

When selecting the optimum phase for SEC separations, several key column parameters must be considered carefully.

As clinical diagnostic assays move to LC–MS–MS, the emphasis has turned to emerging stationary phases that use alternative mechanisms of retention to separate the analyte–interference critical pairs.

Recent advances in chiral stationary phases have enabled higher efficiency and faster separations in studies of the differing enantiomeric activity of pesticides, their environmental transformation, and the degradation of pollutants in general.

In 2009 I wrote an article on the emerging field “Bio Chromatography,” which for a small molecule analyst such as myself, perfectly described the situation. I realize that the separation of biomolecules had been happening for many years, but the expansion and development of protein based therapeutics from that point onwards has seen an avalanche of developments in instrumentation, sample preparation, and column technologies the like of which I have not seen in my 30 year career.

The recent introduction of high resolution, accurate mass (HRAM) OrbitrapTM technology coupled to GC brings a new level of performance and flexibility in full scan acquisition and more. Comparable sensitivity and selectivity of triple quadrupole GC-MS/MS, but with broad scope, and the capability for simultaneous targeted and non-targeted analysis of pesticides at low ng/g concentrations, in complex sample types. In this Q & A, Paul Silcock discusses the story so far, around the use of Orbitrap GC-MS for quantitative and qualitative multi-residue analysis of pesticides.

Gas chromatography (GC) is a powerful technique for environmental analysis. The articles in this new e-book look at both the technique and its application, providing essential information about GC fundamentals as well as an example of how the technique can be used in new ways in environmental analysis.

Compared to the magnitude of unconventional oil and gas development activity that has been performed by industry, the amount of research to assess its potential environmental impact has been miniscule. Can the process have a deleterious impact if not well managed? Can it be performed in a responsible manner?

This is the second in a four-part series of articles exploring topics that will be addressed at the HPLC 2016 conference in San Francisco, USA, from 19–24 June.

The 40th International Symposium on Capillary Chromatography (ISCC) and 13th GC×GC Symposium will be held at the Palazzo dei Congressi, in Riva del Garda, Italy, from 29 May–3 June 2016.

Spark Holland B.V.and Axel Semrau have announced an expansion of their existing distribution deal to include Switzerland and Austria.

Researchers from Colorado State University have demonstrated the viability of exploratory metabolomics and HILIC–MS in identifying biomarkers associated with dengue virus (DENV) infections, such as dengue fever, dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS).

A team of researchers from the State Laboratory of Chemo/Biosensing and Chemometrics in China has developed a novel high performance liquid chromatography-diode array detection (HPLC–DAD) method for the identification of six synthetic colours in five beverages.

In this Q&A, we will talk to Dr. Arthur Fitchett, Director of Sales Training at Thermo Fisher Scientific. We will discuss recent advances in ion chromatography technology, what they mean for different types of IC analyses, and how they can improve results in your laboratory.

Click the title above to open The Column May 06, 2016 Europe & Asia issue, Volume 12, Number 8, in an interactive PDF format.

Click the title above to open The Column May 06, 2016 North American issue, Volume 12, Number 8, in an interactive PDF format.