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31st International Symposium on MicroScale Bioseparations

The numerous advantages of translating gradient chromatographic methods between the differing formats of LC have been explored and discussed. While translations in principle obey well defined chromatographic theories, the authors investigate a number of potential pitfalls that may result in poor translations as exhibited by selectivity differences, changes in efficiency, and hence failure to meet resolution system suitability criteria.

The transit of peaks through a gas chromatography (GC) column depends strongly on the thermal profile they encounter on the way. Gas chromatographers primarily rely on the classic hot?air?bath type of oven, but several alternatives are also in use. This instalment examines ovens for GC in several forms plus how oven thermals affect peak retention behaviour.

HIGHLIGHTS OF APPS FOR SEPARATION SCIENCE

Redox reactions are integral parts of many cellular processes. They are therefore extensively studied in vitro and in vivo. Electrochemistry (EC) represents a purely instrumental approach to characterize direct and indirect effects of redox reactions on bioorganic molecules. This review highlights important trends and recent developments.

This instalment examines ovens for GC in several forms plus how oven thermals affect peak retention behaviour.

A stepwise process is described to help isolate and identify the cause of a method failure.

Event: 21st International Symposium on Separation Sceinces (21st ISSS 2015)

A guide to selecting the correct HPLC stationary phase.

Accurate steroid measurement is essential for the diagnosis of various disorders, for example in sexual differentiation or gonadal function.

Pain management LC analyses can be difficult to optimize because of the limited selectivity of C18 and phenyl-hexyl phases.

Supercritical fluid chromatography (SFC) has been used by scientists in laboratories and manufacturing facilities for several decades.

Multi-angle light scattering (MALS) represents a uniquely powerful technique to determine the absolute molar masses and sizes of proteins in solution. MALS detectors cover a wide detection range of sizes and masses and enable the characterization of protein molecules as monomers, dimers, or higher order aggregates.

The physical properties and behaviour of polymers depends strongly on the properties of the polymer molecules themselves

There has been a significant resurgence in the development of antibody-drug conjugates (ADC) as target-directed therapeutic agents for cancer treatment.

Click the title above to open the LCGC Asia Pacific March 2015 regular issue, Vol 18, No 1, in an interactive PDF format.

Click the title above to open the LCGC Europe March 2015 regular issue, Vol 28, No 3, in an interactive PDF format.

Click the title above to open the LCGC North America March 2015 regular issue, Vol 33 No 3, in an interactive PDF format.

Click the title above to open the March 2015 issue of Current Trends in Mass Spectrometry, Volume 13, Number 1, in an interactive PDF format.

Incognito challenges commonly held views about consultants. Are you missing out on their valuable insight and know-how?

Detecting estrogens at trace concentrations in biological fluids is key to understanding their role in the induction - and treatment - of disease. Researchers from the University of Texas Arlington, USA, have developed a method using restricted access-media (RAM) that enables the detection of trace levels of estrogen's using LC–MS–MS without liquid–liquid extraction (LLE) or solid-phase extraction (SPE).

Click the title above to open The Column February 19, 2015 Europe & Asia issue, Volume 11, Number 3, in an interactive PDF format.

Click the title above to open The Column February 19, 2015 North American issue, Volume 11, Number 3, in an interactive PDF format.

Ultra-high performance liquid chromatography (UHPLC) enables fast, efficient separation of biomolec-ular samples. Compared to standard SEC, UHP-SEC provides improved resolution, higher throughput, less solvent and smaller sample consumption for analysis of precious biological samples.

In response to recent accusations levied by the New York State Attorney General’s office that herbal supplements sold by four major retailers contained little or no primary ingredient, the supplements industry is planning further testing of the affected products.

There are often times in my work when I need to 'mess about' with column dimensions and particle morphologies. For 'mess about' read improve or transfer.