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All sample preparation adds the potential for error to the analytical protocol, so choosing less-complicated techniques will help to reduce inherent error.

A highly sensitive and selective mercuric oxide–based reduction gas detector was successfully used for parts-per-billion level gas chromatography (GC) determination of ethylene in various matrices such as in the monitoring of fruit ripening, ambient air, and industrial solvents.

Here we describe a simple and robust high performance liquid chromatography–diode array detection (HPLC–DAD) method for the simultaneous determination of methotrexate (MTX) and sulphasalazine (SSZ) from plasma. MTX and SSZ are used in combination for the treatment of rheumatoid arthritis. Using two detector wavelengths, 304 nm for MTX and 358 nm for SSZ, we were able to selectively quantitate both analytes during the same chromatographic run. The method was validated using quality control samples for critical analytical performance criteria of recovery, reproducibility, selectivity, accuracy, and precision.

The LC/GC Checker app is designed to provide four approaches to check an LC or GC instrument's performance.

Click the title above to open the LCGC Europe May 2015 regular issue, Vol 28, No 5, in an interactive PDF format.

Click the title above to open the LCGC Europe May 2015 HPLC 2015 Show Guide Supplement, Vol 28, No s5, in an interactive PDF format.

Click the title above to open the LCGC North America May 2015 regular issue, Vol 33 No 5, in an interactive PDF format.

Click the title above to open the May 2015 issue of Current Trends in Mass Spectrometry, Volume 13, Number 2, in an interactive PDF format.

A new study presents a proteomics approach to investigate changes at the molecular scale that could control whether or not embyro implantation using IVF is successful.

Researchers from the University of Colorado have characterized flow?back water generated from fracking activities, using a combination of analytical techniques, to determine how best to treat wastewater so that it can be recycled.

Miniaturization has been one of the biggest trends in recent years. This article discusses the evolution and current applications of lab?on-a-chip technology in chromatography and explores the possibility of a new market for microfluidics in separation science.

Dr Vera Thoss from Bangor University (Bangor, Wales) spoke to Bethany Degg of The Column about her work investigating the chemistry of plants and the value of flash chromatography in this area of research.

Selected highlights of new products launched at Pittcon 2015.

Incognito offers his views on Pittcon 2015. What were your experiences like and did you have any arguments?

Since the founding of LCGC in 1983, we have made it our mission to serve the separation science community by publishing articles with a practical focus on improving chromatographic methods. Over the years, those articles have included many seminal works from leading analytical scientists who have made groundbreaking advances that have benefitted the entire community. This year, we are once again pleased to honour an outstanding chromatographer: Caroline West, the winner of the 2015 Emerging Leader in Chromatography Award. This year, we had the additional opportunity to honour West at Pittcon 2015 in an oral symposium as part of the Pittcon technical programme.

Click the title above to open The Column April 24, 2015 Europe & Asia issue, Volume 11, Number 7, in an interactive PDF format.

Click the title above to open The Column April 24, 2015 North American issue, Volume 11, Number 7, in an interactive PDF format.

A method was developed for the quantitation of benzodiazephines in biological samples using an Agilent 6430 Triple Quadrupole LC/MS system. The method displays excellent accuracy and precision using a weighted-quadratic calibration model.

Validation studies showed that the LC/MS/MS method provides reliable results for the analysis of benzodiazephines and the z-drugs zolpidem, zopiclone and zaleplon that meet acceptable criteria set for this application.