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Chromatographers often use the terms carrier-gas flow and velocity interchangeably when discussing column parameters. In liquid chromatography, the two terms scale together, but in gas chromatography they do not. This month’s “GC Connections” investigates the reasons for this non-intuitive behaviour and how it affects best practices for gas chromatographers.

The power of nontargeted metabolite profiling is illustrated in a study focused on the determination of molecular markers in malting barley that are predictive of desirable malting quality for brewing applications.

Click the title above to open the LCGC Asia Pacific March 2016 regular issue, Vol 19, No 1, in an interactive PDF format.

Click the title above to open the LCGC Europe March 2016 regular issue, Vol 29, No 3, in an interactive PDF format.

Click the title above to open the LCGC North America March 2016 regular issue, Vol 34 No 3, in an interactive PDF format.

Incognito offers some advice that is not to be taken lightly!

Aflatoxins are poisonous and carcinogenic chemicals that occur in nature in soil, hay, and grains. When contaminated food is processed, aflatoxins can enter the general food supply chain and can be dangerous for humans and animals. Time- and cost-efficient analytical methods can ensure food safety. Compared to conventional manual methods the use of “supercritical” CO2 for supercritical fluid extraction (SFE) as well as chromatographic separation (supercritical fluid chromatography [SFC]) of aflatoxins offers a more efficient process while reducing solvent consumption.

The powerful characteristics of gas chromatography (GC) with VUV (vacuum ultraviolet) detection for the analysis of saturated and unsaturated fatty acids are described.

The 9th International Symposium on Packed Column SFC (SFC 2015) was held in Philadelphia, Pennsylvania, USA, on 22–24 July 2015. Selected highlights of both the oral and poster SFC 2015 programmes are reviewed in this synopsis.

The Norwegian Institute of Public Health conducted a study into the drug use habits of nightclubbers and arrested criminals in Oslo, Norway. The study used UHPLC–MS–MS to analyze the drug-use profiles of nightclubbers and criminals arrested while under the influence of drugs to develop an understanding of drug use patterns in these groups.

Sciex has announced it is teaming up with the Children’s Medical Research Institute to help equip The Australian Cancer Research Foundation International Centre for the Proteome of Cancer facility with tools to advance its large‑scale proteomic profiling studies.

Research into honeybee venom is being performed to identify active proteins acting as allergens and toxins. Researchers combined LC–MALDI-TOF/TOF-MS–MS, LC–ESI-QTOF-MS–MS, and a combinatorial peptide ligand library enrichment method to detect 269 proteins.

The first meeting of The Chromatographic Society’s Diamond Jubilee celebration year will be held at the Institute of Engineering and Technology (IET) in Savoy Place, London, UK, on Tuesday 22 March 2016.

Click the title above to open The Column February 22, 2016 Europe & Asia issue, Volume 12, Number 3, in an interactive PDF format.

Click the title above to open The Column February 22 2016 North American issue, Volume 12, Number 3, in an interactive PDF format.

At a ceremony at the University of Copenhagen, Waters Corporation (Milford, Massachusetts) officially welcomed the University’s Forensic Chemistry Laboratory within the Department of Forensic Medicine into the Waters Centers of Innovation Program.

VUV Analytics (Cedar Park, Texas) is collaborating with Caltech Environmental Analysis Center (EAC) in Pasadena, California, in a closed-ended project that explores new application capabilities using VUV’s VGA-100 Vacuum Ultraviolet (VUV) detector.

A team of researchers from China and the USA has developed a liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) method for quantifying methylergonovine (ME), a semi-synthetic ergot alkaloid used for the treatment and prevention of postpartum haemorrhage (PPH), in human plasma.

If you don’t examine your LCMS data closely, you could be missing some of these effects, and those problems with your quantitative data will never be fixed.

Xiaoli Wang has been selected as the winner of the first 2016 Young Investigator Award from the Chinese American Chromatography Association (CACA).

Gel permeation/size-exclusion chromatography (GPC/SEC) is the standard method for separating samples by molecular size and determining molar mass distributions. However, GPC/SEC instruments can also be used to investigate porous materials and to learn more about pore size distributions, as a powerful alternative to nitrogen gas (N2) adsorption or mercury (Hg) intrusion porosimetry.

Contaminants in surface water and drinking water supplies arising from pharmaceutical and personal care product use as well as other compound sources pose a difficult challenge for analytical chemists. Thomas Letzel from the Technical University of Munich in Germany, spoke to The Column to discuss collaborative research taking place in Europe to address contaminants of emerging concern in water analysis.

Researchers from Imperial College London and the University of Aberdeen have identified disease markers for Human African Trypanosomiasis (HAT), commonly known as “sleeping sickness”. Using reversed-phase ultrahigh‑performance liquid chromatography coupled to mass spectrometry (UHPLC–MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy researchers found 53 discriminatory metabolite markers.

Sciex (Framingham, Massachusetts, USA) has announced a co‑marketing agreement with Pressure BioSciences, Inc. (South Easton, MA, USA), which aims to address the challenges arising in complex sample preparation.