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In recent years industry has been moving to columns with smaller and smaller inner diameters - moving from 4.6 mm and 3.0 mm i.d. columns to 2.1 mm, 1.0 mm, and even smaller. While small inner diameter columns have some clear advantages, they also bring challenges. Reduction of extracolumn volumes must be given greater consideration by both customers and manufacturers. This article focuses on the sources of band broadening within high performance liquid chromatography (HPLC) columns with an emphasis on eddy dispersion. The physical mechanisms of dispersion are discussed and a review of the current literature as it pertains to small inner diameter columns is presented.

Glycosylation of monoclonal antibody (mAb) therapeutics is widely recognized by the regulators and the industry as a critical quality attribute (CQA). Hence, it is necessary that glycosylation is measured and adequately controlled during production. This instalment reviews the various process parameters and raw material attributes that affect glycosylation, as well as the different analytical tools that are used for characterization, with greater emphasis on the chromatographic methods of analysis. Key recent advancements that have occurred in the past five years are also discussed briefly. While significant progress has been made in the monitoring of glycosylation, its real time control has yet to be demonstrated.

The 10th annual International Conference on Packed Column SFC (pcSFC) will be held 5–7 October 2016 at the Melia’ Vienna hotel in Vienna, Austria.

This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.

The Diablo 5000A RTGA-MS allows the process stream to be seen in real-time and provides quantitative data with reliable mass information. The result is visualization.

Click the title above to open the LCGC Europe July 2016 regular issue, Vol 29, No 7, in an interactive PDF format.

Click the title above to open the LCGC North America July 2016 regular issue, Vol 34 No 7, in an interactive PDF format.

Click the title above to open the July 2016 issue of Current Trends in Mass Spectrometry, Volume 14, Number 3, in an interactive PDF format.

The Chromatographic Society (ChromSoc) awarded Professor Peter Myers and Professor Iain Wilson the Martin Medal at HPLC 2016 in San Francisco, California, USA.

Emily Hilder and Derek Stevenson were awarded the Jubilee Medal by the Chromatographic Society at HPLC 2016 in San Francisco, California, USA.

Liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) alongside gas chromatography tandem mass spectrometry (GC–MS–MS) has been used to analyze 200 pesticides and pesticide metabolites in honeybees.

The 2016 Guiochon Fellowship was presented to Ying Ge at HPLC 2016 in San Francisco, California.

Lloyd Snyder was presented with the Uwe D. Neue Award in Separation Sciences at HPLC 2016 in San Francisco, California.

The session chair for this Wednesday afternoon session is Emily Hilder of the University of South Australia. The session will be held in the Golden Gate Ballroom C, floor B2 level, beginning at 1:30 p.m.

The Georges Guiochon Faculty Fellowship award will be presented at 7:00 pm on Monday, June 20. This year’s awardee is Dr. Ying Ge, who is an associate professor in the Department of Cell & Regenerative Biology and the Department of Chemistry at the University of Wisconsin-Madison.

This Tuesday morning session will be chaired by Mary Wirth of Purdue University and will be held in the Golden Gate Ballroom A on floor B2 level.

The presentation of the Martin and Jubilee Medals will take place Monday, June 20, at 7 pm at the Opening Plenary Session in the Golden Gate Ballroom, floor B2 level.

This Tuesday morning Parallel Session will be chaired by Paola Dugo of the University of Messina in Italy. It will take place in the Golden Gate Ballroom C, floor B2 level.

The Wednesday Parallel Session will be hosted by Jonathan Sweedler of the University of Illinois at Urbana-Champaign. It will take place in the Golden Gate Ballroom C, floor B2 level.

The 2016 Uwe D. Neue Award in Separation Science will be presented at 7:00 pm on Monday, June 20, after the Georges Guiochon Faculty Fellowship Award. This year’s awardee is Lloyd Snyder, who is retired from LC Resources. Synder is known not only for his many important contributions to an understanding of high performance liquid chromatography (HPLC), but also for his teaching, mentoring, and acclaimed publications.

This Tuesday morning session will be chaired by Milton Lee of Brigham Young University and will be held in the Golden Gate Ballroom A on floor B2 level. The session will begin at 11:15 am.

Today’s free tutorial sessions at the HPLC 2016 conference will cover a range of topics, from trends in sample preparation and the use of high pressures, to fundamentals of ultrahigh pressure liquid chromatography (UHPLC), to the role of small-molecule analysis in biopharma.

Today at the HPLC 2016 conference, four free tutorial sessions are offered to HPLC conferees. Today’s talks, from Dave Bell, Fred Regnier, Jonathan Sweedler, and Paul Haddad, cover hydrophobic interaction chromatography (HILIC), protein analysis, manuscript preparation, and HPLC method development.