LCGC North America
This application note demonstrates how LECO’s Pegasus® GC-HRT paired with its unique ChromaTOF-HRT® brand software, gives users the means to confidently identify “known unknowns” and “unknown unknowns” in swimming pool and hot tub water.
HPLC 2015 Monday Morning Sessions
HPLC 2015 Monday Afternoon Sessions
HPLC2015 Tuesday Afternoon Sessions
HPLC 2015 Wednesday Afternoon Sessions
HPLC 2015 Tuesday Morning Sessions
HPLC2015 Wednesday Morning Sessions
Once you have mastered the terminology and symbology the actual mathematics for the models and approaches used at the level which is useful to practicing analytical chemists is really very straightforward indeed.
LCGC Europe
The numerous advantages of translating gradient chromatographic methods between the differing formats of LC have been explored and discussed. While translations in principle obey well defined chromatographic theories, the authors investigate a number of potential pitfalls that may result in poor translations as exhibited by selectivity differences, changes in efficiency, and hence failure to meet resolution system suitability criteria.
LCGC Europe
The use of superficially porous particles (SPPs) in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent in recent years. Over the course of the past decade most major manufacturers have built column lines around the technology. At the recent Pittcon conference in New Orleans, Louisiana, USA, a large number of oral and poster presentations centred on the current research and advances using superficially porous particles. This instalment aims to provide some highlights of these recent trends.
LCGC North America
To characterize biopharmaceuticals, particularly monoclonal antibodies and antibody–drug conjugates (ADCs), you need a complete toolbox of powerful tools. You are probably familiar with LC–MS methods. But have you seen what light-scattering detection can do?
The Column
Using GPC/SEC for Excipient Characterization
The Column
A look to the upcoming symposium on the Recent Developments in Pharmaceutical Analysis (RDPA 2015), which will be held 28 June to 1 July 2015 in Perugia, Italy.
The Column
A novel microdestructive capillary electrophoresis (CE) method for the analysis of blue pen ink strokes has been published. The analysis of pen inks can be challenging because ink compositions are usually under patent, the samples are small, and inks can degrade over time.
The Column
Fracking activity in the northeast of the USA has rapidly increased over recent years, with over 8000 Marcellus wells drilled in the Marcellus Formation in Pennsylvania, USA, alone. Scientists in Pennsylvania investigating an isolated contamination incident have published data from their study, demonstrating the application of comprehensive 2D gas chromatography coupled with time-of‑flight mass spectrometry (GC×GC–TOF-MS) to investigate fracking contamination in a drinking water source.
The Column
Parabens are commonly used in cosmetics and personal care products to protect against microbial growth, but a new study suggests that manufacturers may also be using parabens in plastic teething products designed for infants. Scientists applied an effect-directed approach (to determine endocrine disrupting ability) to analyze teething products prior to chemical analysis using gas chromatography coupled to mass spectrometry (GC–MS). Of 10 products were tested, two were found to contain endocrine disrupting chemicals (EDCs).
LCGC Europe
Fast analysis of 14 banned carcinogenic aromatic amines using a Kinetex EVO C18 core-shell HPLC/UHPLC column with narrow peak widths along with excellent resolution between all compounds of interest.
LCGC North America
Fast analysis of 14 banned carcinogenic aromatic amines using a Kinetex EVO C18 core-shell HPLC/UHPLC column with narrow peak widths along with excellent resolution between all compounds of interest.
LCGC Europe
Better detection, separation, and ionization of cannabinoids by a high pH LC/MS method method that utilizes a high performance Kinetex EVO C18 column.
LCGC Europe
Quantitative method to accurately monitor paraben levels in food and other personal care products using Novum Simplified Liquid Extraction (SLE) products in conjunction with a Kinetex EVO C18 5 μm core-shell HPLC column.
LCGC North America
Better detection, separation, and ionization of cannabinoids by a high pH LC/MS method method that utilizes a high performance Kinetex EVO C18 column.
LCGC North America
Quantitative method to accurately monitor paraben levels in food and other personal care products using Novum Simplified Liquid Extraction (SLE) products in conjunction with a Kinetex EVO C18 5 μm core-shell HPLC column.
LCGC North America
Mass spectrometry (MS) is considered to be the gold standard in chemical detection due to the speed, selectivity, sensitivity, and versatility of the method. A miniaturized, linear ion trap, mass spectrometer can rapidly detect and unequivocally identify chemical targets that reduce the cost to analyze field samples and, more importantly, eliminate gaps in security because actionable information can be obtained on timescales that are relevant for security personnel
Sponsored Content
Ultra high resolution, accurate mass (UHRAM) mass spectrometry, based on the Thermo ScientificTM OrbitrapTM technology, is a powerful new approach to high throughput screening and quantitation in complex sample matrices. To learn more about how UHRAM is used in the Million Metabolome Project, an ambitious milestone for Exposome Research, LCGC talked with Dean Jones of Emory University.Click to view the associated whitepaper
LCGC Europe
A method is illustrated for the simultaneous analysis of nicotine, anabasine, and three of nicotine’s major metabolites (cotinine, nornicotine, and 3-hydroxycotinine) using the Kinetex 2.6 μm EVO C18 column.
LCGC Europe
Better identification and quantitation of low level peptides utilizing the powerful combination of unique selectivity and core-shell performance gains found with Kinetex EVO C18 core-shell columns.
LCGC North America
Better identification and quantitation of low level peptides utilizing the powerful combination of unique selectivity and core-shell performance gains found with Kinetex EVO C18 core-shell columns.
LCGC North America
A method is illustrated for the simultaneous analysis of nicotine, anabasine, and three of nicotine’s major metabolites (cotinine, nornicotine, and 3-hydroxycotinine) using the Kinetex 2.6 μm EVO C18 column.
LCGC North America
Achieve excellent peak shape and resolution between the broad spectrum antibiotic cefaclor and its degredants using the unique selectivity and high efficiency of a Kinetex EVO C18 core-shell.
LCGC Europe
Achieve excellent peak shape and resolution between the broad spectrum antibiotic cefaclor and its degredants using the unique selectivity and high efficiency of a Kinetex EVO C18 core-shell.
