All News

Leaks in GC–MS are particularly insidious. How do you know when you have a leak and where do you start to look for it. It is something that will happen to all chromatographers at some point. Here is our quick guide to how to identify the source of GC–MS leaks.

App of the month: GPC Glossary

Waters Corporation and PSS GmbH have announced the return of the International GPC/SEC Symposium to be held at The Westin Grand Frankfurt Hotel in Frankfurt, Germany, on 30 September–2 October 2014.

Thirty percent of approved drugs will be based on recombinant monoclonal antibody (rMab) drugs over the next 10 years. Glycosylation, the convalent addition of carbohydrates to proteins, can influence properties of rMab drugs and has to be closely monitored during drug development and production. Scientists from the University of California (California, USA) have developed a new liquid chromatography–mass spectrometry (LC–MS) N-glycan library based on eight commercially available recombinant monoclonal antibodies, for the rapid identification of glycosylated structures.

Scientists from Emory University (Georgia, USA) have developed a new solid–phase extraction (SPE) method to isolate four insecticide degradates from baby food for analysis by high performance liquid chromatography tandem mass spectrometry (HPLC–MS–MS). The paper published in the Journal of Agricultural and Food Chemistry describes how the method can be applied to differentiate between exposure to insecticides or preformed degradates.

The study of sewage using chromatographic techniques is a rapidly expanding area that can provide insights into the consumption of illicit drugs. Measuring illicit drug concentrations can provide authorities with a close to real time identification of consumption trends and rates in specific geographical areas.

This article presents a method that combines combustion digestion and ion chromatography into a single analysis (combustion ion chromatography [CIC]) making it possible to detect halogens and sulphur in complex matrices. The method is suitable for use in a wide range of application areas.

An excerpt from LCGC's e-learning tutorial on HPLC problems at CHROMacademy.com.

Click the title above to open The Column July 07, 2014 North American issue, Volume 10, Number 12, in an interactive PDF format.

In the first video update to LCGC TV of 2015, Gérard Hopfgartner from the University of Geneva, University of Lausanne, Switzerland, discusses the advances in ion mobility mass spectrometry, highlighting the benefits of the technique and how it can be hyphenated to both 1D and 2D LC.

The LCGC Europe news update from July 3 2014.

Wyatt Technology Corporation

Malvern Instruments Ltd.

Safe and effective gas cylinder setup and use requires the right pressure regulators, fittings, tubing, and filters as well as careful attention to procedure. This month's instalment reviews how to get the best results from laboratory gas cylinders, how pressure regulators work, and what filters should be installed in gas lines.

This year's symposium was held in New Orleans, Louisiana, USA. In this review, Ron Majors covers HPLC and UHPLC column and sample preparation highlights, summarizes the awards presented, and reviews the overall liquid-phase chromatographic trends.

A review of Professor Barry L. Karger's years as a teacher and mentor, as well as his many scientific accomplishments

Events

The development of fast and straightforward processes of sample preparation, separation, and detection for the analysis of various food and pharmaceutical samples with a high matrix load are described.

Click here to view the complete E-Separation Solutions newsletter from July 1, 2014.

A fast, sensitive and accurate quantitative method was developed using HPLC–MS–MS for analysis of phthalate metabolites in urine samples.

Kevin Dorfman discusses his work to improve electrophoresis and nanochannel technologies to obtain genomic information.

Why should you be concerned about mobile-phase degassing - it's all done automatically, isn't it?

In this article, we discuss radical MS, an increasingly important area of MS development and the application to bioanalysis. At the current stage, most of the research is performed by a small set of academic groups; it is likely that these types of fundamental studies will attract more attention and even be commercialized in the near future.

LCGCPrimer1013r1

LCGC and Spectroscopy magazines are seeking contributed manuscripts for the March 2015 issue of Current Trends in Mass Spectrometry.

We present a brief review of this year's ASMS conference, which took place June 14–19, 2014, in Baltimore, Maryland

LCGC Print Ad Specs

Click the title above to open the LCGC Europe July 2014 regular issue, Vol 27 No 7, in an interactive PDF format.