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Gas Chromatography with Vacuum Ultraviolet Absorption Detection

LCGC Blogger Tony Taylor provides his impartial guide to liner selection that is representative of the considerations in modern capillary gas chromatography (GC).

This article describes a simple, more convenient method than traditional solid-phase extraction (SPE)-based methods for highly sensitive PPCP detection using triple quadrupole liquid chromatography–mass spectrometry (LC–MS–MS).

Ultrahigh-pressure liquid chromatography (UHPLC) columns are used in peptide mapping to improve the resolution of highly complex peptide mixtures. It is commonly assumed that small particle columns increase performance, but this is not always the case. This study presents a comparison of peak count, column length, and resolution between core–shell and fully porous UHPLC columns.

Waters Corporation and PSS GmbH have announced the return of the International GPC/SEC Symposium to be held at The Westin Grand Frankfurt Hotel in Frankfurt, Germany, on 30 September–2 October 2014.

A team of scientists from the University of Muenster and the University of Siegen in Germany has demonstrated the use of low temperature plasma desorption/ionization orbitrap high-resolution mass spectrometry (LTP–Orbitrap–HR–MS) for the analysis of pesticide residues in fruit.

The LCGC Europe news update from September 4 2014.

Click here to view the complete E-Separation Solutions newsletter from September 4, 2014.

Click the title above to open The Column September 08, 2014 North American issue, Volume 10, Number 16, in an interactive PDF format.

Split/splitless injectors typically vaporize a sample dissolved in a suitable organic solvent under increased temperature. The sample vapors are entrained into the carrier gas flow inside a "liner" or "sleeve" within the inlet and from there pass into the column or out of the inlet via the "split" line/valve.

Edible oils and fats are complex mixtures of compounds. This article describes the role of normal-phase liquid chromatography as a generic sample pretreatment tool prior to detailed gas chromatography (GC) analysis.

Advances in nano-ultrahigh-performance liquid chromatography–mass spectrometry (nUHPLC) and micro–UHPLC (?UHPLC) are described and evaluated, with reference to the analysis of veterinary drugs and steroids in porcine meat and urine, respectively.

Click the title above to open the LCGC Europe September 2014 Advances in Food Analysis Supplement, Vol 27 No s9, in an interactive PDF format.

Paper spray mass spectrometry (MS) allows for the direct analysis of pharmaceuticals, drugs of abuse, and other small molecules from blood, urine, and other biofluids (1,2).

Chromatography data systems (CDSs) have had a starring role in many regulatory citations involving falsification and fraud in analytical laboratories regulated by Good Manufacturing Practices (GMP). In this instalment of "Questions of Quality" we will examine the citations and identify the technical and procedural controls required to ensure data integrity within these systems. Although focused primarily on the pharmaceutical industry, the principles described here are applicable to all laboratories working to established quality standards.

This year's HPLC symposium was held in New Orleans, Louisiana, USA. In this review, Ron Majors covers HPLC and UHPLC column and sample preparation highlights, summarizes the awards presented, and reviews the overall liquid-phase chromatography trends.

How can resolution be determined when peak width cannot be measured?

A review of the essential elements of MS approaches to protein quantification and a critical comparison of the available options

The numerous advantages of translating gradient chromatographic methods between the differing formats of liquid chromatography (LC) have been explored and discussed.

Many problems encountered executing HPLC methods are a result of decisions made during early method development. This article discusses one critical variable in method development, the choice of stationary phase chemistry.

An investigation into some "typical" HPLC method specifications to highlight ways of critically evaluating the major and minor parameters of a method

An efficient method for forensic analysis of amphetamines and synthetic cathinones - the illicit drugs often called "bath salts" - in hair samples.

This article describes ways to apply quality-by-design principles to build in a more scientific and risk-based multifactorial strategy in the development of an ultrahigh-pressure liquid chromatography (UHPLC) method for omeprazole and its related impurities.

A look at what's in store for chromatographers at the Analytica China Conference. The conference and the exhibition will take place at the Shanghai New International Expo Center, Shanghai, People's Republic of China, from 24–26 September 2014.

Since the gas flow required for the separation step in gas chromatography is frequently lower than that required to optimize the detection, nitrogen is used as a make-up gas to increase the gas flow for detection.

Click the title above to open the LCGC Asia Pacific September 2014 regular issue, Vol 17, No 3, in an interactive PDF format.

Click the title above to open the LCGC Europe September 2014 regular issue, Vol 27, No 9, in an interactive PDF format.

Click the title above to open the LCGC North America September 2014 regular issue, Vol 32 No 9, in an interactive PDF format.