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This article shows the potential of IC–ICP–MS for monitoring iodine-containing ionic oxidation by-products that form during ozonation of iodinated X-ray contrast media.

Researchers from Kaohsiung Medical University in Taiwan have been investigating melamine and have shown that melamine tableware is a potential source of melamine exposure and that workers in a melamine tableware factory are subsequently at a higher risk of renal injury associated with ambient melamine exposure.

This article shows the potential of IC–ICP–MS for monitoring iodine-containing ionic oxidation by-products that form during ozonation of iodinated X-ray contrast media.

Finding Time for Thinking Time

Three-Dimensional Thinking

Click the title above to open the LCGC North America September 2015 Application Notebook, Vol 33 No s9, in an interactive PDF format.

Ion-mobility spectrometry (IMS) is an anlytical technique that provides for the separation of ions in the gas phase. The separation, occuring on a timescale of milliseconds, is based on the differing mobility of ions according to their charge, shape, and size. These characteristics make IMS suitable for coupling with mass spectrometry (MS), to serve in current MS-based workflows for metabolomics and lipidomics. IM-MS improves peak capacity and signal-to-noise ratios, and it provides more confidence during compound identification or confirmation than conventional analyses. Combining collision-induced dissociation with ion-mobility separation improves the specificity of MS/MS-based approaches. Significantly, ion-mobility-derived information provides an orthogonal, physicochemical parameter-the collision cross section (CCS)-which relates to a metabolite's shape. Novel hardware and software solutions enable analysts to process and exploit IMS-MS data for qualitative and quantitative metabolomics and lipidomics applications.

A simple and accurate method for determining trace level of carcinogenic solvent carbon tetra chloride (CCl4) in Flunixin Meglumine, a drug substance which is white crystalline powder was developed by Gas chromatography .The method was observed to be robust and complete analytical method validation was performed and meets the requirements as per ICH guidelines. The method possesses the lowest detection level when compared with other methods currently available. The LOQ achieved by this method was 0.8 ppm and calibration curves were linear, R >0.998.In general, for analysis of halogenated compounds electron capture detector (ECD) were mostly used and in this proposed method flame ionization detector (FID) with internal standard was used. The method was implemented for various Active pharmaceutical ingredients (API) successfully.

Improve your headspace sampling methods through a deeper understanding of the effects of key method parameters

Ion-mobility spectrometry (IMS) is an analytical technique that provides for the separation of ions in the gas phase. The separation, occuring on a timescale of milliseconds, is based on the differing mobility of ions according to their charge, shape, and size. These characteristics make IMS suitable for coupling with mass spectrometry (MS), to serve in current MS-based workflows for metabolomics and lipidomics. IMS–MS improves peak capacity and signal-to-noise ratios, and it provides more confidence during compound identification or confirmation than conventional analyses.

The 14th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-14) will be held from 27–29 January 2015 in Ghent, Belgium.

No matter where you live or who you work for, you’re likely to encounter one or more of these liquid chromatography (LC) column problems at some point.

Limonin was separated from other components in citrus juice sample matrices by reversed-phase chromatography with ultraviolet detection.

The 42nd International Symposium of High Performance Liquid Phase Separations and Related Techniques (HPLC 2015), chaired by Gérard Hopfgartner was held 21–25 June in Geneva, Switzerland. This instalment covers some of the highlights observed at the symposium including stationary-phase developments, particle technology, and areas of growing application of HPLC. In addition, trends and perspectives on future developments in HPLC culled from the conference are presented.

As flame ionization detection (FID) approaches its 60th anniversary in 2017, this instalment examines the crucial role that it has played and continues to play for all types of gas chromatography (GC). Without FID, the early development of GC would have proceeded more slowly, especially in the petroleum industry and related hydrocarbon application areas.

Click the title above to open the LCGC Asia Pacific September 2015 regular issue, Vol 18, No 3, in an interactive PDF format.

Click the title above to open the LCGC Europe September 2015 regular issue, Vol 28, No 9, in an interactive PDF format.

Click the title above to open the LCGC North America September 2015 regular issue, Vol 33 No 9, in an interactive PDF format.

Ion-mobility spectrometry (IMS) is an analytical technique that provides for the separation of ions in the gas phase. The separation, occuring on a timescale of milliseconds, is based on the differing mobility of ions according to their charge, shape, and size. These characteristics make IMS suitable for coupling with mass spectrometry (MS), to serve in current MS-based workflows for metabolomics and lipidomics. IMS–MS improves peak capacity and signal-to-noise ratios, and it provides more confidence during compound identification or confirmation than conventional analyses.

LCGC TV: Luigi Mondello on the Fundamentals of 2D LC Comprehensive liquid chromatography (LC) is a multidimensional technique that has the potential to increase peak capacity resolution when separating complex mixtures, especially in food analysis.