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Malvern Instruments Secures ?3 million from UK Government

10 common GC mistakes - are you guilty of making them?

Scientists at the University of Cambridge (Cambridge, UK) have reconstructed the early conditions of the Earth?s oceans to find that spontaneous chemical reactions could have generated the first biological molecules, before the evolution of organisms or the existence of enzymes.1 The study published in the journal Molecular Systems Biology presents data collected from liquid chromatography?triple quadrupole mass spectrometry (LC–QTOF–MS) suggesting that reactions central to our core metabolism could have spontaneously occurred.

It's just a silica support with a C18 bonded on, surely there can't be much difference between them? Wrong.

Over the last 30 years, the occurrence of head and neck cancer in Spain has been increasing, and now accounts for between 5–10% of malignant tumours diagnosed each year.1 In a new study published in the journal Chromatographia, solid-phase microextraction (SPME) with gas chromatography coupled to mass spectrometry (GC–MS) has been performed to identify two potential biomarkers of epidermoid laryngeal cancer, that could be used in non-invasive diagnostic testing.

The latest newsletter from May 29.

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Click here to view the complete E-Separation Solutions newsletter from May 27, 2014.

Agilent Technologies (California, USA) is to collaborate with Seoul National University (Seoul, South Korea) to open a new research centre that will support the College of Pharmacy?s New Drug Development Centre.

Incognito speculates on how 3D printing could change life in the laboratory.

This article presents a new method to evaluate the temperature shift observed in analytical temperature rising elution fractionation (ATREF). The evaluation is based on the dependence of the measured peak temperature as a function of heating rates. Application of the proposed method does not require any knowledge of the fluid circuit characteristics geometry and avoids the use of narrow preparative TREF standards. The results are found to be more accurate than the method that is usually applied.

The latest newsletter from May 22.

Click the title above to open The Column May 22, 2014 North American issue, Volume 10, Number 9, in an interactive PDF format.

Click the title above to open The Column May 22, 2014 Europe & Asia issue, Volume 10, Number 9, in an interactive PDF format.

Anthony Gravell of Natural Resources Wales discusses the principles of passive sampling and the advantages of the technique over spot sampling when screening water samples for environmental contaminants.

James Frahill, Research Analyst, Pfizer Process Development Centre, spoke to LCGC about the role of the chromatographer in the pharmaceutical process development group at Pfizer.

The 41st International Symposium on High Performance Liquid Phase Separations and Related Techniques took place from 11?15 May 2014 in New Orleans, USA. One of the highlights of the conference was the poster presentation sessions, which were entered into a competition for the Agilent Technologies Best Poster Award.

A new study in the journal Heart suggests that high performance liquid chromatography tandem mass spectrometry (HPLC?MS?MS) could be performed as a standard screening tool to identify patients who do not take the anti-hypertensive medications as prescribed by their doctor. 1 The authors suggest that up to one in four patients is misdiagnosed as suffering with ?resistant hypertension?, when in fact the patient has not been taking their prescribed medications as advised.1

Many troubleshooting investigations in chromatography often don?t lead to a single causal factor. Often, the reason for problems or lack of method robustness are related to many small ?contributory factors? and this is particularly true of the problems associated with sample introduction in capillary Gas Chromatography.

The latest newsletter from May 15.

A study published in the journal Environmental Science and Technology suggests a strong link between oil and gas emissions and the high production of ozone in the atmosphere during the winter months in the Uintah Basin in Utah, USA.1 Scientists from the Institute of Arctic and Alpine Research (INSTAAR) at the University of Colorado in the USA performed continuous measurements of ozone, methane, and a suite of nonmethane hydrocarbons (NMHCs) above the basin between January and February in 2012 and 2013.

Steroid testing is commonly associated with sports doping testing to monitor athletes for performance-enhancing compounds, but it also important in the food industry for consumer safety. A new method using high-temperature liquid chromatography with photodiode detection and isotope ratio mass spectrometry (HT?LC?PDA?IRMS) that does not require sample derivatization and uses water as the eluent has been developed by scientists at the University of Duisberg-Essen in Essen, Germany.1

The 2014 Lifetime Achievement in Chromatography Award is granted to Fred E. Regnier. Here we chart his career and accomplishments.

Mohamed Abdel-Rehim, professor of analytical chemistry at Stockholm University in Stockholm, Sweden, spoke to Bethany Degg of The Column about a novel approach to determine drug intake using saliva samples.

An excerpt from LCGC's e-learning tutorial on core–shell particles for HPLC at CHROMacademy.com

Benzodiazepines are extensively misused as a result of their hypnotic-sedative properties and relative availability, and they are often used in combination with other drugs, which can result in life-threatening conditions. This article presents a SPE and LC–MS method for the analysis of benzodiazepines in synthetic urine samples.

Click the title above to open The Column May 12, 2014 North American issue, Volume 10, Number 8, in an interactive PDF format.

Click the title above to open The Column May 12, 2014 Europe & Asia issue, Volume 10, Number 8, in an interactive PDF format.