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The pyrolysis–GC–MS method enables direct analysis of solid or liquid polymers without sample pretreatment, as illustrated here for various materials, including a dental filling material and a car wrapping foil.

An analytical method based on liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) has been developed for the determination of acrylamide in water. To obtain clean extracts and low detection limits, an activated carbon cartridge was investigated for use in solid-phase extraction (SPE), and extraction conditions such as desorption solvent and elution volume were optimized by a series of experiments. High recoveries (99.1–99.8%) were obtained using the activated carbon solid-phase extraction cartridges with methanol as the eluent. This method could be applied to the quantification of acrylamide in environmental water samples.

Sample preparation has often been viewed as the bottleneck in analytical procedures. Surveys have shown that time is typically the most frequent problem area for sample preparation procedures. While newly developed extraction techniques address time, modern chromatography advances are also moving towards faster separations. Based on these considerations, what is high-throughput sample preparation? Do modern extraction methods adequately address the issue of time? How can we address the analytical need for speed?

This review provides an updated overview of the theory behind the success of SPP technology, trends, benefits, and limitations. It also summarizes the latest developments of sub-2-?m SPPs and instrumental constraints associated with their use.

This fast, sensitive method provides accurate quantitation.

UV detectors are the most common LC detector, and perhaps the most reliable ones. But they are not without problems.

Some attributes of large molecules make them behave differently from small molecules in reversed-phase separations.

What brought this scientist to where he is? And where he is going next?

Click the title above to open the LCGC Asia Pacific June 2014 regular issue, Vol 17, No 2, in an interactive PDF format.

Click the title above to open the LCGC North America June 2014 regular issue, Vol 32 No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2014 Application Notebook, Vol 32 No s6, in an interactive PDF format.

Malvern Instruments Secures ?3 million from UK Government

10 common GC mistakes - are you guilty of making them?

Scientists at the University of Cambridge (Cambridge, UK) have reconstructed the early conditions of the Earth?s oceans to find that spontaneous chemical reactions could have generated the first biological molecules, before the evolution of organisms or the existence of enzymes.1 The study published in the journal Molecular Systems Biology presents data collected from liquid chromatography?triple quadrupole mass spectrometry (LC–QTOF–MS) suggesting that reactions central to our core metabolism could have spontaneously occurred.

It's just a silica support with a C18 bonded on, surely there can't be much difference between them? Wrong.

Over the last 30 years, the occurrence of head and neck cancer in Spain has been increasing, and now accounts for between 5–10% of malignant tumours diagnosed each year.1 In a new study published in the journal Chromatographia, solid-phase microextraction (SPME) with gas chromatography coupled to mass spectrometry (GC–MS) has been performed to identify two potential biomarkers of epidermoid laryngeal cancer, that could be used in non-invasive diagnostic testing.

The latest newsletter from May 29.

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Click here to view the complete E-Separation Solutions newsletter from May 27, 2014.

Agilent Technologies (California, USA) is to collaborate with Seoul National University (Seoul, South Korea) to open a new research centre that will support the College of Pharmacy?s New Drug Development Centre.

The 2014 Emerging Leader in Chromatography Award was presented to Andrè de Villiers. Here we chart his career and accomplishments so far.

Incognito speculates on how 3D printing could change life in the laboratory.

This article presents a new method to evaluate the temperature shift observed in analytical temperature rising elution fractionation (ATREF). The evaluation is based on the dependence of the measured peak temperature as a function of heating rates. Application of the proposed method does not require any knowledge of the fluid circuit characteristics geometry and avoids the use of narrow preparative TREF standards. The results are found to be more accurate than the method that is usually applied.

The latest newsletter from May 22.

Click the title above to open The Column May 22, 2014 North American issue, Volume 10, Number 9, in an interactive PDF format.

Click the title above to open The Column May 22, 2014 Europe & Asia issue, Volume 10, Number 9, in an interactive PDF format.

Anthony Gravell of Natural Resources Wales discusses the principles of passive sampling and the advantages of the technique over spot sampling when screening water samples for environmental contaminants.

James Frahill, Research Analyst, Pfizer Process Development Centre, spoke to LCGC about the role of the chromatographer in the pharmaceutical process development group at Pfizer.