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When developing a separation, some fundamental choices need to be made on how we might achieve the separation we require - primarily the mode of chromatography used and the way in which we intend to control and optimise the retention and separation (selectivity) of analyte components.

This Monday afternoon session, MOC, will be presided over by Gert Von Helden of Fritz-Haber University. The session will run from 2:30?4:30 p.m. in room 309-310.

Multi-detection GPC/SEC is described and new data showing how the technique is being used to determine the impact of sterilization on medical grade poly(L-lactide) is presented.

This Monday morning session will be presided over by Patrick Limbach of the University of Cincinnati and will be held at 8:30?10:30 a.m. in Room 307-308.

A new study in the journal Heart suggests that high performance liquid chromatography tandem mass spectrometry (HPLC?MS?MS) can be performed as a standard screening tool to identify patients who do not take the anti-hypertensive medications as prescribed by their doctor.1

GPC/SEC can be performed for samples that range from a few hundred to several million daltons in molar mass. It can often require more skill to analyze high molar mass samples in the molar mass range of several million dalton. This article explains more.

The use of high temperature adsorption liquid chromatography for the characterization of polyolefins is detailed.

Red wine could help to protect against oral cavities, according to research published in the Journal of Agricultural and Food Chemistry.1 The team used ultrahigh-pressure liquid chromatography tandem mass spectrometry together with electrospray ionization (UHPLC–ESI–MS–MS) to analyze phenolic compounds found in the sampled red wine.

Today?s plenary is an award lecture by Richard M. Caprioli of Vanderbilt University. Caprioli is the recipient of the 2014 ASMS Award for a Distinguished Contribution in Mass Spectrometry for the development of matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry and its application to molecular mapping of tissues in biology and medicine. His award lecture today will be held in Exhibit Hall AB, at 4:45 pm.

Matthew Crowe, of Dow Chemical (Midland Michigan), will preside over six Monday morning oral sessions on ?Emerging Environmental Contaminants.? The sessions will take place in Exhibit Hall AB between 8:30 a.m. and 10:30 a.m.

Kate Mosford of The Column spoke to Giorgia Purcaro of the Department of Food Science at the University of Udine, Italy, and Chiara Cordero of the Department of Drug Science and Technology at the University of Turin, Italy, about the sensory evaluation of olive oil and the benefits of a comprehensive approach.

Click here to view the complete E-Separation Solutions newsletter from June 5, 2014.

DNA can be analyzed by many techniques, including electrophoretic techniques such as gel, capillary, and microchip electrophoresis, and nanochannel methods in which DNA is labeled and stretched. This interview with Kevin Dorfman, an Associate Professor in the Department of Chemical Engineering and Materials Science at the University of Minnesota in Minneapolis, Minnesota, discusses his research with polymer physics and microfluidic and nanofluidic technologies.

Click the title above to open The Column June 05, 2014 North American issue, Volume 10, Number 10, in an interactive PDF format.

Click the title above to open The Column June 05, 2014 Europe & Asia issue, Volume 10, Number 10, in an interactive PDF format.

Advances in mass spectrometry instrumentation have opened up the field of metabolomics, but there are still issues with non-standardized sampling and sample preparation methods. Tuulia Hyötyläinen from the VTT Technical Research Centre of Finland discusses the vast range of sample matrices and gives advice on best practices.

The chemistry of radicals - which is quite different from that of even-electron species - opens up new analytical capabilities.

The pyrolysis–GC–MS method enables direct analysis of solid or liquid polymers without sample pretreatment, as illustrated here for various materials, including a dental filling material and a car wrapping foil.

An analytical method based on liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) has been developed for the determination of acrylamide in water. To obtain clean extracts and low detection limits, an activated carbon cartridge was investigated for use in solid-phase extraction (SPE), and extraction conditions such as desorption solvent and elution volume were optimized by a series of experiments. High recoveries (99.1–99.8%) were obtained using the activated carbon solid-phase extraction cartridges with methanol as the eluent. This method could be applied to the quantification of acrylamide in environmental water samples.

Sample preparation has often been viewed as the bottleneck in analytical procedures. Surveys have shown that time is typically the most frequent problem area for sample preparation procedures. While newly developed extraction techniques address time, modern chromatography advances are also moving towards faster separations. Based on these considerations, what is high-throughput sample preparation? Do modern extraction methods adequately address the issue of time? How can we address the analytical need for speed?

This review provides an updated overview of the theory behind the success of SPP technology, trends, benefits, and limitations. It also summarizes the latest developments of sub-2-?m SPPs and instrumental constraints associated with their use.

This fast, sensitive method provides accurate quantitation.

UV detectors are the most common LC detector, and perhaps the most reliable ones. But they are not without problems.

Some attributes of large molecules make them behave differently from small molecules in reversed-phase separations.

What brought this scientist to where he is? And where he is going next?

Click the title above to open the LCGC Asia Pacific June 2014 regular issue, Vol 17, No 2, in an interactive PDF format.

Click the title above to open the LCGC Europe June 2014 regular issue, Vol 27 No 6, in an interactive PDF format.

Click the title above to open the LCGC North America June 2014 regular issue, Vol 32 No 6, in an interactive PDF format.