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The applications of liquid chromatography and mass spectrometry play a key role in pharmaceutical and biological processing.

Two different methods of calculating the LLOQ disagree. Which, if either, is correct?

Chiral separation screening has become a widely accepted approach for the rapid identification of an appropriate chiral stationary phase for use in more focused enantioseparation optimization. A set of extended screens encompassing various chromatographic modes using HPLC and SFC is presented.

This instalment describes more popular myths or half-truths in UHPLC and provides data that contradict or even repudiate some of these commonly held beliefs.

LCGC North America Editorial Calendar

Questions about how practical proposed gas chromatography (GC) method changes are often come up during optimization for speed and resolution, or while converting to a different carrier gas. Related objective measurements such as the optimum practical carrier gas velocity were defined more than 40 years ago. This instalment reviews such metrics in the light of their relevance to today's GC challenges.

In the final part, the top 10 HPLC and UHPLC column myths are presented and attempts are made to demystify them by offering some evidence that they are untrue. This part will feature myths five to one.

There are many ways to improve retention or selectivity in reversed-phase HPLC and knowledge of the key eluent variables to achieve this is essential reading.

LCGC North America June 2013 BPA Statement

Two different methods of calculating the LLOQ disagree. Which, if either, is correct?

In any field, there are "misconceptions" or "myths" that arise and are perpetuated and passed on to the next generation. These myths are often driven by a lack of understanding of the real issues by practitioners. In the first of a two-part feature from Ron Majors, the top 10 high performance liquid chromatography (HPLC) column myths are presented and attempts are made to demystify them by offering some evidence that they are untrue. This part will feature myths 10 to six.

Events

The Coblentz Society, an affiliate of the Society of Applied Spectroscopy, was approached with a challenge from an anonymous donor during the SciX13 conference.

Click the title above to open the LCGC Asia Pacific November 2013 regular issue, Vol 16, No 4, in an interactive PDF format.

Click the title above to open the LCGC Europe November 2013 regular issue, Vol 26 No 11, in an interactive PDF format.

Click the title above to open the LCGC North America November 2013 regular issue, Vol 31 No 11, in an interactive PDF format.

Discarded silicone explants, a waste material from the cosmetic surgery industry, could be a new source of sample material for studying POP accumulation in humans.

LCGC Europe E-newsletter 31/10/2013: Tips for Surviving a Zombie Attack in the Laboratory

Two samples of styrene-butadianoene rubbers (SBR) were analyzed by SEC and AF4 coupled with a MALS detector.

This article demonstrates the application of a MALS detector within a triple detector array to measure absolute molecular weight distribution of hyaluronic acid.

Incognito investigates if chromatographers should become scientists or managers to advance their careers.

Although gel permeation chromatography (GPC) is not as widely used as other chromatography methods, it continues to be a useful technique for analyzing the size and solution characteristics of organic polymers. In this study, GPC was applied to analyze different polar polymers that are commonly used in drug excipients. As a result of their polarity, some specialized operating conditions were required. Optimizing the separation brought to light many of the common parameters involved in optimizing GPC separations, and those are discussed in detail here.

The National Institutes of Health (NIH) has recently awarded several grants totalling $1.86 million to the University at Buffalo?s HIV Clinical Pharmacology Research Programme. The grants are to be used to fund new initiatives in hepatitis C (HCV) drug development, nanomedicine research for tuberculosis (TB), and for the study of pharmacogenomics of neurocognitive disorders for people with HIV and AIDS.

The National Institutes of Health (NIH) has recently awarded several grants totalling $1.86 million to the University at Buffalo?s HIV Clinical Pharmacology Research Programme. The grants are to be used to fund new initiatives in hepatitis C (HCV) drug development, nanomedicine research for tuberculosis (TB), and for the study of pharmacogenomics of neurocognitive disorders for people with HIV and AIDS.

Agilent Technologies (California, USA) has announced a strategic collaboration with Seoul National Hospital (Seoul, Korea). The collaboration will focus on the identification and verification of biomarkers to further the development of drugs. Under the agreement, the hospital?s department of medicine will use liquid chromatography?mass spectrometry (LC?MS) instrumentation from Agilent to further research in this area

Malvern Instruments (Malvern, UK) has opened a new office in Mexico City, Mexico, to provide pre- and after-sales support to a growing customer base, in addition to hosting a number of training courses. The announcement follows the opening of a sales and applications laboratory in Sao Paolo, Brazil, last year.

Don?t miss out on a free webcast about key factors to consider when selecting a laboratory service provider , to ensure that you add significant value to your laboratory business.

Editors? Series: Fundamentals, Optimization and Practical Aspects of UHPLC: Series 2: Optimization of UHPLC systems and column technology