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Researchers recently developed fluorinated solid phase microextraction (SPME) materials that improve the selective extraction and chromatographic detection of volatile per- and polyfluoroalkyl substances (PFAS) from complex samples. LCGC International spoke to the authors of the paper resulting from this work.

Capillary liquid chromatography (CapLC) offers compelling advantages in sensitivity, solvent reduction, and compatibility with modern mass spectrometry, yet remains underutilized in routine analytical workflows. This article synthesizes expert discussions from a Pittcon 2026 networking session to examine why CapLC adoption has lagged despite decades of development. Key themes include educational gaps, instrumentation limitations, robustness concerns, detection challenges, and supply‑chain constraints. The discussion highlights areas where CapLC already delivers clear value—such as proteomics, oligonucleotide analysis, and high‑throughput screening—and outlines practical pathways for broader adoption through targeted applications, improved instrumentation, and redefined expectations of “routine” chromatography.