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In this month's LCGC Blog, Caitlin Cain from the University of Virginia examines whether technological advances in chromatography—particularly the adoption of big data, artificial intelligence (AI), and machine learning (ML)—are reducing the emphasis on the fundamental chromatographic theory that is key to understanding the technique.

In the third of this four-part series, Yifan Liu of Northeastern University (Boston, MA) discusses the a need for dedicated LT-ZIC-HILIC retention time library for metabolic research.

Jonathan Maurer from the University of Geneva, Switzerland describes using HILIC for oligonucleotide analysis in practice and the role of HILIC for other biopharmaceutical applications.

Jonathan Maurer from the University of Geneva, Switzerland describes some of the challenges and misconceptions surrounding hydrophilic interaction chromatography (HILIC) and oligonucleotide analysis.

Gas chromatography (GC) measures volatile sulfur compounds (VSCs) in breath samples to assess remote halitosis diagnosis reliability.

Ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) identifies phenolic compounds driving honey's bioactive properties

In the second of this four-part series, Yifan Liu of Northeastern University (Boston, MA) discusses the biggest bottlenecks in untargeted metabolomics right now.

Wallman argues proteomics is moving from niche tool to high-throughput platform core, with the greatest untapped potential in covalent drug programs and targeted protein degradation.

Meet the expert panel exploring the analytical challenges of environmental PFAS detection in this LCGC International Peer Exchange®.

Liquid chromatography-mass spectrometry (LC-MS) reveals how flunitrazepam degrades post-mortem, aiding forensic overdose confirmation.

In the first of this four-part series, Yifan Liu of Northeastern University (Boston, MA) discusses her ASMS 2026 presentation, Low-Temperature HILIC Provides Enhanced Separations and Stability for LC–MS-Based Metabolomics.

Wallman explains that PeptDeepKontext is designed to generalize without lab-specific calibration, though highly unusual setups may still benefit from additional fine-tuning in the future.

Gas chromatography-mass spectrometry (GC-MS) and spectroscopy confirm algae biodiesel as a potential clean, efficient fuel.

AI and robotics are converging to make chromatographic method development faster and smarter.

LCGC International spoke to Sandy Al Bardawil and Ludivine Ferey, authors of a review article summarizing recent advances in chromatographic methods coupled with MS for the characterization of therapeutic oligonucleotides.

Wallman unpacks how graph-level fragmentation in fragDETR captures internal fragments and neutral losses, with peak and intensity improvements concentrated in challenging non-standard peptides.

High performance liquid chromatography (HPLC) verifies creatine uptake via two distinct transporter genes in rainbow trout.

This week's Chromatography Online highlights span LC solvent mismatch solutions, advanced PFAS monitoring by GC–MS and TD–GC–MS, deep learning in DIA proteomics, multidimensional LC–MS for plant extracts, PEG column guidance, and LC–MS/MS and GC–MS applications in consumer product safety and disease research.

Liquid chromatography-mass spectrometry (LC–MS) plasma nicotine data trains machine learning (ML) models for vaping exposure.

Nikoline Juul Nielsen from the University of Copenhagen, Denmark explores deprotomer formation for accurate CCS prediction and metabolite identification and the potential of implementing these workflows for routine use.

LCGC International spoke with Nikoline Juul Nielsen from the University of Copenhagen, Denmark on the benefits of RPLC×HILIC–cIMS for data-independent profiling of phenolic constituents in plant extracts. In this episode she explores practical aspects of cIMS and the potential for routine analysis.

Wallman explains how spectral library accuracy, retention time prediction, and instrument-specific variation make deep learning essential yet difficult in data-independent acquisition proteomics.

Gas chromatography–mass spectrometry (GC–MS) was used in the profiling of links between gut bacteria and metabolites to myasthenia gravis.

LCGC International spoke with Nikoline Juul Nielsen from the University of Copenhagen, Denmark about the benefits of comprehensive two-dimensional liquid chromatography (RPLC×HILIC)—cyclic ion mobility-time-of-flight mass spectrometry (cIMS) for analyzing plant extracts.

Practical GC in gas chromatography: learn how PEG column bleed affects MS sensitivity, and when polar analytes still quantify reliably.

AI promises to solve cost, labor, and regulatory challenges, but a shortage of deployment expertise means it can create more problems than it solves.

High performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP-MS) reveal how diet and sunlight shape grey parrot nutrient levels.

Discover LC–MS chromatography strategies that tackle PFAS at ppt levels in soil, serum and food, boosting sensitivity, selectivity and confidence.