As NIR and chemometric models rely heavily on chromatographic reference data, Koen Vanhoutte discusses the implications for the future role and expectations of chromatography in analytical science.
Researchers used liquid chromatography–mass spectrometry (LC–MS) to analyze hormone profiles in elite athletes, finding that some athletes with XY differences in sex development (DSD) showed testosterone patterns more similar to male athletes, helping improve understanding of conditions such as androgen insensitivity syndrome and 5α-reductase type 2 deficiency in competitive sports.
Using chromatography–mass spectrometry with ultrasound- and enzyme-based extraction methods, researchers showed that selenium speciation and recovery in broccoli sprouts depend on the extraction approach, providing insight into plant selenium uptake and metabolism relevant to food biofortification.
The 55th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2026) conference will take place from June 6–11, 2026, in Indianapolis, Indiana. Conference Chairs, Todd Maloney from Eli Lilly and Company and Jared Anderson from Iowa State University, highlight what the conference has to offer the chromatography community.
In the first of a four-part interview conducted at analytica 2026, Koen Vanhoutte of Johnson & Johnson Innovative Medicine discusses how self‑optimizing LC workflows are changing the way chromatographic methods are developed compared with traditional trial‑and‑error approaches.
Using liquid chromatography-tandem mass spectrometry (LC–MS/MS) to measure pre-treatment vitamin D levels, researchers found that low vitamin D is associated with a higher risk of severe paclitaxel-induced nerve damage in breast cancer patients.
Element Lab Solutions was officially rebranded as Crawford Scientific on 1st May 2026.
Using high-performance liquid chromatography-mass spectrometry (HPLC–MS) alongside bioassays and microbiota analysis, research has shown that gastrointestinal digestion alters the chemical fate, bioaccessibility, and toxicity of pesticides in apples in a compound-dependent manner.
A chromatography-based, non-heat process removes bitterness from orange juice while preserving its flavor and nutrients. LCGC International spoke to Araceli Rivera‑Pérez, lead author of the paper that resulted from its development.
Using thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS), researchers identified hundreds of wildfire smoke chemicals trapped in firefighter respirator filters and carbon cartridges, including several toxic compounds, highlighting the need for improved respiratory protection design.
Recent highlights in chromatography and mass spectrometry showcased advances in environmental monitoring, biomedical analysis, materials testing, textile safety, planetary science, and scientific communication, demonstrating the expanding impact of LC–MS and GC–MS technologies across research fields.
Rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of wastewater samples across England revealed widespread and fluctuating community drug use patterns—particularly high cocaine and ketamine levels—highlighting the power of chromatography-based methods for real-time public health monitoring.
Waters Corporation reported double-digit organic growth and raised its 2026 outlook as the company begins integrating the recently acquired BD Biosciences and Diagnostic Solutions businesses into its analytical and diagnostic portfolio.
High-performance liquid chromatography (HPLC) analysis showed that the peel of the citrus fruit bushukan contains low levels of key flavonoids, highlighting that presumed health benefits of citrus peels should be confirmed through species-specific chemical testing rather than assumed from fruit type.
Using targeted liquid chromatography–tandem mass spectrometry (LC-MS/MS), researchers showed that many sphingolipid levels rise with age and differ between men and women, highlighting the need for age- and sex-specific reference ranges before these markers can be used in routine health risk assessment.
Alba Rodriguez Otero combined liquid chromatography with high resolution mass spectrometry (LC–HRMS) with hierarchical cluster analysis to interpret the non-targeted features to assess this novel workflow to asses novel materials for wastewater treatment.
Using automated thermal desorption–gas chromatography/mass spectrometry (ATD-GC/MS), researchers detected multiple chemicals in children’s clothing and showed that their presence, washout behavior, and migration into artificial sweat vary strongly depending on fabric type.
Gas chromatography–mass spectrometry (GC-MS) revealed that a stepwise precooling method better preserves key flavor-related aldehydes and esters in cherry tomatoes compared to conventional single-step cooling, helping maintain aroma quality during storage.
Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers mapped where sugar-related collagen crosslinks occur in human bone and found site-specific differences in their distribution and only weak links to bone strength.
Using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) alongside sensory tools, researchers showed that different cooking methods systematically alter the chemical compounds—and therefore the flavor profile—of Yuxiang shredded pork.
Using gas chromatography–mass spectrometry (GC–MS), researchers showed that low, non-lethal exposure to deltamethrin alters key fatty acids in honey bee brains, indicating disrupted neural metabolism that may underlie pesticide-related cognitive effects.
A recent study developed and validated a highly sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) fluorescence method using OPA/ethanethiol derivatization to simultaneously quantify multiple gentamicin C-subtypes in tiny murine perilymph samples, enabling improved pharmacokinetic analysis in the inner ear. LCGC International spoke to Shreshtha Dash and Peter Streyger, two of the authors of the paper that resulted from this study,1 about their work.
Using gas chromatography–mass spectrometry (GC-MS) aboard the Curiosity rover, scientists have identified more than 20 organic compounds in ancient rocks from Gale Crater, revealing a diverse mix of carbon-based molecules and helping advance the search for the origin—and possible biological significance—of organic matter on Mars.
From a preview of HTC-19 in Leuven to cutting-edge insights from analytica 2026, this week’s highlights span breakthroughs in environmental screening, non-invasive diagnostics, green analytical methods, and emerging biomarkers for adolescent mental health.
Liquid chromatography-tandem mass spectrometry (LC–MS/MS) hair analysis combined with surveys at a Portuguese music festival revealed frequent drug use, discrepancies with self-reports, and widespread polydrug exposure, demonstrating chromatography’s value for objective, long-term substance use assessment in high-risk settings.
The advent of large language models for text generation and the ease with which artificial intelligence (AI) can be used for image creation have led to posts that include incorrect information about chromatography to begin to proliferate social media.
Using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and lipidomics, researchers identified obesity-linked biomarkers, highlighting hexanoylglycine and LPC (16:0) as potential causal indicators tied to immune pathways and cardiometabolic risk.
The 35th International Symposium on Chromatography (ISC 2026) will take place from September 6–10, 2026 at the Prague Conference Centre (PCC) in Prague, Czech Republic.
Jef Focant on whether workflows transfer between biological matrices, and which holds the most promise for minimally invasive disease monitoring.
Researchers used high-performance liquid chromatography (HPLC) to identify how 19 breast milk sugars shape healthy gut bacteria in 500 infants, discovering age-specific impacts that persist even after breastfeeding ends.
