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Wallman details PeptDeepKontext, a model built to predict peptide properties across diverse instruments and PTMs by embracing rather than eliminating inter-laboratory variability.

High performance liquid chromatography (HPLC) reveals sugar, acid, and phenolic differences in varieties of grapes.

Restek's three certified reference material (CRM) mixes deliver all native and labeled furans needed for AOAC/EU-compliant food safety analysis.

Gas chromatography-mass spectrometry (GC-MS) and gas-chromatography with flame ionization detection (GC-FID) identify volatile organic compound (VOC) emissions from yard and food waste compost.

High-performance liquid chromatography (HPLC) reveals how burn pit smoke disrupts blood vessels, lungs, and the brain.

Gas chromatography–mass spectrometry (GC–MS) identifies 27 sugar compounds across sweet corn kernel development.

Liquid chromatography-tandem mass spectrometry (LC–MS/MS) testing reveals preservative limit breaches in Danish shampoos and soaps.

Researchers have developed an advanced gas chromatography-mass spectrometry (GC–MS)-based chromatographic method for faster and more sensitive detection of volatile and semi-volatile PFAS in soil, improving environmental monitoring of “forever chemicals” and related contaminants. LCGC International spoke to Maria Chiara Corviseri and Flavio A. Franchina of the University of Ferrara, two of the authors of a paper presenting their method.

This "LC Troubleshooting" column discusses how inline mixing and feed injection mitigate solvent mismatch and peak distortion in liquid chromatography.

Ion-exchange chromatography (IEC) revealed tree species-driven differences in soil carbon and microbial life.

This week, Chromatography Online compiled peer-reviewed research, expert interviews, and news articles spanning chromatography and spectrometry in food analysis.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed vitamin D deficiency strongly linked to childhood obesity.

Antonio Ferracane addresses regulator concerns about cleanup-free PAH methods, noting cleanup isn't mandatory if matrix validation proves reliable.

The approach remains non-targeted by prioritizing PFAS-like ions in the first DDA pass; the tunable mass tolerance window can be adjusted to capture structurally unusual PFAS subclasses.

Christine Fisher describes her method using mass defect filtering at the data acquisition stage to improve non-targeted PFAS detection in complex food matrices.

Headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) combined with machine learning accurately detected fruit juice adulteration.

Blood markers reliably shifted toward healthy diet patterns after counseling.

Antonio Ferracane explains how each sample prep step adds error and can strip target PAHs, so skipping cleanup can improve recovery, accuracy, and precision.

Color imaging and high-performance liquid chromatography (HPLC) reliably predicted pigment levels in carrots.

Hydrophilic interaction chromatography-mass spectrometry (HILIC-MS) profiling tied a senescence gene region to chlorophyll loss and seed protein in sunflowers.

Antonio Ferracane discusses moving to minimal sample preparation for PAH analysis, and why matrix-matched calibration can replace cleanup steps.

Gas chromatography-mass spectrometry (GC-MS) revealed exercise-driven metabolic reprogramming supporting neurogenesis.

For scientists who depend on accurate, traceable data every day, the tools they use matter enormously. Sartorius, a global leader in biopharma research and manufacturing solutions, has introduced its latest generation of laboratory balance—the Cubis III—and it reflects how much the expectations placed on such instruments have changed in recent years.

Gas chromatography with flame ionization detection (GC-FID) showed fermented cassava peel added to chicken feed optimized yolk fatty acid profile in eggs produced.

Electromembrane extraction (EME) uses electric fields and liquid membranes for selective, green microextraction compatible with chromatography.

Antonio Ferracane outlines a combined technique using cryogenic peak compression and pseudo-MRM to sharply boost sensitivity for trace PAHs.

Recent developments in column technology and instrumentation for use in capillary-scale liquid chromatography are discussed. Key motivating factors for the increase in capillary liquid chromatography (LC) usage include a desire for more sustainable analytical methods (including reductions in solvent usage and waste generation) and the need for compact, field-portable systems that can be used in point-of-need settings. To achieve these goals, miniaturization strategies for both column and instrument designs have been required. The impact of these innovations in a variety of application areas—including environmental analysis, forensic testing, and pharmaceutical and biopharmaceutical manufacturing—is described. As the need for greener analytical methods continues to grow, the implementation of low-flow capillary-scale separations will also increase.

Isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) linked higher sleep apnea risk to lower testosterone and sex hormone-binding globulin (SHBG) levels.