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Researchers from the United Kingdom’s National Measurement Laboratory (NML) developed and evaluated a tailored mass spectrometry (MS)-based workflow for the detailed characterization and quantification of rAAV serotype 9 (rAAV9) capsid proteins.LCGC International spoke to Theodoros Kontogiannis from the NML and the lead author of the paper that resulted from this work, about the group’s findings.

This past week, LCGC International published a variety of articles on hot topics in separation science. We discuss how mass spectrometry (MS) unveiled new insights into how music modulates protein networks in lipid nanoparticle delivery and how gas chromatography (GC) can be sed to identify aroma types in unburnt cannabis. Also, we make a call for nominations for the 2026 HTC Innovation Award.

Benzalkonium chloride (BAK) is a common preservative composed of quaternary ammonium compounds with 8–18 carbon alkyl chains, mainly C12, C14, and C16 homologs. Because BAK can adsorb to surfaces, this study highlights the challenges of predicting adsorption behavior and the importance of conducting a vial compatibility assessment early in HPLC method development for dilute solutions of BAK and analytes with similar physicochemical properties.

Researchers at the University of Buffalo used combined middle-up and bottom-up LC–MS/MS to characterize the HIV-1 broadly neutralizing antibody PGT 121. They identified multiple Fc and site-specific glycoforms and an unexpected N-terminal serine, revealing significant structural heterogeneity. This integrated approach enhances understanding of bNAb structure, supporting quality control and clinical development. LCGC International spoke to Troy Wood, corresponding author of the paper resulting from this research.