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Researchers from the United Kingdom’s National Measurement Laboratory (NML) developed and evaluated a tailored mass spectrometry (MS)-based workflow for the detailed characterization and quantification of rAAV serotype 9 (rAAV9) capsid proteins.LCGC International spoke to Theodoros Kontogiannis from the NML and the lead author of the paper that resulted from this work, about the group’s findings.

This LCGC blog highlights the ACS SCSC’s initiatives, events, and awards that connect and support the global separation science community across academia, industry, and government.

David S. Hage discusses how recent developments in immobilization chemistry and materials science are enhancing the performance and versatility of affinity-based separations.

David S. Hage shares how his team is applying microfluidics and miniaturized separation systems to improve speed, reproducibility, and real-world applicability in analytical and bioanalytical chemistry.

This past week, LCGC International published a variety of articles on hot topics in separation science. We discuss how mass spectrometry (MS) unveiled new insights into how music modulates protein networks in lipid nanoparticle delivery and how gas chromatography (GC) can be sed to identify aroma types in unburnt cannabis. Also, we make a call for nominations for the 2026 HTC Innovation Award.

Researchers have developed an enhanced LC-MS/MS method capable of quantifying 18 steroids—including key corticosteroid and sex steroid hormones, as well as intermediates involved in corticosteroid synthesis—in plasma and tail samples collected during the transition of tadpoles into frogs.

David S. Hage, James Hewett University Professor at the University of Nebraska–Lincoln, discusses how advances in affinity-based separations are shaping the future of personalized medicine and transforming clinical diagnostics.

Laura Carbonell-Rozas, a post-doctoral researcher at the University of Granada (Granada, Spain), discusses the potential of natural deep eutectic solvents (NADES) in food analysis as sustainable solvents in sample preparation.

Research focused on the cooking process of marinades used headspace solid-phase microextraction gas chromatography-mass spectrometry to analyze changes and volatilization characteristics of flavor compounds at different cooking times.

A study conducted by a multinational research group investigated the potential of audible sound waves (in the form of music, specifically Pink Floyd’s "Another Brick in the Wall, Part 1") in enhancing nanoparticle neuronal uptake and brain penetration.

Benzalkonium chloride (BAK) is a common preservative composed of quaternary ammonium compounds with 8–18 carbon alkyl chains, mainly C12, C14, and C16 homologs. Because BAK can adsorb to surfaces, this study highlights the challenges of predicting adsorption behavior and the importance of conducting a vial compatibility assessment early in HPLC method development for dilute solutions of BAK and analytes with similar physicochemical properties.

Researchers at Oregon State University and Dow Neurobiology developed a standardized aroma lexicon for characterizing the aromatic attributes of Cannabis inflorescence with an associated sensory method that included the use of gas chromatography in data analysis.

LCGC International and the HTC-19 Scientific Committee celebrate innovation in separation science with the 2026 HTC Innovation Award. Previous winners include Bob Pirok, Szabolcs Fekete, Ryan Kelly and Caroline Huhn.

Researchers at the University of Buffalo used combined middle-up and bottom-up LC–MS/MS to characterize the HIV-1 broadly neutralizing antibody PGT 121. They identified multiple Fc and site-specific glycoforms and an unexpected N-terminal serine, revealing significant structural heterogeneity. This integrated approach enhances understanding of bNAb structure, supporting quality control and clinical development. LCGC International spoke to Troy Wood, corresponding author of the paper resulting from this research.

Discover how women in chromatography are breaking barriers, fostering community, and inspiring the next generation in STEM through mentorship and courage.

Explore the complexities of GLP-1 impurity detection using HPLC/UHPLC and innovative strategies to enhance analysis and regulatory compliance.

Researchers focused on the early stages of developing innovative plant-based active ingredients for skincare, using HPLC to determine which species should be shortlisted for phytochemical profiling.

Giulia Mazzoccanti spoke to LCGC International about the development and application of electrostatic repulsion-reversed phase (ERRP) chromatography for peptide separations.

Metabolomic profiling and the identification of metabolomic markers following HPAI H5N1 infection in chicken was performed in an Indian research study, with metabolite extracts analyzed using LC-MS/MS.

Torgny Fornstedt, Jörgen Samuelsson, and Martin Enmark discuss a novel machine learning workflow for oligonucleotide analysis that is helping to enhance method development and impurity profiling efficiency.

Discover innovative LC–HRMS methods for analyzing RNA-based therapeutics, enhancing biopharma development and regulatory compliance in drug characterization.

Static and dynamic electrostatic repulsion-reversed phase (ERRP) has been compared for the separation of peptide impurities.

Researchers evaluated the antidiabetic potential of peanut oil, known for its high phytochemical content and medicinal properties, using GC-MS to collect and classify fatty acid compounds within the oil.

This episode of Behind the Peaks focuses on the importance of sound statistical practices in chromatographic analysis.

The advancements in HILIC–MS for oligonucleotide analysis are discussed, highlighting its potential as a viable alternative to traditional methods.

The second part of our interview with Annika van der Zon and Andrea Gargano regarding their research developing poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic hydrophilic interaction chromatography columns optimized for protein separation.