A validated chromatographic method was developed for monitoring organochlorine pesticide residues in sesame seeds using QuEChERS sample preparation coupled with gas chromatography–tandem mass spectrometry (GC–MS/MS). The results demonstrate that QuEChERS combined with GC–MS/MS in multiple reaction monitoring (MRM) mode provides a robust, efficient, and reliable chromatographic solution for routine food safety monitoring and regulatory compliance in sesame seed analysis.
Waters Corporation has announced that its shareholders approved the issuance of Waters common stock to shareholders of Becton, Dickinson and Company (BD) in connection with the proposed combination of BD’s Biosciences and Diagnostic Solutions business with Waters.
A comprehensive analytical strategy combining inductively coupled plasma mass spectrometry (ICP-MS) with untargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) was applied to evaluate the chemical composition of commercially available tattoo inks in Australia. The results demonstrate the critical role of LC–MS/MS-based chromatography in uncovering previously uncharacterized toxicants in tattoo inks and underscore the need for harmonized regulatory frameworks and routine chromatographic surveillance to ensure consumer safety.
Rapid native hydrophobic interaction chromatography–mass spectrometry methods have been developed using ammonium tartrate, enabling robust drug-to-antibody ratio and drug load distribution characterization, as well as real-time process analytical technology monitoring of antibody–drug conjugates bioconjugation without complex multidimensional workflows. LCGC International spoke to Bingchaun Wei of the research team about these methods.
Top articles published this week include an interview about a label-free quantitative native proteomics workflow and a preview of the upcoming 44th International Symposium on Capillary Chromatography (ISCC) and the 21st GC×GC Symposium.
Researchers used Design of Experiments approach to optimize gas chromatography with flame ionization detection (GC–FID) for essential oil analysis. The harmonized GC method enables robust, reproducible separation of 87 terpenes using a single column and sample preparation protocol, improving efficiency, standardization, and sustainability for essential oil quality control.
Luigi Mondello and leading lights from the organizing team spoke with LCGC International about the return of the 44th International Symposium on Capillary Chromatography (ISCC) and the 21st GC×GC Symposium, to be held May 17–22, 2026, at the Conference Centre in Riva del Garda, Italy, and why this is an essential event for the global separation science community.
Restek Corporation has launched its next-generation RMX gas chromatography (GC) columns incorporating a new TriMax deactivation technology onto the market.
Researchers evaluated the antibacterial activity of shiitake mushroom extracts prepared with different solvents and characterized their bioactive constituents using gas chromatography–mass spectrometry (GC–MS). Ethyl acetate extracts showed the strongest antibacterial effects against multiple pathogens, while chromatographic analysis identified ergosterol and linoleic acid as key antimicrobial contributors.
In a valproic acid–induced autism rat model, voluntary exercise improved social and cognitive behaviors by reshaping gut microbiota and metabolic signaling. Gas chromatography (GC) and liquid chromatography-mass spectrometry (LC–MS)–based chromatographic analyses revealed exercise-driven changes in short-chain fatty acids and neurotransmitters, with fecal microbiota transplantation reproducing these behavioral and metabolic benefits.
Researchers validated a sensitive and specific liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for simultaneous quantification of 6-MP, 6-TG, and 6-MMP in red blood cells. Demonstrating excellent linearity, accuracy, and precision, the approach supports routine therapeutic drug monitoring and advances personalized thiopurine therapy.
The second edition of the Green Analytical Chemistry Workshop promises to be an important event to promote sustainable analytical sciences. Initially launched in 2011 as the International SBSE Workshop, this biennial gathering has evolved significantly, broadening its scope and establishing itself as a key platform within the international scientific community.
Researchers from the Department of Chemistry at Michigan State University (East Lansing, Michigan) report that they have developed a label-free quantitative native proteomics workflow using native capillary zone electrophoresis–mass spectrometry (nCZE-MS) to profile endogenous protein assemblies, or complexoforms, in a complex biological sample. LCGC International spoke to the resulting paper’s authors, Fei Fang and Liangliang Sun, about this work.
Top articles published this week include several video interviews with key opinion leaders about the state of chromatography in 2026.
Researchers investigated grape stem extracts as a sustainable source of bioactive phenolic compounds, combining ultraviolet–visible spectrophotometry and high-performance liquid chromatography (HPLC) with antioxidant activity assessment, demonstrating that the stems, typically discarded during winemaking, can be effectively used to design and optimize functional products with enhanced antioxidant capacity
Susanne Boye discusses the future of chromatography, with a particular focus on FFF.
The Chromatographic Society has announced the winners of the Martin Medal and the Silver Jubilee Medal for 2026. Professor Guowang Xu of the Dalian Institute of Chemical Physics in China, has been awarded the Martin Medal, and the Silver Jubilee Medal has been awarded to Professor Bo Zhang of Xiamen University in China.
Researchers used liquid chromatography–mass spectrometry (LC-MS) to characterize changes in plasma and tissue amino acids in rat models of high-fat and high-sugar diets, high salt intake, and genetic or induced hypertension, revealing distinct and tissue-specific metabolic signatures.
A recent study analyzed 76 soy sauces with the Chinese liquor baijiu as a base aged from 2010 to 2024 using gas chromatography–mass spectrometry (GC-MS), identifying systematic aging trends in 77 volatile compounds, with esters generally decreasing and acids and alcohols increasing over time.
Bingchuan Wei discusses the latest trends in chromatography.
In a recent study, researchers compared five dry-processing fermentation methods for natural coffees, using ultra-high-pressure liquid chromatography (UHPLC), gas chromatography (GC), and high-performance liquid chromatography (HPLC) to link sugars, fatty acids, and chlorogenic acids with sensory outcomes.
LCGC International spoke to Lina Mikaliunaite, lead author of a recent paper presenting the first GC×GC–TOF-MS-based investigation of the pH-dependent volatome of M. pachydermatis, demonstrating the power of advanced multidimensional chromatography and chemometrics for resolving complex microbial VOC profiles.
Thomas Letzel discusses the latest trends in non-targeted screening and chromatography.
A new validated liquid chromatography–mass spectrometry (LC–MS) protocol for acrylamide (AA) detection in infant formula was developed using sequential hydration, acetonitrile (ACN) precipitation, and dual-sorbent clean-up, which minimized matrix effects and ensured clarity and high reproducibility.
Top articles published this week includes a deep dive into our chromatography industry survey results. and an exploration on the evolution of peptide science and modern technology.
Brett Paull explores the latest trends in chromatography, with a focus on portable LC instruments and miniaturization.
Dave Bell explores the latest trends in chromatography, with a focus on miniaturization and green technologies.
Researchers identified two novel selenium-containing peptides from selenium-enriched oysters that strongly inhibit ACE, improve vascular function, and outperform captopril in vitro, highlighting their promise as natural antihypertensive ingredients.
Tony Edge explores 2026 trends in chromatography, highlighting the impact of AI and automation on the industry.
Velaris has acquired Markes International from Schauenburg International, strengthening its automated sample preparation portfolio, expanding its global presence, and enhancing support for laboratories across multiple end markets.
