All News

Using pyrolysis gas chromatography-mass spectrometry (Py-GC–MS) to measure micro- and nanoplastic levels in blood, researchers found that higher exposure in young adults was associated with increased immune cell activation but showed no link to lung function.

Bingchuan Wei identifies the toughest unresolved analytical challenges in ADC development and highlights the emerging technologies he sees as most capable of closing those gaps.

Chromatography’s future depends on inclusive leadership, mentorship, communication, and human skills alongside technical expertise.

Using ultrahigh-performance liquid chromatography–mass spectrometry (UHPLC–MS) analysis, researchers quantified choline and betaine levels in maternal and cord blood and found that higher betaine exposure during pregnancy was associated with lower birthweight and reduced risk of excessive fetal growth.

Using gas chromatography-mass spectrometry (GC–MS) and gas chromatography with flame ionization detection (GC-FID), researchers identified carvone and limonene as the dominant compounds in caraway essential oil and showed that chitosan nanoparticle formulations improved microbial stability, reduced oxidation, and maintained the sensory quality of refrigerated pork sausages.

Bingchuan Wei of Genentech explains how HIC-MS integrates separation and mass detection to resolve and quantify individual DAR species with greater precision than standalone HIC or MS alone.

Using ultra high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS/MS), researchers characterized pressurized liquid extracts of artichoke by-products and identified a diverse range of phenolic and flavonoid compounds, including caffeoylquinic acid derivatives, obtained through a greener extraction approach.

Velaris unites major laboratory automation brands to advance chromatography and analytical workflows.

LCGC International spoke to David Bishop of the University of Technology Sydney about a new ruthenium-based tyramide amplification tag that combines fluorescence imaging with mass spectrometry imaging to improve detection and quantification of low-abundance proteins in tissue samples.

The week’s highlights include a four-part interview with Koen Vanhoutte of Johnson & Johnson Innovative Medicine on building more sustainable and efficient analytical laboratories, alongside stories on self-optimizing LC workflows, chromatography-based orange juice debittering, pesticide transformation during apple digestion, LC–MS/MS vitamin D profiling in breast cancer patients, and approaches for monitoring microbial spoilage in refrigerated meat.

Gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) analyses demonstrate that walnut septum extracts exhibit habitat-dependent compositional variability in amino acids and phenolics, which correlates with differences in antimicrobial activity against Gram-positive and Gram-negative bacteria.

Koen Vanhoutte of Johnson & Johnson Innovative Medicine concludes his four-part interview with his opinions on what the shift from routine testing to model‑based analytical science means in in practical terms for today’s analytical laboratories.

Advanced gas chromatography analysis reveals that palladium-based catalysts effectively reduce chlorine in polyvinyl chloride (PVC)-derived pyrolysis oil, improving its suitability for cleaner fuel applications.

An optimized ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method with tailored sample preparation enables accurate simultaneous detection of 30 PFAS compounds in seawater, sediment, and suspended particles, revealing their distribution and variability across marine environments.

In‑silico tools like retention‑time prediction are gaining attention. Koen Vanhoutte of Johnson & Johnson Innovative Medicine discusses how chromatographers should use these tools effectively without losing confidence in experimental data.

"Peak to Plate: Expert Insights in Food Analysis" explores how chromatography and mass spectrometry help experts detect contaminants, verify authenticity, and advance food analysis.

Gas chromatography (GC) of collected surgical emissions shows that a simple closed-circuit transurethral resection (TUR) system can reduce exposure to harmful smoke compounds during prostate surgery.

Using headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) and solid phase microextraction-GC-mass spectrometry (SPME-GC-MS) coupled with multivariate modelling, researchers correlated meat volatile profiles with microbial counts to enable rapid, chromatography-based assessment of spoilage and shelf-life.

As NIR and chemometric models rely heavily on chromatographic reference data, Koen Vanhoutte discusses the implications for the future role and expectations of chromatography in analytical science.

Researchers used liquid chromatography–mass spectrometry (LC–MS) to analyze hormone profiles in elite athletes, finding that some athletes with XY differences in sex development (DSD) showed testosterone patterns more similar to male athletes, helping improve understanding of conditions such as androgen insensitivity syndrome and 5α-reductase type 2 deficiency in competitive sports.

Using chromatography–mass spectrometry with ultrasound- and enzyme-based extraction methods, researchers showed that selenium speciation and recovery in broccoli sprouts depend on the extraction approach, providing insight into plant selenium uptake and metabolism relevant to food biofortification.

The 55th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2026) conference will take place from June 6–11, 2026, in Indianapolis, Indiana. Conference Chairs, Todd Maloney from Eli Lilly and Company and Jared Anderson from Iowa State University, highlight what the conference has to offer the chromatography community.

In the first of a four-part interview conducted at analytica 2026, Koen Vanhoutte of Johnson & Johnson Innovative Medicine discusses how self‑optimizing LC workflows are changing the way chromatographic methods are developed compared with traditional trial‑and‑error approaches.

Using liquid chromatography-tandem mass spectrometry (LC–MS/MS) to measure pre-treatment vitamin D levels, researchers found that low vitamin D is associated with a higher risk of severe paclitaxel-induced nerve damage in breast cancer patients.

Element Lab Solutions was officially rebranded as Crawford Scientific on 1st May 2026.

Using high-performance liquid chromatography-mass spectrometry (HPLC–MS) alongside bioassays and microbiota analysis, research has shown that gastrointestinal digestion alters the chemical fate, bioaccessibility, and toxicity of pesticides in apples in a compound-dependent manner.

A chromatography-based, non-heat process removes bitterness from orange juice while preserving its flavor and nutrients. LCGC International spoke to Araceli Rivera‑Pérez, lead author of the paper that resulted from its development.

Using thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS), researchers identified hundreds of wildfire smoke chemicals trapped in firefighter respirator filters and carbon cartridges, including several toxic compounds, highlighting the need for improved respiratory protection design.