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In this study, we applied a high-sensitivity MAPPs workflow using magnetic bead-based HLA-DR/DP/DQ immunoprecipitation and high-resolution mass spectrometry (HRMS) to assess the immunogenicity risk of six marketed mAbs across a panel of 10 HLA-typed donors.

The first analytica USA will take place from September 10–12, in Columbus, Ohio

In this installment, we explore the key relationships between efficiency and mobile phase flow rate and particle size, as well as secondary determinants of efficiency, including analyte retention, size, and chemistry, and instrumental effects.

This week, LCGC International published a variety of articles on hot topics in separation science. From a feature article on how to improve productivity in the laboratory to spotlighting some of the latest research in forensic analysis, we remain dedicated to sharing the latest in chromatographic advancements. Below, we’ve highlighted some of the most popular articles that were published this week.

Here, we provide a compilation of some of the rising stars of separation science, detailing their ongoing contributions to the industry.

Researchers from the U.S. Horticultural Research Laboratory’s Agricultural Research Service present a preliminary characterization of the citrus peel materials responsible for elevated high performance liquid chromatography-ultraviolet (HPLC-UV) chromatogram baselines from citrus peel extracts using Fourier-transform infrared (FTIR) and proton-nuclear magnetic resonance (1H-NMR) spectroscopy.

For the first time in the United States, Analytica brings leading exhibitors, research insights, and interactive lab technology showcases to Columbus, connecting professionals across the entire laboratory value chain.

Researchers at the Dalian Institute of Chemical Physics at the Chinese Academy of Sciences, have developed a rapid FastGC-PICI-TOFMS method that detects the carcinogenic compound ethyl carbamate in Chinese liquor in under four minutes.

In the race to do more, researchers risk sacrificing the deep thinking and collaboration that fuel true innovation.

Reacting to the frequency of vitamin D deficiency (VDD) among women, particularly those with central adiposity, a recent study by the American University of Madaba (Amman, Jordan) examined the predictors of vitamin D levels, focusing on age, adiposity, and muscle composition. Vitamin D levels were measured using high performance liquid chromatography (HPLC).

A panel of experts discusses the evolving analytical strategies and technical challenges of detecting per- and polyfluoroalkyl substances (PFAS), highlighting advances in mass spectrometry (MS), sample preparation, and untargeted analysis across environmental and food safety contexts.

Researchers at the University of Reading (United Kingdom) explored the potential of volatile organic compounds (VOCs) as markers for drought stress in potato plants using thermal desorption collection and gas chromatography mass spectrometry (GC-MS) with chemometric techniques.

This study reports a validated rapid, low-volume LC–MS/MS method capable of simultaneously quantifying remifentanil, etomidate, and rocuronium across a wide concentration range.

LCGC International spoke to Pablo Mohaupt, who, along with Marie-Laure Pons and their colleagues at the Clinical Proteomics Platform of Montpellier (Montpellier, France) and Shimadzu Corporation (Duisburg, Germany) developed a mass spectrometry (MS)-based method to measure α-synuclein peptides in plasma, aiming to identify disease-specific biochemical signatures that could support earlier and more precise diagnosis of α-synucleinopathies.

In a joint study conducted by Harbin University of Commerce and Northeast Agricultural University, gas chromatography-mass spectrometry (GC–MS) was used to investigate the volatile compounds profiles and quality changes of soybean-based meat analogue under 4 °C and -18 °C storage conditions.

In this article, you’ll find some of the top content that was published on LCGC this week, including calls for new chromatography technologies and interviews with rising stars in the field.

Can thyme reduce inflammation caused by rheumatoid arthritis? Researchers at Koya University (Koya, Iran) used gas chromatography-mass spectrometry to find out.

Evelyn Rampler of the Department of Analytical Chemistry at the University of Vienna discusses how her team developed a robust LC–MS/MS platform for semiquantitative glycosphingolipidomics in barley, enabling detailed structural annotation of GIPCs across developmental stages and stress conditions, and paving the way for comparative analyses across plant species.

Submit your latest chromatography products—including HPLC, GC, columns, and software—for inclusion in our upcoming new products article.

Research conducted at the Central University of Venezuela (Caracas, Venezuela) resulted in the development of a robust, definite, and economical methodology for rapid and accurate quantification of theobromine and caffeine in cocoa beans extracts from Venezuelan cocoa.

LCGC International spoke to Evelyn Rampler of the Department of Analytical Chemistry at the University of Vienna about the insights yielded regarding the role of glycosphingolipids in plant physiology and environmental resilience.

In this article, you’ll find some of the top content that was published on LCGC this week, including our upcoming forensic science content series and an interview on preanalytical factors for ethanol testing.

In research performed at the Beijing Technology and Business University (China), the aroma compounds of duck broth stewed from seven parts were characterized by headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) and gas chromatography-ion mobility spectrometry (GC-IMS).

During National Forensic Science Week, on September 15, LCGC International will release a one-day online series titled, “From Sample to Verdict.” This series will spotlight how chromatography is contributing to the advancement of forensic analysis, and how innovation in analytical science is improving law enforcement and investigative practices in the modern era.

Researchers investigated the impact of HCO3 in water on the aroma of brewed tea infusions using sensory evaluation, headspace solid-phase microextraction, and gas chromatography-mass spectrometry (GC-MS) techniques

Researchers in Egypt aimed to develop an efficient in vitro regeneration system for a local stevia genotype using callus induction, as well as both direct and indirect micropropagation and to assess its impact on steviol glycoside accumulation by comparison with conventionally soil-grown plant.

During ASMS 2025, LCGC International covered the most notable news from corporate and individual attendees, highlighting the latest advancements in mass spectrometry.