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Researchers evaluated the associations between serum lipidomic profile and subclinical carotid atherosclerosis (SCA) in type 1 (T1D) and type 2 (T2D) diabetes, as well as in non-diabetic controls. Lipidomic analysis was conducted using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) to identify specific lipid species linked to the presence and severity of SCA across the three groups.

In part 5 of this interview, Ralph Mead and his group at the University of North Carolina, Wilmington talk about climate change and how it impacts carbon fluxes, describing the role of PFAS in these environments.

Shimadzu Corporation named as a Nadeshiko Brand for advancing gender equality in the workplace.

Research conducted by the Universitas Padjadjaran (Sumedang, Indonesia) focused on the measurement of vitamin K1 in various vegetables (specifically lettuce, cabbage, napa cabbage, and spinach) that were ingested by patients using warfarin. High performance liquid chromatography (HPLC) equipped with an ultraviolet detector set at 245 nm was used as the analytical technique.

In the below video segment, we asked Ralph Mead and his team at the University of North Carolina, Wilmington, about the information gaps in understanding the transport of PFAS.

Oliver Jones and Navneet Singh from RMIT University, Melbourne, Australia discuss a recent study they conducted to investigate the relationship between tidal cycles and PFAS concentrations in estuarine systems, and offer practical advice on the sample preparation and LC–MS/MS techniques they used to achieve the best results.

Researchers conducted a study on medications used in psychiatry and neurology during the perinatal period, assessing how antiepileptic drugs (AEDs) affect placental functions, including transport mechanisms, nutrient transport, and trophoblast differentiation. Several quantitative methods, such as those for antianxiety and hypnotic drugs, were established to evaluate the safety of pharmacotherapy during breastfeeding using liquid chromatography-tandem mass spectrometry (LC–MS/MS).

University of Maribor scientists reviewed the techniques used to determine e-liquid and aerosol composition in electronic cigarettes.

Denise Bell, LabVantage Solutions Inc., describes how to utilize an integrated platform of lab informatics solutions to improve laboratory workflows.

In part three of this interview, they discussed the interactions between bacterial communities and replacement PFAS materials. Here's part three of our conversation with the Mead Group at UNC Wilmington.

Click here to access the LCGC International April 2025 Europe PDF in an interactive format.

Click here to access the LCGC International April 2025 North America PDF in an interactive format.

Researchers from the Department of Chemistry at Western Illinois University (Macomb, Illinois) conducted a study to optimize the separation of 18 cannabinoids for potency testing of hemp-based products, using liquid chromatography with a diode array detector (LC–DAD). As part of our monthlong series of articles pertaining to National Cannabis Awareness Month, LCGC International spoke to Liguo Song, the corresponding author of the paper stemming from this research, to discuss the study and its findings.

Protecting your network chromatography data system (CDS) data is critical and a service level agreement (SLA) with your IT provider is vital. What should be included? Are SLAs for in-house IT and SaaS (software as a service) similar?

LCGC International spoke to Lauren Lovejoy, principal scientist in the Drug Substance and Product Analysis group at GSK (Philadelphia, Pennsylvania), about the advantages of using tandem columns in sequential elution liquid chromatography (SE-LC) to investigate weak acids, neutral compounds, and permanent anions in pharmaceutical applications.

In this installment, we will review the fundamental terminology and data analysis principles in benchtop GC–MS. We will compare the three modes of analysis—full scan, extracted ion chromatograms, and selected ion monitoring—and see how each is used for quantitative and quantitative analysis.

In part 2, Ralph Mead and his team explain the challenges of characterizing and quantifying PFAS in environmental samples.

Here is some of the most popular content posted on LCGC International this week.

The Mead Group at UNC Wilmington studies the occurrence and transport PFAS in wet and dry depositions, tracing their sources to inform regulators. In the first part of our interview, we spoke with Mead and several members of his team about the work they do for the North Carolina PFAS Testing Network and learn more about the network.

Researchers attempted to ascertain the relationship between vitamin D levels in athletes and the structural and functional values of their hearts assessed through electrocardiographic and echocardiographic parameters. Vitamin D levels were measured using high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS).

Frankincense essential oil is known for its anti-inflammatory, antioxidant, and therapeutic properties. A recent study investigated the protective effects of the oil in an excision wound model in rats, focusing on oxidative stress reduction, inflammatory cytokine modulation, and caspase-3 regulation; chemical composition of the oil was analyzed using gas chromatography–mass spectrometry (GC–MS).

A study in Food Science & Nutrition evaluated the antioxidant and preservative effects of Epilobium angustifolium extract on beef burgers, finding that the extract influenced physicochemical properties, color stability, and lipid oxidation, with higher concentrations showing a prooxidant effect.

Microplastics and nanoplastics have been identified in the lungs of wild birds using laser direct infrared (LDIR) chemical imaging and pyrolysis gas chromatography–mass spectrometry (Py-GC–MS), in the first multi-species evidence of these plastics in bird lungs.

To honor the conclusion of Women's History Month, we took time to talk with various leading members of Females in Mass Spectrometry (FeMS) about the importance of this month and their time with FeMS.

As part of our Women's History Month coverage, we talked with Iulia Macavei of Evosep about her PhD thesis on mass spectrometry-based proteomics and her role in the Fundrasing Committee for Females in Mass Spectrometry (FeMS).

Iowa State University researchers evaluated imidazolium-based ZILs with sulfonate and triflimide anions to understand the influence of ZILs’ chemical structures on polar analyte separation.

David Megson from Manchester Metropolitan University in Manchester, UK, spoke to LCGC International about the latest developments in non-targeted analysis (NTA) of per- and polyfluoroalkyl substances (PFAS) in environmental matrices based on a recent systematic review paper he has collaboratively published (1).

The conference will return to its original home in Pittsburgh, after the inaugural event was held at the William Penn Hotel in the city in 1950.

Cinnamon and its byproducts have been used for many years because of their antidiabetic effect. In a joint study conducted by Gazi University (Ankara, Turkey) and Düzce University (Düzce, Turkey), high performance liquid chromatographic (HPLC) and thin-layer chromatography (TLC) analyses, macroscopic analyses, and enzyme inhibition assays on diabetes-related enzymes were performed on cinnamon samples to determine whether they are safe to use for health purposes.

As the organic tea industry grows, verifying its authenticity is essential for maintaining market stability. A recent study proposed a model for distinguishing organic tea from conventional varieties, with components (water extract, polyphenols, mineral element) of each type compared through high performance liquid chromatography (HPLC), inductively coupled plasma–mass spectrometry (ICP-MS), and mass spectrometry (MS) analysis.