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A concise summary and celebration of the role of sample preparation for quantitative analysis in bioanalytical applications.

LCGC International spoke to Szabolcs Fekete of Waters Corporation, corresponding author of a recent paper which introduces and validates a novel separation quality factor (SQF) metric, designed to overcome the limitations of existing performance descriptors by integrating multiple normalized and weighted criteria into a single score.

Researchers from the University of Campinas (Campinas, Brazil) and the Waters Research Center (Budapest, Hungary) introduced a rapid, automated method using laser-assisted rapid evaporative ionization mass spectrometry (LA-REIMS) with high-resolution mass spectrometry to fingerprint coffee samples and predict sensory properties. LCGC International spoke to Leandro Wang Hantao of the University of Campinas regarding their work and the paper that resulted from it.

Caitlin Cain shares insights from the Lindau Nobel Laureate Meeting, exploring AI's role in chemistry, sustainability innovations, and the importance of science advocacy.

In the third part of this roundtable discussion focused on the experiences, challenges, and contributions of Women in Chromatography, LCGC International spoke to Noor Abdulhussain, Lotte Schreuders, and Mimi den Uijl—co-founders of the Sisters in Science initiative—to ask what advice they would offer to young women aspiring to enter a STEM career.

This year marks the 40th anniversary of the Prep Conference—The International Symposium on Preparative and Process Chromatography. Prep 2025 will take place in Philadelphia, USA, next week from September 29 to October 2, 2025.

Researchers from institutions in Kenya used both morphological and molecular techniques for taxonomic identification, a disk diffusion method for bioassay analysis, and gas chromatography–mass spectrometry (GC-MS) to identify and quantify different compounds in the extracts of marine sponge samples.

The RGB model, which combines red (analytical performance), green (environmental impact), and blue (practicality), is at the heart of the concept of white analytical chemistry (WAC). While this approach has helped broaden the field’s focus and offered a more balanced evaluation system, analytical science continues to move forward, and with it come new priorities that extend beyond what the RGB framework can fully reflect. This final article of this week's series on WAC curated by Adrián Fuente-Ballesteros of the University of Valladolid (Spain) presents new tools intended to fill that gap.

This fourth article in a series curated by Adrián Fuente-Ballesteros of the Faculty of Sciences at the University of Valladolid (Spain) discusses the importance of the red dimension within the white analytical chemistry (WAC) framework, and presents the Red Analytical Performance Index (RAPI) tool as a critical advancement for harmonizing analytical performance assessment.

In the first part of this roundtable discussion focused on the experiences, challenges, and contributions of Women in Chromatography, LCGC International spoke to Noor Abdulhussain, Lotte Schreuders, and Mimi den Uijl—co-founders of the Sisters in Science initiative—about their movement, which was started in 2021.

Researchers in Malaysia examined the effects of Kelulut honey on metabolic syndrome (MetS)-induced osteoporosis in male rats fed a high-carbohydrate high-fat (HCHF) diet, with chemical profiling of the honey was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods.

This third in the series of five articles curated by Adrián Fuente-Ballesteros of the Faculty of Sciences at University of Valladolid (Spain)focuses on the blue dimension of white analytical chemistry (WAC), a concept introduced to complement green analytical chemistry (GAC) by incorporating analytical performance (red) and practical and economic aspects (blue).

LCGC International spoke to the author of the study, John Mommers, who is a scientist of chromatography and mass spectrometry (MS) at Envalior, about the key challenges faced when developing MASSISTANT and how it can be integrated in GC-EI-MS workflows.

Green analytical chemistry (GAC) has emerged as a critical discipline focused on minimizing the environmental footprint of analytical methods. This second article in this week's series curated by Adrián Fuente-Ballesteros of the Faculty of Sciences at University of Valladolid (Spain) traces the evolution of GAC through the development of its key greenness assessment metrics.

LCGC International spoke with Giorgia Purcaro, Ilaria Belluomo, and Katelyn Perrault Uptmor on advancing equity in chromatography, highlighting cultural shifts, practical strategies, and resources to support DEI success and leadership.

LCGC International spoke to Maria Hayder, corresponding author of a recently published paper (1) discussing a novel workflow for nanoplastic analysis in environmental water samples, incorporating asymmetrical-flow field-flow fractionation coupled with multiangle light scattering (AF4-MALS) and pyrolysis–gas chromatography-mass spectrometry (Py-GC-MS) in an offline combination.

A recent study examined a new method to optimize raisin production by demonstrating how pretreating grapes with extra-virgin olive oil (EVOO) before dehydration can significantly improve the retention of beneficial phenolic compounds during raisin production and storage.

A recent roundtable with Giorgia Purcaro, Ilaria Belluomo, and Katelyn Perrault Uptmor explored challenges and opportunities for women in chromatography, sharing personal journeys, career barriers, and advice for future separation scientists.

Researchers at the Université de Montréal evaluating the pharmacokinetics and pharmacodynamics of a single oral dose of trazodone in laboratory rabbits determined plasma concentrations of the drug with high performance liquid chromatography-mass spectrometry (HPLC-MS).

This week, LCGC International published a variety of articles on hot topics in separation science. From several interviews around the role chromatography is playing in forensic analysis to using multidimensional liquid chromatography (LC) in the development of a new Python tool, we’ve highlighted some of the most popular articles that were published this week.

Researchers at the University of Johannesburg investigated the potential of orotate phosphoribosyl transferase (URA5) to detoxify patulin in apple juice under controlled condition, with liquid chromatography-mass spectrometry (LC-MS) used to monitor degradation.

Discover how to optimize LC×LC orthogonality for organic micropollutants analysis, enhancing method development with a new open-source Python tool.

As part of “From Sample to Verdict,” LCGC International sat down with Noemi Procopio, who is the Principal Investigator of the "Forens-OMICS" team and a Senior Research Fellow in Forensic Science at the University of Central Lancashire to talk about her team’s work. In Part III of our conversation with Procopio, she discussed how her team analyzes bone samples for post-mortem interval (PMI) estimation. In the final part of our conversation, Procopio discusses what a routine omics-based PMI assay could look like in the future.

Researchers used orthogonal analytical methods, including anion-exchange chromatography (AEC), to investigate the impact of successive freeze/thawing cycles on the stability of the Covid vaccine ChAdOx1-S/nCoV-19.