Researchers developed a solid phase extraction liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method enabling sensitive chromatographic separation and quantification of eight steroid hormones in ≤50 mg whale blubber. The approach achieved low detection limits, reliable measurements across species, and supports conservation by assessing stress, metabolism, and reproductive status from minimal sample material.
Liquid chromatography–mass spectrometry (LC-MS) was used to evaluate the stability of ethanol-free buprenorphine formulations in compounded oral syringes over 60 days. Chromatographic analysis showed no degradation products and consistent drug concentrations, supporting formulation stability and safety while highlighting the role of LC–MS in pediatric pharmaceutical quality assessment.
Sébastien Rolle explores the practical barriers preventing wider adoption of SFE and SFC, and what instrument manufacturers can do to lower them.
Researchers used high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to demonstrate that atmospheric cold plasma (ACP) effectively removes up to 82.5% of toxic fenvalerate residues from shiitake mushrooms. The study identified degradation pathways like hydroxylation and ester bond cleavage. ACP offers a promising, non-thermal solution to enhance food safety and preserve mushroom quality during storage.
Sébastien Rolle discusses the trade-offs between greener instrument design and analytical performance, addressing sensitivity, throughput, and method robustness for laboratory scientists.
Submit your latest chromatography products—including HPLC, GC, columns, and software—for inclusion in our upcoming new products article.
Researchers developed an advanced gas chromatography approach that allows direct analysis of recycled plastics with minimal preparation. This method uses thermal desorption to efficiently detect volatile contaminants, making it faster and more practical for routine quality control.
High-performance liquid chromatography (HPLC) was utilized by researchers to measure plasma hydrogen sulfide (H₂S) in patients with schizophrenia. The study revealed that after antipsychotic treatment, elevated H₂S levels—accurately determined via HPLC—correlated significantly with improved memory, highlighting H₂S signaling as a key factor in understanding cognitive impairment.
With open access to GreenSOL, Elia Psillakis describes how laboratories are adopting it in practice.
The first assessment of deuterated solvents reveals significant, often overlooked environmental burdens tied to essential analytical reagents.
Researchers used tandem mass tagged quantitative liquid chromatography tandem mass spectrometry (TMT-LC-MS/MS) to analyze plasma from exposed loggerhead and Kemp's ridley turtles, identifying altered immune proteins as biomarkers for brevetoxicosis, aiding diagnosis amid intensifying blooms.
Dr Victoria Samanidou from the School of Chemistry at the Aristotle University of Thessaloniki, Greece, gives a detailed overview of applying green metrics tools in the "real world."
As we celebrate Earth Day 2026, LCGC revisits the archives and looks back at the content that remains as relevant as ever.
Natalia Manousi from TU Wien, Austria, describes the value of combining the Blue Applicability Grade Index (BAGI) with established metrics to develop methods that are reliable, efficient, and suitable for "real-world" applications.
Elia Psillakis challenges the assumption that bio-based solvents are always greener, urging labs to adopt evidence based choices over simple origin claims.
Elia Psillakis discusses how a life cycle view of solvents exposes unexpected impacts in chemicals long considered safe, challenging entrenched ideas of greenness in analytical labs.
LCGC's "Earth Day" coverage examines a advanced mass spectrometry method to accurately measure PFAS and trace pharmaceuticals in wastewater.
Our "Earth Day" coverage continues with a look at how LC-HR-MS/MS can track how human-made chemical pollution is harming ocean ecosystems.
Our "Earth Day" coverage examines a study using fluorinated ionic liquid stationary phases to analyze forever chemicals.
Drug testing of non-biological samples revealed a new nitazene opioid, N-pyrrolidino fluetonitazene, in a nasal spray. Researchers used gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) alongside other methods to confirm its identity. The finding highlights evolving drug trends, serious health risks, and the need for up-to-date analytical techniques despite limited sample size.
Andrea Hochegger from Graz University of Technology, Austria describes the benefits that comprehensive two-dimensional GC (GC×GC–MS) offers over conventional GC–MS to resolve complex mixtures from recycled packaging materials. Andrea will present on this topic at Extech 2026, which will take place at the University of Liege, Gembloux, Belgium from July 6–9 2026.
Liquid chromatography–mass spectrometry (LC-MS) enabled comprehensive profiling of metabolites produced by cucumber glandular trichomes across developmental stages. Analysis identified 744 compounds, dominated by flavonoids, and revealed ecotype-specific variations. Chromatographic insights into trichome secretions link metabolite composition to fruit bloom formation and support future crop improvement and natural product applications.
Sébastien Rolle examines four levels of manufacturer sustainability impact and questions whether the analytical chemistry industry is moving fast enough across all fronts.
Ion chromatography and 16S rRNA sequencing were applied to evaluate seasonal nutrient removal and microbial dynamics in an A2O wastewater treatment plant. Results showed temperature-dependent nitrifier reductions impacting efficiency, while downstream monitoring revealed transient microbial influence on river systems, highlighting chromatography’s role in linking nutrient chemistry with ecological outcomes.
The 28th International Symposium on Advances in Extraction Technologies (ExTech 2026) will take place on July 6–9 2026 in the historic town of Gembloux, Belgium.
A research study recently introduced a streamlined, chromatography-compatible workflow for the rapid analysis of RNA modifications by integrating solid-phase enzymatic digestion with downstream liquid chromatography–mass spectrometry (LC–MS). LCGC International spoke to Yixuan (Axe) Xie, an assistant professor at Fudan University (Shanghai, China) and one of the authors of a paper resulting from this study.
Gauthier Eppe discusses the vast data complexity that arises when ion mobility is layered on top of HRMS in non-targeted contaminant screening workflows.
Researchers explored the potential of Prunus laurocerasus (cherry laurel) and Prunus cerasifera (cherry plum) fruit pits as natural food additives. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed that the extracts were found safe for healthy cells, selectively targeted certain cancer cells, and showed strong antioxidant and enzyme-inhibiting activities, including anti-browning effects. These findings highlight the pits’ promise as sustainable, functional food ingredients.
This week on ChromatographyOnline.com, we highlight sustainable sample preparation alongside the transformative impact of AI and machine learning in chemical analysis, and explore advanced methodologies like ion mobility-HRMS and HPLC for tackling complex real-world challenges.
A study identified invasive Burmese pythons as effective biological sentinels for monitoring chemical pollution in the Florida Everglades. Researchers analyzed liver samples from 67 pythons using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to track 30 per- and polyfluoroalkyl substances (PFAS).
