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Michael Bartlett, Torgny Fornstedt and Mark Dickman conclude the series with their expert insights into what the future of oligonucleotide analysis could involve.

The panel discuss the innovations in sample preparation that are being developed for oligonucleotide analysis.

The sensitivity and selectivity of high resolution mass spectrometry (HRMS) for oligonucleotide analysis is discussed.

Researchers used GC-IMS technology to analyze the volatile flavor compounds in different plum varieties and the changes in flavor during the salting process.

Key aspects involved in manufacturing high-quality packed capillary columns, including fritting, column packing, and parallel fabrication, are discussed.

In this second part of a series on fundamentals of HPLC for practicing scientists, LCGC International column editor Michael W. Dong discusses the benefits and limitations of the technique.

Mark Dickman shares his views on analyzing larger oligonucleotides, including mRNAS.

A study to illustrate the metabolic changes in the adipose tissue metabolome of Holstein dairy cows transitioning from one lactation cycle to the next integrated liquid chromatography, flow injection, and electrospray ionization triple quadrupole MS.

The panel explore the potential of multidimensional chromatography for the analysis of oligonucleotides.

“Perspectives in HPLC” column editor Michael Dong presents a brief history of the technique as part of his 26-episode video series, “HPLC for Practicing Scientists - Fundamentals."

The panel discuss the role of ion-exchange chromatography (IEX) and hydrophilic interaction liquid chromatography IHILIC) in oligonucleotide analysis, and if these techniques could challenge ion-pair reversed-phase high performance liquid chromatography (IP-RP-HPLC) in the near future.

A joint study by India’s Mohanlal Sukhadia University and the Central University of Punjab identified fungal pathogens linked to ginger rhizome rot and analyzed their effects and mycotoxins using molecular and chromatographic techniques.

How does liquid chromatography (LC) assist in forensic analysis?

A global team led by Michal Holčapek, professor of analytical chemistry at the Faculty of Chemical Technology, UPCE, Pardubice (Czech Republic), and Jakub Idkowiak, a research associate from KU Leuven (Belgium), has unveiled a powerful R and Python-based toolkit for tackling the complexities of lipidomics and metabolomics data, offering researchers a new approach for “omics” analysis.

A recent study examined single-particle inductively coupled plasma time-of-flight mass spectrometry (SP-ICP-TOF-MS) as a novel technique for uranium particle isotope ratio measurements.LCGC International spoke to Benjamin Manard, Senior R&D Staff Scientist and the Group Leader of the Chemical & Isotopic Mass Spectrometry Group at Oak Ridge National Laboratory (ORNL) as well as to Sarah Szakas and Jordan Stanberry, postdoctoral researchers at ORNL, three of the authors of the paper that resulted from this study.

The role of gas chromatography (GC) in forensic analysis is spotlighted.

This week, LCGC International published a variety of articles on hot topics in separation science. From an interview about the evolution of ion chromatography to a discussion about using ultrahigh-pressure liquid chromatography (UHPLC) coupled with tandem mass spectrometry (MS) to analyze 26 per- and polyfluoroalkyl substances (PFAS), we’ve highlighted some of the most popular articles that were published this week.

Recognizing that the long-term fate of tire and road wear particles (TRWP) influences the distribution of tire-related chemicals, researchers at the Helmholtz Centre for Environmental Research analyzed 27 polar and moderately polar compounds by LC–MS, including para-phenylenediamines, phenylguanidines, benzothiazoles, and known transformation products.

We explore a core analytical question that every chromatographer faces: How many injections are really enough to achieve both scientific reliability and practical efficiency?

Knauer Wissenschaftliche Geräte GmbH has acquired Labomatic AG (Möhlin, Switzerland). The acquisition expands the Berlin, Germany scientific equipment manufacturer’s portfolio in preparative high-performance liquid chromatography (HPLC), particularly with HPLC systems designed for flow rates of up to 540 liters per hour.

A joint study conducted by United States Department of Agriculture and Pomona College developed a healthy, marketable juice by combining the nutritional benefits of noni fruit juice with the palatability of pineapple juice and then evaluating the physical, chemical, and sensory properties of the resulting blend.

A look at recent advances in pesticide residue analysis across diverse food matrices.

Researchers found that blood collection tubes from different manufacturers can interfere with LC-MS/MS measurement of serum 25-hydroxyvitamin D [25(OH)D], a critical preanalytical quality control issue affecting assay accuracy.

ACD/Labs and Covestro have launched an AI-powered solvent selection tool within the Percepta platform, giving chemists a new data-driven option to reduce environmental impact.

The development of a high-throughput LC–MS/MS method for quantifying 135 pesticides with improved accuracy and robustness is discussed.

Research conducted at the Federal University of Campina Grande developed an active pharmaceutical ingredient (API) derived from Psilocybe mushrooms for application in the management of mental health disorders.

Waters Corporation announced the Waters Xevo Charge Detection Mass Spectrometer for the measurement and characterization of mega-mass biomolecules central to next-generation therapeutics and structural biology.

A recent study details the development of an LC–MS/MS method for detecting pesticide residues in a challenging matrix, chili powder.