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Researchers developed and validated a LC–MS/MS method for the detection of antibacterial, antifungal, and antiparasitic residues in legume-based alternative protein products. LCGC International spoke to Awanwee Petchkongkaew and Chanita Boonkanon, corresponding and lead authors, respectively, of the paper outlining this work.

Supercritical CO₂ extraction of limoncello-derived lemon peels, followed by gas chromatography-mass spectrometry (GC–MS) analysis, revealed monoterpene-rich chemical profiles with antioxidant, antimicrobial, and skin-beneficial potential, supporting their value as sustainable cosmetic ingredients.

Fernando Lanças discusses miniaturized liquid sample preparation for greener LC–MS/MS workflows in environmental analysis, favoring SUPRAS and DES solvents.

HIC-MS, ADC characterization, career insights, and aroma and protein detection research highlight this week’s website offerings.

Using liquid chromatography–mass spectrometry (LC–MS), researchers compared arterial and venous oxylipin profiles in obese and non-obese heart failure with preserved ejection fraction (HFpEF) patients and identifies distinct obesity-associated lipid mediator patterns linked to more severe pulmonary hypertension.

Using liquid chromatography–mass spectrometry (LC-MS) and machine learning, researchers identified distinct steroid hormone patterns in chronic versus episodic cluster headache that may help differentiate disease subtypes and point to adrenal-related involvement.

Paweł Wiczling from the Medical University of Gdańsk, Poland describes some of the practical benefits that artificial intelligence/machine learning (AI/ML) can offer separation scientists. Pawel will present on this topic at Extech 2026, which will take place at the University of Liege, Gembloux, Belgium from July 6–9 2026.

Using gas chromatography–mass spectrometry (GC–MS), researchers compared volatile flavor compounds formed in chicken breast treated with free iron, heme iron, and hemoglobin, showing that each iron type alters fat oxidation pathways and resulting aroma profiles differently.

Bingchuan Wei discusses how robust ADC characterization strategies meet regulatory expectations and how stronger methodologies can accelerate candidate selection to clinical approval.

The 12th International Symposium on Recent Advances in Food Analysis (RAFA 2026) will take place in Prague, Czech Republic, from 3–6 November, 2026.

Using pyrolysis gas chromatography-mass spectrometry (Py-GC–MS) to measure micro- and nanoplastic levels in blood, researchers found that higher exposure in young adults was associated with increased immune cell activation but showed no link to lung function.

Bingchuan Wei identifies the toughest unresolved analytical challenges in ADC development and highlights the emerging technologies he sees as most capable of closing those gaps.

Chromatography’s future depends on inclusive leadership, mentorship, communication, and human skills alongside technical expertise.

Using ultrahigh-performance liquid chromatography–mass spectrometry (UHPLC–MS) analysis, researchers quantified choline and betaine levels in maternal and cord blood and found that higher betaine exposure during pregnancy was associated with lower birthweight and reduced risk of excessive fetal growth.

Using gas chromatography-mass spectrometry (GC–MS) and gas chromatography with flame ionization detection (GC-FID), researchers identified carvone and limonene as the dominant compounds in caraway essential oil and showed that chitosan nanoparticle formulations improved microbial stability, reduced oxidation, and maintained the sensory quality of refrigerated pork sausages.

Bingchuan Wei of Genentech explains how HIC-MS integrates separation and mass detection to resolve and quantify individual DAR species with greater precision than standalone HIC or MS alone.

Using ultra high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS/MS), researchers characterized pressurized liquid extracts of artichoke by-products and identified a diverse range of phenolic and flavonoid compounds, including caffeoylquinic acid derivatives, obtained through a greener extraction approach.

Velaris unites major laboratory automation brands to advance chromatography and analytical workflows.

LCGC International spoke to David Bishop of the University of Technology Sydney about a new ruthenium-based tyramide amplification tag that combines fluorescence imaging with mass spectrometry imaging to improve detection and quantification of low-abundance proteins in tissue samples.

A discussion on mentorship, industry gaps, and how confidence, exposure, and support shape careers in analytical science.

The week’s highlights include a four-part interview with Koen Vanhoutte of Johnson & Johnson Innovative Medicine on building more sustainable and efficient analytical laboratories, alongside stories on self-optimizing LC workflows, chromatography-based orange juice debittering, pesticide transformation during apple digestion, LC–MS/MS vitamin D profiling in breast cancer patients, and approaches for monitoring microbial spoilage in refrigerated meat.

Gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) analyses demonstrate that walnut septum extracts exhibit habitat-dependent compositional variability in amino acids and phenolics, which correlates with differences in antimicrobial activity against Gram-positive and Gram-negative bacteria.

Koen Vanhoutte of Johnson & Johnson Innovative Medicine concludes his four-part interview with his opinions on what the shift from routine testing to model‑based analytical science means in in practical terms for today’s analytical laboratories.

Advanced gas chromatography analysis reveals that palladium-based catalysts effectively reduce chlorine in polyvinyl chloride (PVC)-derived pyrolysis oil, improving its suitability for cleaner fuel applications.

An optimized ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method with tailored sample preparation enables accurate simultaneous detection of 30 PFAS compounds in seawater, sediment, and suspended particles, revealing their distribution and variability across marine environments.

In‑silico tools like retention‑time prediction are gaining attention. Koen Vanhoutte of Johnson & Johnson Innovative Medicine discusses how chromatographers should use these tools effectively without losing confidence in experimental data.

"Peak to Plate: Expert Insights in Food Analysis" explores how chromatography and mass spectrometry help experts detect contaminants, verify authenticity, and advance food analysis.

Gas chromatography (GC) of collected surgical emissions shows that a simple closed-circuit transurethral resection (TUR) system can reduce exposure to harmful smoke compounds during prostate surgery.