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In this sixth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor compares the chromatographic properties of acetonitrile and methanol.

A three-year study of medical students and doctors in training tracked burnout symptoms alongside inflammation markers and morning cortisol and cortisone levels in saliva, measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS), to better understand the biology of burnout.

Ed Ahearne combined automation, machine learning, and Bayesian optimization to speed up method development for siRNA medicines.

Data-independent acquisition (DIA) liquid chromatography-tandem mass spectrometry (LC–MS/MS) reveals shared and site-specific proteins across the thighbone.

Laura Righetti explains why quantification, not instrumentation, still keeps mass spectrometry imaging (MSI) out of routine food safety testing.

Large language models help chromatographers build LC pressure troubleshooting apps in hours.

Magnetic molecularly imprinted polymer extraction with liquid chromatography-high resolution mass spectrometry (LC–HRMS) finds patulin in store-bought juice.

Richard Bade and Malcolm McLeod explain to LCGC International how liquid chromatography-tandem mass spectrometry (LC-MS/MS) detects drug trends in wastewater.

In this fifth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses how to overcome challenges with reversed-phase chromatography in drug analysis.

Ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) shows Maresin1 drops in heatstroke and may protect the heart.

This week on Chromatography Online, leading experts shared practical insights with LCGC International on sustainable affinity methods, siRNA impurity profiling, nontarget screening, peptide tech transfer, and AI in separation science.

Liquid chromatography–mass spectrometry (LC–MS) was used to determine if there is a link between artificial sweeteners and breast cancer.

Chiral gas chromatography–mass spectrometry (GC–MS) shows how heat and storage alter linalool in blueberry juice.

Anneli Kruve reports that toxicity predictions from MS2-derived molecular fingerprints outperform spectral-similarity methods in non-target screening of food.

In this fourth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why buffers are most often used in Mobile Phase A in high-pressure liquid chromatography of pharmaceuticals.

Skipping solid-phase extraction (SPE) cleanup rarely hurt liquid chromatography–tandem mass spectrometry (LC–MS/MS) plant hormone results in tomato.

The panel considers how AI and automation could reshape peptide method development, and why scientific judgment will remain essential.

Gas chromatography–mass spectrometry (GC–MS) and docking reveal A. excelsa leaf compounds that may help in cancer treatment.

Gert Desmet offers his insights on the potential benefits AI/ML could offer the separation science community in the future.

Quantitative non-targeted screening with predicted response factors is not for regulation, but can rank environmental chemicals by concentration and toxicity.

Gert Desmet explores the current role of AI/ML in separation science.

Gas chromatography–mass spectrometry (GC–MS) reveals a four-stage polycyclic aromatic hydrocarbons (PAH) breakdown in oil sludge co-composted with manure.

This new high-performance liquid chromatography-ultraviolet (HPLC-UV) method measures glutathione and thiol levels across 12 berries.

Piotr Alvarez explains how HILIC complements reversed-phase LC for GLP-1 peptides, and why the field is moving toward MS-friendly TFA alternatives.

In this third part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses the retention mechanism of hydrophobic interaction.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) shows hydrogel cuts dogs' peak bupivacaine blood levels fivefold.

In the second part of our interview, Novartis's Martina Lioi talks about using IP-HILIC and RP for lipid-siRNA impurities

LCGC International spoke to David Hage, Sanduni Heenkenda, and Zoe Zingler of the University of Nebraska-Lincoln about how green chemistry principles are reshaping affinity chromatography.