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Ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) reveals a chemical imbalance behind alcohol-positive milk.

"Perspectives in HPLC" examines 5 long-held HPLC "rules" (mobile phase filtration, routine buffer use, avoiding pH near an analyte's pKa, defaulting to 4.6-mm columns, and relying on AI for early method development), showing with experimental evidence that each is conditional rather than universally true in modern small-molecule drug testing.

In this ninth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explores the reasons why mobile phase filtration is not needed.

A review of affinity chromatography methods for biopharmaceutical analysis.

Ultrahigh-performance liquid chromatography–ion mobility–quadrupole time-of-flight mass spectrometry (UHPLC–IM–QTOF MS) reveals seasonal chemical fingerprints in Scottish honey.

Markes International’s vacuum-assisted HiSorb extends analyte coverage for gas chromatography.

Gold-enhanced thin-layer chromatography–surface-enhanced Raman scattering (TLC–SERS) identifies toxic aromatics in firefighting water.

ChromSoc’s Data Analytics and AI in Chromatography symposium will debate whether AI could ever replace chromatographers, alongside pharma case studies.

Five years after its founding, the Hungarian developer of centrifugal partition chromatography is making the case that liquid–liquid separation belongs on the analytical bench as well as the production floor.

A two-dimensional gas chromatography (GC×GC) study of 43 volatiles shows hexanal alone cannot gauge hazelnut aging.

In this eighth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses why ultraviolet detection dominates pharmaceutical analysis and quality control.

High-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) was used in a reverse triiodothyronine (rT3) test to separate canine hypothyroidism from illness.

Quantera Analytical’s Terry Bates discusses parallel headspace extraction for gas chromatography-mass spectrometry (GC–MS) and direct analysis in real time–mass spectrometry (DART–MS) analysis.

Amandaa Brewer warns a shortage of large-molecule chromatography experts, as practitioners retire, could leave the next generation without the fundamentals.

Christopher Chouinard of Clemson University discusses with LCGC International how derivatization reshapes steroid mass for sharper liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS) separations.

PFAS, pyrolysis oils, new GC hardware, and AI in the laboratory led the program at the 2026 Gulf Coast Conference in Galveston, Texas.

Gas chromatography (GC) tests show spoilage yeasts alter flavor and raise alcohol in NoLo beer.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) finds low glyphosate residues of the weedkiller glyphosate in coffee beans.

This week, Chromatography Online explored how the technique is advancing wastewater drug monitoring, siRNA method development, and food safety testing, with previews of RAFA 2026 and a return to HPLC fundamentals with Michael Dong.

Recent EU legislation on PFAS shifts from monitoring individual compounds toward managing them as a chemical class.

In this seventh part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why 2.1-mm i.d. columns are less preferred for pharmaceutical quality control.

Ultrahigh-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) shows how soaking and cooking break down soybean fats.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) links altered metabolism to lingering symptoms in Ebola survivors.

Nicolai Zederkopff explores chromatography’s role to help implement the maximum tolerable level (MTL) framework for food adulteration to translate analytical results into compliance decisions.

Franz Berthiller (BOKU University, Austria) discusses a multilaboratory study that used retention index markers to align mycotoxin liquid chromatography–mass spectrometry (LC–MS) data.

A QuEChERS/ultrahigh-performance liquid chromatography and high-resolution mass spectrometry (UHPLC-HRMS) method tracks 23 plant toxins in cereals and spices. Michele Suman discusses the method with LCGC International.

Gas chromatography-mass spectrometry (GC-MS) study links 110 scent compounds to cinnamon variety and origin.

Affinity chromatography-purified viral protein powers a new FAdV-8b test for chickens.