In a recent study, researchers compared five dry-processing fermentation methods for natural coffees, using ultra-high-pressure liquid chromatography (UHPLC), gas chromatography (GC), and high-performance liquid chromatography (HPLC) to link sugars, fatty acids, and chlorogenic acids with sensory outcomes.
LCGC International spoke to Lina Mikaliunaite, lead author of a recent paper presenting the first GC×GC–TOF-MS-based investigation of the pH-dependent volatome of M. pachydermatis, demonstrating the power of advanced multidimensional chromatography and chemometrics for resolving complex microbial VOC profiles.
Thomas Letzel discusses the latest trends in non-targeted screening and chromatography.
A new validated liquid chromatography–mass spectrometry (LC–MS) protocol for acrylamide (AA) detection in infant formula was developed using sequential hydration, acetonitrile (ACN) precipitation, and dual-sorbent clean-up, which minimized matrix effects and ensured clarity and high reproducibility.
Top articles published this week includes a deep dive into our chromatography industry survey results. and an exploration on the evolution of peptide science and modern technology.
Brett Paull explores the latest trends in chromatography, with a focus on portable LC instruments and miniaturization.
Dave Bell explores the latest trends in chromatography, with a focus on miniaturization and green technologies.
Researchers identified two novel selenium-containing peptides from selenium-enriched oysters that strongly inhibit ACE, improve vascular function, and outperform captopril in vitro, highlighting their promise as natural antihypertensive ingredients.
Tony Edge explores 2026 trends in chromatography, highlighting the impact of AI and automation on the industry.
Velaris has acquired Markes International from Schauenburg International, strengthening its automated sample preparation portfolio, expanding its global presence, and enhancing support for laboratories across multiple end markets.
A recent study investigated the nutritional composition, bioactive compounds, and in vitro rumen fermentation characteristics of two tropical seaweeds, brown seaweed (Sargassum binderi) and green seaweed (Kappaphycus striatum), as potential functional feed additives for ruminant livestock profiled amino acids and fatty acids using HPLC and GC-FID, respectively.
Gas analyzers are evolving to meet modern demands, enhancing legacy systems with real-time insights and connectivity for improved operational efficiency and compliance.
To characterize the per- and polyfluoroalkyl substance (PFAS) content and migration potential of winter gloves and conduct a screening-level risk assessment of perfluorooctanoic acid (PFOA) and perfluorohexanoic acid (PFHxA) glove exposures in children aged 2-6 (considering both hand-to-mouth transfer and dermal absorption), experimental data were generated through total fluorine analysis, liquid chromatography–tandem mass spectrometry (LC–MS/MS), gas chromatography–tandem mass spectrometry (GC–MS/MS), and leachate testing of individual glove components across eight glove brands.
A review of some of the content highlights from LCGC International in 2025.
Research conducted by the Department of Food Science and Technology of Oregon State University and the Legacy Research Institute of Dow Neurobiology addressed this gap by developing a standardized aroma lexicon and associated sensory methodology, supported by GC-MS analysis of terpenes and terpenoids plus GC-PFPD analysis of volatile sulfur compounds. LCGC International spoke to Thomas H. Shellhammer of Oregon State University about this work.
In its 2025 industry survey, LCGC International looked beyond the numbers to uncover the challenges, priorities, and outlook shaping the chromatography community, and what lies ahead in 2026.
As a long-standing member of the chromatography community, I am continually awestruck by the rate of change we consistently experience. Through the collective efforts of an entire community, we realize a fast-paced evolution that serves the world. In this article, we will aim to make the rapidly expanding and dynamic field of biopharmaceuticals approachable by taking a high-level look into its most recent success: peptide-based therapeutics.
Aiming to determine the presence of heroin, fentanyl, amphetamine-type stimulants (ATS), xylazine, and other substances in Tijuana and Mexicali, Baja California, researchers randomly selected 300 drug residues from confiscated syringe plungers. After analyzing them with gas chromatography–mass spectrometry (GC–MS) and BTNX test strips for ATS and fentanyl and its analogs, the test strips showed a high positive predictive value of 81% when compared with GC–MS.
To capture an early view of what lies ahead in 2026, LCGC International convened a panel of leading voices from academia and industry to reflect on the trends they believe will most strongly influence the field in the coming year.
In this second installment of a multi-part series, we describe the principles of ion-pair reversed-phase high performance liquid chromatography, discuss strategies for method development, and provide practical tips for robust liquid chromatography analyses of oligonucleotide mixtures.
Research conducted at the Federal University of Pelotas (Brazil) investigated the formulation of oleogels based on Butia seed oil and their potential as a replacement for hydrogenated fats in cookies. Gas chromatography (GC) was used to determine the fatty acid profile and identify and quantify volatile organic compounds (VOCs).
Join us as we explore the innovations that defined 2025—and what they mean for the future of the field.
UHPLC-QTOF metabolomics and the Global Natural Products Social Molecular Networking (GNPS) platform revealed 185 secondary metabolites in Egyptian blue lily, which link flavonoid-rich flowers to antioxidant neuroprotective potential activities.
LCGC International presents a sampler of our 2025 interviews with key opinion leaders in the field of chromatography, exploring emerging trends, persistent analytical challenges, and the innovations poised to redefine separation science.
Emerging blood microsampling technologies offer a promising alternative by enabling minimally invasive, user-friendly collection, facilitating repeated sampling and broader population recruitment. A recent study conducted at Stockholm University critically reviewed commercially available microsamplers, their use in multiomics research, and experimentally evaluated their chemical backgrounds. LCGC International spoke to Solveig Thiele, lead author of the resulting paper, about this work.
Egyptian scorpions of the Androctonus genus produce neurotoxic venom that result in life-threatening stings. However, the composition and enzymatic activities of their venoms remain poorly understood. Researchers used electrophoresis to analyze the protein components of venom collected from three Androctonus species, with high-performance liquid chromatography (HPLC) and mass spectrometry (MS).
Researchers developed a liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for the simultaneous measurement of 11 types of estrogen from song sparrows using derivatization with 1,2-dimethylimidazole-5-sulfonyl-chloride (DMIS) to enhance sensitivity.
As a response to the growing interest in identifying novel, non-invasive biomarkers reflecting endogenous inflammatory processes in asthma, researchers evaluated the presence of volatile organic compounds (VOCs) in exhaled breath from patients with clinically controlled asthma to assess how tobacco exposure influences their expression. Breath samples were analyzed using gas chromatography-mass spectrometry (GC-MS).
Determining the pharmacokinetics of famciclovir in healthy cats after single or multiple oral and intravenous administrations involved the analysis of their blood samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for detecting the drug in their plasma.
Researchers optimized two-dimensional liquid chromatography (2D-LC) using a Design of Experiments-guided optimization approach to overcome breakthrough effects, enabling high-resolution oligonucleotide impurity profiling beyond conventional 1D-LC. LCGC International spoke to Megane Aebischer of the Institute of Pharmaceutical Sciences of Western Switzerland, lead author of the paper that resulted from this work.
