May 8th 2024
Yelena Sapozhnikova from the United States Department of Agriculture spoke to The Column about her innovative research investigating PFAS in plastic food storage bags using targeted and non-targeted liquid chromatography–tandem mass spectrometry.
New Procedures Enhance Quality Control for Large-Scale Plasma Proteomics Analyses
May 24th 2023A recent study has introduced comprehensive quality control procedures for large-scale plasma proteomics analyses. The research provides valuable insights into optimizing performance, enhancing reproducibility, and ensuring quantitative accuracy in proteomics investigations.
New Technique Reveals Hidden Structures of Lipid A with Multiple Glycosylation Sites
May 24th 2023A new tandem mass spectrometry technique has been developed for the rapid determination of complex lipid A structures, including novel variations from arctic bacterioplankton. This study enhances our understanding of bacterial adaptations and paves the way for the development of targeted therapies and antimicrobial agents.
Ink Source Prediction and Assessment Made Possible by Mass Spectrometry
May 22nd 2023Scientists have developed a new method for predicting and assessing the source of black inks using direct analysis in real-time mass spectrometry. By applying dimensionality reduction techniques and likelihood ratio analysis, the researchers achieved high accuracy in identifying ink sources, demonstrating the potential of this approach in forensic ink analysis.
New Ultrasensitive LC–MS/MS Method Allows for Accurate Melatonin Quantification in Human Saliva
May 8th 2023A new study reports the development a highly sensitive LC–MS/MS method to measure salivary melatonin levels. The method has a lower limit of the measuring interval of 0.8 pg/mL, making it the most sensitive method for quantifying melatonin in saliva.
Study Finds That Using Seven Points Across a Peak Is Sufficient for Accurate LC–MS/MS Quantitation
May 8th 2023A recent study has found that using only seven points across an LC–MS/MS peak can provide sufficient accuracy and precision for drug quantitation studies in drug discovery and development, challenging the "rule-of-thumb" of using at least 15 points.
New Study Identifies Potential for Anticancer Drugs in Solanum Nigrum Fruits
May 5th 2023A recent study analyzed the composition and metabolism of steroidal alkaloids in Solanum nigrum fruits of different maturities and identified steroidal glycoalkaloids and steroidal alkaloids, providing a foundation for further research on biosynthesis and discovery of new steroidal alkaloid anticancer drugs.
Computational Framework Developed to Evaluate Monoclonal Antibody Capture Chromatography Platforms
May 3rd 2023Researchers at Clemson University have developed a computational framework that integrates commercial software components to perform customizable technoeconomic feasibility analyses of monoclonal antibody capture chromatography platforms.
The LCGC Blog: Forensics Laboratories Underassess Uncertainty in Blood Alcohol Determinations
May 2nd 2023The level of uncertainty provided by most forensic laboratories for reported blood alcohol results has been woefully underassessed. Not only is this bad science, but someone’s civil liberties may be at stake.
New Mass Spectrometry Tool to Quantify Cell Heterogeneity and Subpopulations in Cancer
May 2nd 2023Researchers combine a single-probe single cell mass spectrometry technique with a bioinformatics software package to quantify cell subpopulations and prioritize metabolite biomarkers, providing a label-free approach to studying cell heterogeneity and improving understanding of cell metabolism in human diseases and response to therapy.
Wuhan University Researchers Develop New Method for Detecting Pyrethroid Pesticides in Tobacco
May 2nd 2023Researchers have developed a new method for detecting pyrethroid pesticide residues in tobacco using Schiff base networks (SNWs) coated stir bar sorptive extraction (SBSE) coupled with high performance liquid chromatography-ultraviolet detection (HPLC-UV), which exhibited high extraction efficiency and good mechanical stability even when reused more than 50 times.
New Method Developed to Map Cellulose Ether Monomer Composition
May 2nd 2023A new RPLC–MS method can map the substitution degree and composition of β-glucose monomers of cellulose ethers (CEs), providing detailed compositional distributions and constitutional isomer distributions, thereby identifying compositional variation between bio-stable and non-bio-stable CEs and unexpected methylations in EHEC samples.
Analysis of PFAS in Locally Acquired Food Containers
May 1st 2023The combination of an untargeted approach using ultrahigh pressure liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF) and a targeted approach using UHPLC–tandem mass spectrometry (MS/MS) are presented as an ideal method for detecting per- and polyfluroalkyl substances (PFAS) in fast-food packaging.
Ion Chromatography Helps Researchers Identify Forest Fire Emissions in Rainfall Samples
April 28th 2023Researchers have shown the effectiveness of ion chromatography (IC) in identifying markers of forest fire emissions in rainfall samples, providing valuable insights into the signature of forest fire emissions and aiding in the development of models to predict and control air pollution resulting from these events.
Advancements in High Spatial Resolution Mass Spectrometry Imaging for Spatial Metabolomics
April 28th 2023A review article describes spatial metabolomics using high spatial resolution mass spectrometry imaging (MSI), a promising technology that enables the visualization and analysis of metabolites at the cellular and subcellular levels.
ESI-MS: The Future of Single-Cell Proteomics
April 28th 2023Recent advancements in electrospray ionization mass spectrometry (ESI-MS) for single-cell proteomics are highlighted in a review article, including various separation techniques and MS instrumentation used to improve sample throughput and coverage.