Biological, Medical, and Clinical Analysis

University of Oslo scientists combined electromembrane extraction (EME) and flow injection-MS/MS (FI–MS/MS) to determine polar endogeneous metabolites in human plasma.

University of Innsbruck scientists recently used ultrahigh-performance supercritical fluid chromatography to facilitate the determination of anthraquinone derivatives in alder buckthorn.

New gene therapy modalities, such as CRISPR guide RNA (single guide ribonucleic acid [sgRNA]) and messenger RNA (mRNA), continue to make progress in both primate and first-in-human trials. As this progress builds, the industry remains accountable for characterizing these molecules to meet the requirements of regulatory authorities.

Throughout 2024, the editors of LCGC International attended chromatography conferences across the globe. Below, you’ll find a sampling and overview of our conference coverage from the year.

This article highlights a curated selection of the most popular GC-related content, with a focus on the diverse applications of the technique, as featured in LCGC.

In this column, we discuss the label-free and stable isotope labeling proteomics approaches that help in biomarker discovery. We also discuss the different enrichment techniques, such as stable isotope labeling by amino acid in cell culture (SILAC), isobaric tags for relative and absolute quantitation (iTRAQ), and tandem mass tags (TMT, that help in measuring low-abundance protein biomarkers.

Ronald Piervincenzi, chief executive officer of the United States Pharmacoepia, focused on how collaboration and component quality can improve worldwide pharmaceutical production standards during a lecture at the Eastern Analytical Symposium (EAS) last month.

Messina Institute of Technology scientists used gas chromatography–mass spectrometry (GC–MS) to profile illegal samples of Cannabis sativa L.

Known as “forever chemicals”, PFAS exposure has been linked indirectly and directly to a range of potential health issues. The objective of this study was the development of an optimized sample preparation and LC–MS/MS method for the analysis of PFAS in serum for biomonitoring applications.

Shanghai University of Sport scientists recently developed a doping control method based on gas chromatography combustion isotope ratio mass spectrometry (GC/C/IRMS).

Giorgia Purcaro from the University of Liège was interviewed at RAFA 2024 by LCGC International on the benefits of modern multidimensional GC methods to analyze mineral oil aromatic hydrocarbons (MOAH) and mineral oil saturated hydrocarbons (MOSH).

Here is some of the most popular content posted on LCGC International this week.

Elena Canellas and Paula Vera recently spoke with us about the dangers that come with using paper straws, and what potential substitutes could be.

Here is some of the most popular content posted on LCGC International this week.

LCGC International interviewed FeMS Empowerment Award winner Marta Relvas-Santos on her use of mass spectrometry to identify potential biomarkers and therapies for bladder cancer. She also shared insights on her work with FeMS and advice for fellow scientists.

The method of standard additions (MoSA) enables quantification of volatile impurities in condensed-phase samples, such as emulsions, for which matrix-matched calibration standards are required. The technique is, however, expensive because it requires multiple analyses of each sample.

Here is some of the most popular content posted on LCGC International this week.

Mithibai College of Arts scientists recently used liquid chromatography-tandem mass spectrometry (LC–MS/MS) for detecting nitrosamines in blood pressure medication.

Scientists recently developed new GC/LC-Q-TOF/MS-based method for determining pesticides in Angelica sinensis, a traditional Chinese medicine.

Messina Institute of Technology scientists used gas chromatography–mass spectrometry (GC–MS) was used to profile illegal samples of Cannabis sativa L.

Here is some of the most popular content posted on LCGC International this week.

The grant will be part of a new collaborative scientific initiative to address the need for standards that define the desired performance of lateral flow immunoassay test strips to detect illicit drugs in tablets and powders.

Nicholas Ingram of IQVIA Laboratories recently spoke with LCGC International about using high-resolution mass spectrometry (HRMS) to help monitor drug stability.

Scientists from Peking Union Medical College & Chinese Academy of Medical Sciences created a new method for separating palonosetron hydrochloride, which is frequently used to prevent acute or delated nausea and vomiting caused by chemotherapy.

Here is some of the most popular content posted on LCGC International this week.