June 10th 2024
This article describes the contents and associated calculations of CoAs for small-molecule drugs. It explains how these documents help to ensure drug quality in the supply chain.
The Reality of Lab-on-a-Chip Technology for the Mass Spectrometry Laboratory
October 1st 2009In this installment of "MS-The Practical Art," guest columnist Jack Henion presents an historical and practical overview of lab-on-a-chip (LOC) research and the commercial achievement associated with it so far.
Liquid-Liquid-Liquid Microextraction of Nerve Agents
June 1st 2009Researchers from Vertox Laboratory, Defence Research and Development Establishment (Gwalior, India) used a liquid-liquid-liquid microextraction technique followed by liquid chromatography?mass spectrometry (LC?MS) to examine alkyl alkylphosphonic acids, which are important environmental markers of nerve agents.
SPE of Lipophilic Marine Biotoxins
June 1st 2009A research group from NRL Marine Biotoxins, Federal Institute for Risk Assessment (Berlin, Germany) developed a solid-phase extraction (SPE) method for the enrichment and clean-up of lipophilic marine biotoxins from various species of bivalve molluscs and processed shellfish products.
Dispersive Liquid-Phase Microextraction of Aromatic Amines in Water
June 1st 2009Scientists from Henan Normal University (Xinxiang, China) and the University of Science and Technology Beijing (Beijing, China) developed an ultrasound-assisted ionic liquid dispersive liquid-phase microextraction procedure for determining four aromatic amines in water samples.
Analysis of Genotoxic Impurities
May 1st 2009Researchers from the Research Institute for Chromatography (Kortrijk, Belgium) and AstraZeneca R&D Charnwood (Loughborough, UK) used in-situ derivatization and liquid chromatography?mass spectrometry (LC?MS) to analyze arylamines and aminopyridines, which can be present as potentially genotoxic impurities in pharmaceutical preparations at trace levels.